Lakers vs. Spurs Prediction, Odds, Picks, Best Bets for Nov. 5

Lakers vs. Spurs Game Info

• Date: Wednesday, November 5, 2025
• Time: 10 p.m. ET
• Venue: Crypto.com Arena -- Los Angeles, California
• Coverage: ESPN, SportsNet LA, and FDSSW

The Los Angeles Lakers (6-2) are 1.5-point underdogs as they look to build on a four-game winning streak when they host the San Antonio Spurs (5-1) on Wednesday, November 5, 2025 at Crypto.com Arena. The contest airs at 10 p.m. ET on ESPN, SportsNet LA, and FDSSW. The matchup has an over/under set at 227.5 points.

Lakers vs. Spurs Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Lakers vs. Spurs Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction:

Lakers vs. Spurs Betting Trends

• The Spurs are 2-2-2 against the spread this season.
• The Lakers have six wins against the spread in eight games this season.
• Games involving the Spurs have hit the over twice out of eight chances this season.
• Lakers games this season have hit the over on seven of eight set point totals (87.5%).
• This season, Los Angeles is 2-2-0 at home against the spread (.500 winning percentage). Away, it is 4-0-0 ATS (1.000).
• Looking at the over/under, Lakers games have finished over four of four times at home (100%), and three of four away (75%).

Spurs Leaders

• Victor Wembanyama is averaging 26.7 points, 13.7 boards and 3.2 assists. Defensively, he averages 1.3 steals and 4.7 blocked shots (first in NBA).
• Stephon Castle averages 20 points, 6.2 boards and 5.3 assists, shooting 55.4% from the floor and 34.6% from downtown, with 1.5 made 3-pointers per contest.
• Devin Vassell averages 14.7 points, 4.3 boards and 2.3 assists.
• Keldon Johnson is averaging 13 points, 5.3 boards and 1.2 assists.
• Julian Champagnie is averaging 7.5 points, 6.2 rebounds and 1.8 assists.

Lakers Leaders

• Luka Doncic averages 41.3 points, 11.5 rebounds and 8.3 assists. He is also draining 54.5% of his shots from the field and 29.2% from 3-point range, with 3.5 triples per contest.
• Jake Laravia averages 12.6 points, 5.1 boards and 3 assists. He is also sinking 58.5% of his shots from the field and 44.4% from beyond the arc, with 1.5 treys per game.
• Deandre Ayton averages 16.9 points, 8.1 rebounds and 1.3 assists. He is sinking 65.1% of his shots from the field (fourth in NBA).
• The Lakers are getting 16.9 points, 4.1 rebounds and 1.8 assists per game from Rui Hachimura.
• Jarred Vanderbilt averages 4.8 points, 5.9 rebounds and 1.5 assists. He is making 43.3% of his shots from the field.

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