Lakers vs. Spurs Prediction, Odds, Picks, Best Bets for Nov. 5

Lakers vs. Spurs Game Info

• Date: Wednesday, November 5, 2025
• Time: 10 p.m. ET
• Venue: Crypto.com Arena -- Los Angeles, California
• Coverage: ESPN, SportsNet LA, and FDSSW

The Los Angeles Lakers (6-2) are favored (-3) to build on a four-game win streak when they host the San Antonio Spurs (5-1) at 10 p.m. ET on Wednesday, November 5, 2025 at Crypto.com Arena. The contest airs on ESPN, SportsNet LA, and FDSSW. The matchup's over/under is 230.5.

Lakers vs. Spurs Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Lakers vs. Spurs Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Lakers win (72.7%)

Lakers vs. Spurs Betting Trends

• The Lakers have registered a 6-2-0 record against the spread this season.
• The Spurs have covered the spread twice this season.
• This season, Lakers games have hit the over seven times out of six chances.
• Spurs games this year have gone over the total in two of six opportunities (33.3%).
• Los Angeles has done a better job covering the spread on the road (4-0-0) than it has in home games (2-2-0).
• In home games, the Lakers go over the over/under 100% of the time (four of four games). They've hit the over in 75% of away games (three of four contests).

Lakers Leaders

• Austin Reaves' numbers on the season are 31.1 points, 5.1 rebounds and 9.3 assists per contest, shooting 48.9% from the field and 34.4% from beyond the arc, with an average of 3 made treys.
• Luka Doncic is averaging 41.3 points, 8.3 assists and 11.5 rebounds.
• Jake Laravia is averaging 12.6 points, 3 assists and 5.1 boards.
• Deandre Ayton is averaging 16.9 points, 8.1 boards and 1.3 assists.
• Rui Hachimura averages 16.9 points, 4.1 rebounds and 1.8 assists, shooting 59.3% from the floor and 45.5% from beyond the arc, with 1.9 made 3-pointers per game.

Spurs Leaders

• Per game, Victor Wembanyama gives the Spurs 26.7 points, 13.7 rebounds and 3.2 assists. He also averages 1.3 steals and 4.7 blocks (first in NBA).
• The Spurs are getting 20 points, 6.2 rebounds and 5.3 assists per game from Stephon Castle.
• Devin Vassell's numbers on the season are 14.7 points, 4.3 rebounds and 2.3 assists per contest. He is draining 41.3% of his shots from the floor and 35.4% from beyond the arc, with an average of 2.8 triples.
• Keldon Johnson averages 13 points, 5.3 boards and 1.2 assists. He is draining 61.2% of his shots from the floor (10th in NBA) and 46.7% from beyond the arc, with 1.2 treys per contest.
• Julian Champagnie averages 7.5 points, 6.2 rebounds and 1.8 assists. He is making 42.4% of his shots from the field and 30.4% from 3-point range, with 1.2 treys per game.

For more NBA betting insights, check out FanDuel Research's NBA home page.

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