Louisiana Tech vs Southern Miss Prediction, Odds, Picks, Best Bets for Week 4 2025

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College football's Saturday schedule includes the Louisiana Tech Bulldogs facing the Southern Miss Golden Eagles.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Louisiana Tech vs Southern Miss Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Louisiana Tech: (-162) | Southern Miss: (+134)
Spread: Louisiana Tech: -3.5 (-105) | Southern Miss: +3.5 (-115)
Total: 50.5 -- Over: (-114) | Under: (-106)

Louisiana Tech hasn't lost a game against the spread this season.
Louisiana Tech is unbeaten ATS (2-0) as a 3.5-point favorite or greater this season.
Louisiana Tech has had one game (of three) go over the total this year.
Southern Miss has won twice against the spread this season.
Southern Miss has one win ATS (1-1) as a 3.5-point underdog or greater this season.
Southern Miss has played two games (out of three) which finished over the total this season.

All college football win probability predictions and picks are according to numberFire.
Prediction: Bulldogs win (74.2%)

Louisiana Tech is a 3.5-point favorite against Southern Miss. Louisiana Tech is -105 to cover the spread, and Southern Miss is -115.

The over/under for Louisiana Tech-Southern Miss on Sept. 20 is 50.5. The over is -114, and the under is -106.

Louisiana Tech is a -162 favorite on the moneyline, while Southern Miss is a +134 underdog.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Louisiana Tech	26.7	79	12.3	26	47.2	3
Southern Miss	31.0	61	25.3	91	56.5	3

Check out even more in-depth Louisiana Tech vs. Southern Miss analysis on FanDuel Research.

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