Louisville vs Ohio College Basketball Prediction, Odds, Picks, Best Bets for Nov. 15

The Louisville Cardinals (3-0) will try to build on a three-game winning streak when they host the Ohio Bobcats (1-2) on November 15, 2025 at KFC Yum! Center.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Ohio Game Info and Odds

• Game day: Saturday, November 15, 2025
• Game time: 12 p.m. ET
• TV channel: The CW Network
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

Louisville vs. Ohio Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (95.8%)

Before you bet on Saturday's Louisville-Ohio spread (Louisville -31.5) or over/under (175.5 points), read the betting insights and trends below.

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Louisville vs. Ohio: ATS Betting Stats and Trends

• Louisville covered 20 times in 35 chances against the spread last season.
• Ohio covered 12 times in 31 games with a spread last season.
• The Cardinals did a better job covering the spread when playing on the road (9-2-0) than they did in home games (8-9-0) last season.
• The Bobcats' winning percentage against the spread at home last season was .571 (8-6-0). On the road, it was .231 (3-10-0).

Louisville vs. Ohio Head-to-Head Comparison

• Louisville put up 78.5 points per game and gave up 69.5 last year, ranking them 65th in college basketball on offense and 89th defensively.
• With 34.6 rebounds per game and 30.2 rebounds allowed, Louisville was 47th and 114th in college basketball, respectively, last year.
• With 13.9 assists per game last season, Louisville was 148th in the nation.
• Louisville committed 10.9 turnovers per game last season and forced 12.2 per game, ranking 150th and 93rd, respectively, in the country.
• Ohio scored 79.8 points per game (43rd-ranked in college basketball) last season, while surrendering 76.5 points per contest (304th-ranked).
• With 29 rebounds per game, Ohio was 327th in the nation. It gave up 32.3 rebounds per contest, which ranked 257th in college basketball.
• Ohio put up 14.1 dimes per game, which ranked them 135th in the nation.
• Ohio averaged 10.6 turnovers per game (129th-ranked in college basketball) this year, while forcing 12.1 turnovers per contest (100th-ranked).

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