Louisville vs Virginia Tech Prediction, Odds, Picks, Best Bets for Week 10 2025

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The Louisville Cardinals versus the Virginia Tech Hokies is on the college football schedule for Saturday.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Louisville vs Virginia Tech Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Louisville: (-370) | Virginia Tech: (+295)
Spread: Louisville: -10.5 (-105) | Virginia Tech: +10.5 (-115)
Total: 52.5 -- Over: (-110) | Under: (-110)

Louisville has two wins against the spread this year.
Louisville has yet to win ATS (0-4) when playing as at least 10.5-point favorites this season.
Out of seven Louisville games so far this season, four have gone over the total.
Virginia Tech has posted two wins against the spread this year.
Virginia Tech has no wins ATS (0-1) as a 10.5-point underdog or more this year.
This year, five of Virginia Tech's eight games have gone over the point total.

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (81%)

Louisville is favored by 10.5 points over Virginia Tech. Louisville is -105 to cover the spread, with Virginia Tech being -115.

A total of 52.5 points has been set for the Louisville-Virginia Tech game on Nov. 1, with the over available at -110 and the under at -110.

The moneyline numbers for Louisville vs. Virginia Tech reveal Louisville as the favorite (-370) and Virginia Tech as the underdog (+295).

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Louisville	34.6	50	21.4	31	54.6	7
Virginia Tech	25.4	85	29.9	105	51.1	8

Check out even more in-depth Louisville vs. Virginia Tech analysis on FanDuel Research.

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