Mets vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 12:12 p.m.

The MLB's Thursday slate includes the New York Mets facing the San Diego Padres.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Mets vs Padres Game Info

• New York Mets (78-74) vs. San Diego Padres (83-69)
• Date: Thursday, September 18, 2025
• Time: 1:10 p.m. ET
• Venue: Citi Field -- Queens, New York
• Coverage: MLB Network, SNY, and SDPA

Mets vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYM: (-142) | SD: (+120)
• Spread: NYM: -1.5 (+142) | SD: +1.5 (-172)
• Total: 9 -- Over: (-105) | Under: (-115)

Mets vs Padres Probable Starting Pitchers

Probable Pitchers: Jonah Tong (Mets) - 1-2, 8.49 ERA vs Randy Vasquez (Padres) - 5-6, 3.72 ERA

The Mets will call on Jonah Tong (1-2) against the Padres and Randy Vasquez (5-6). When Tong starts, his team is 1-2-0 against the spread this season. Tong's team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 1-2. The Padres have a 15-8-0 ATS record in Vasquez's 23 starts with a set spread. The Padres have been the moneyline underdog in 15 of Vasquez's starts this season, and they went 8-7 in those games.

Mets vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.9%)

Mets vs Padres Moneyline

• Looking at the moneyline for Padres-Mets, San Diego is the underdog at +120, and New York is -142 playing at home.

Mets vs Padres Spread

• The Mets are favored by 1.5 runs at home against the Padres. The Mets are +142 to cover the spread, while the Padres are -172.

Mets vs Padres Over/Under

• Mets versus Padres, on Sept. 18, has an over/under of 9, with the over being -105 and the under -115.

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Mets vs Padres Betting Trends

• The Mets have won in 59, or 57.3%, of the 103 contests they have been named as odds-on favorites in this year.
• This season New York has come away with a win 33 times in 64 chances when named as a favorite of at least -142 on the moneyline.
• The Mets and their opponents have hit the over in 68 of their 145 games with a total set by oddsmakers this season.
• The Mets are 67-78-0 against the spread in their 145 games with a line set by sportsbooks this season.
• The Padres have gone 31-33 in games they were the underdog on the moneyline (winning 48.4% of those games).
• San Diego has gone 12-16 when playing as a moneyline underdog with odds of +120 or longer (42.9%).
• The Padres have combined with opponents to go over the total 66 times this season for a 66-81-3 record against the over/under.
• The Padres have covered 54% of their games this season, going 81-69-0 against the spread.

Mets Player Leaders

• Juan Soto leads New York with 141 hits and an OBP of .394 this season. He has a .261 batting average and a slugging percentage of .526.
• He is 62nd in batting average, second in on-base percentage, and 11th in slugging among all qualified hitters in baseball.
• Soto hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .190 with two home runs, a walk and four RBIs.
• Francisco Lindor has an OPS of .793, fueled by an OBP of .340 and a team-best slugging percentage of .453 this season. He's batting .264.
• Among qualified hitters, he is 51st in batting average, 51st in on-base percentage and 58th in slugging percentage.
• Lindor has picked up at least one hit in six straight games. During his last 10 outings he is batting .184 with a double, a home run, five walks and an RBI.
• Pete Alonso has collected 158 base hits, an OBP of .344 and a slugging percentage of .520 this season.
• Alonso takes a four-game hitting streak into this game. In his last five games he is hitting .350 with three home runs, a walk and six RBIs.
• Brandon Nimmo has 23 home runs, 83 RBI and a batting average of .261 this season.

Padres Player Leaders

• Fernando Tatis Jr. has 27 doubles, two triples, 22 home runs and 88 walks while batting .265. He's slugging .436 with an on-base percentage of .368.
• Including all the qualified hitters in MLB, he ranks 50th in batting average, 13th in on-base percentage and 71st in slugging percentage.
• Manny Machado has 163 hits to pace his team. He has a batting average of .279 while slugging .469 with an on-base percentage of .340.
• His batting average ranks 26th among all qualified players, his on-base percentage ranks 51st, and he is 42nd in slugging.
• Luis Arraez has a .386 slugging percentage, which leads the Padres.
• Ramon Laureano has 25 doubles, two triples, 24 home runs and 34 walks while batting .288.

Mets vs Padres Head to Head

• 9/17/2025: 7-4 SD (Favorite: Mets, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/16/2025: 8-3 NYM (Favorite: Mets, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 7/30/2025: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/29/2025: 7-1 SD (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/28/2025: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/25/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/24/2024: 7-1 NYM (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/23/2024: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/22/2024: 8-3 NYM (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/16/2024: 11-6 NYM (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)

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