Louisville vs Ohio College Basketball Prediction, Odds, Picks, Best Bets for Nov. 15

The Louisville Cardinals (3-0) will look to continue a three-game win streak when they host the Ohio Bobcats (1-2) on November 15, 2025 at KFC Yum! Center.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Ohio Game Info and Odds

• Game day: Saturday, November 15, 2025
• Game time: 12 p.m. ET
• TV channel: The CW Network
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

Louisville vs. Ohio Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (95.8%)

Louisville is a 30.5-point favorite over Ohio on Saturday and the over/under has been set at 175.5 points. Here's some betting trends and insights if you are planning on making a wager on the outing.

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Louisville vs. Ohio: ATS Betting Stats and Trends

• Louisville covered 20 times in 35 chances against the spread last season.
• Ohio put together a 12-19-0 ATS record last year.
• The Cardinals owned a worse record against the spread when playing at home (8-9-0) than they did in away games (9-2-0) last season.
• In 2024-25 against the spread, the Bobcats had a better winning percentage at home (.571, 8-6-0 record) than on the road (.231, 3-10-0).

Louisville vs. Ohio Head-to-Head Comparison

• At 78.5 points scored per game and 69.5 points allowed last season, Louisville was 65th in the country offensively and 89th on defense.
• At 34.6 rebounds per game and 30.2 rebounds conceded, Louisville was 47th and 114th in college basketball, respectively, last season.
• Last season Louisville was ranked 148th in college basketball in assists with 13.9 per game.
• In terms of turnovers, Louisville was 150th in the nation in committing them (10.9 per game) last year. It was 93rd in forcing them (12.2 per game).
• Ohio was 43rd in college basketball last season with 79.8 points per game. At the other end, it ranked 304th with 76.5 points allowed per game.
• Last season Ohio pulled down 29 rebounds per game (327th-ranked in college basketball) and allowed 32.3 rebounds per contest (257th-ranked).
• Ohio averaged 14.1 assists per game, which ranked them 135th in college basketball.
• With 10.6 turnovers per game, Ohio ranked 129th in the nation. It forced 12.1 turnovers per contest, which ranked 100th in college basketball.

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