Louisiana Tech vs Southern Miss Prediction, Odds, Picks, Best Bets for Week 4 2025

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In college football action on Saturday, the Louisiana Tech Bulldogs take on the Southern Miss Golden Eagles.

We've got you covered, in terms of the vital info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Louisiana Tech vs Southern Miss Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Louisiana Tech: (-154) | Southern Miss: (+128)
Spread: Louisiana Tech: -3.5 (-102) | Southern Miss: +3.5 (-120)
Total: 49.5 -- Over: (-110) | Under: (-110)

Louisiana Tech is unbeaten against the spread this season.
Louisiana Tech is unbeaten ATS (2-0) as a 3.5-point favorite or greater this season.
One of Louisiana Tech's three games this season has gone over the point total.
Southern Miss has posted two wins against the spread this season.
As a 3.5-point underdog or greater, Southern Miss has one win ATS (1-1) this season.
Two Southern Miss games (of three) have hit the over this season.

All college football win probability predictions and picks are according to numberFire.
Prediction: Bulldogs win (74%)

Southern Miss is listed as an underdog by 3.5 points (-120 odds), and Louisiana Tech, the favorite, is -102 to cover.

The over/under for Louisiana Tech-Southern Miss on Sept. 20 is 49.5. The over is -110, and the under is -110.

Southern Miss is the underdog, +128 on the moneyline, while Louisiana Tech is a -154 favorite.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Louisiana Tech	26.7	77	12.3	27	47.2	3
Southern Miss	31.0	61	25.3	94	56.5	3

Check out even more in-depth Louisiana Tech vs. Southern Miss analysis on FanDuel Research.

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