Michigan vs Northwestern Prediction, Odds, Picks, Best Bets for Week 12 2025

On Saturday in college football, the Michigan Wolverines are up against the Northwestern Wildcats.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Michigan vs Northwestern Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Michigan: (-420) | Northwestern: (+330)
• Spread: Michigan: -10.5 (-105) | Northwestern: +10.5 (-115)
• Total: 41.5 -- Over: (-110) | Under: (-110)

Michigan vs Northwestern Betting Trends

• Michigan is 3-6-0 against the spread this season.
• As a 10.5-point or greater favorite, Michigan has one win ATS (1-4) this season.
• There have been four Michigan games (of nine) that went over the total this year.
• Against the spread, Northwestern is 6-3-0 this season.
• Northwestern has two wins ATS (2-1) as a 10.5-point underdog or greater this year.
• Northwestern has seen three of its nine games go over the point total.

Michigan vs Northwestern Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Wolverines win (79.9%)

Michigan vs Northwestern Point Spread

Michigan is favored by 10.5 points over Northwestern. Michigan is -105 to cover the spread, with Northwestern being -115.

Michigan vs Northwestern Over/Under

An over/under of 41.5 has been set for Michigan-Northwestern on Nov. 15, with the over being -110 and the under -110.

Michigan vs Northwestern Moneyline

Michigan is the favorite, -420 on the moneyline, while Northwestern is a +330 underdog.

Michigan vs. Northwestern Points Insights

Michigan vs. Northwestern Game Info

• Game day: Saturday, November 15, 2025
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: Chicago, Illinois
• Stadium: Wrigley Field

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Check out even more in-depth Michigan vs. Northwestern analysis on FanDuel Research.