Knicks vs. 76ers Eastern Semifinals Prediction, Odds, Picks, Best Bets for May 6

Knicks vs. 76ers Game Info

• Date: Wednesday, May 6, 2026
• Time: 7 p.m. ET
• Venue: Madison Square Garden -- New York City, New York
• Coverage: ESPN

The New York Knicks are 6.5-point favorites heading into Game 2 of the second round of the NBA Playoffs against the Philadelphia 76ers at Madison Square Garden on Wednesday, beginning at 7 p.m. ET on ESPN. The Knicks hold a 1-0 lead in the series. The matchup has an over/under set at 215.5 points.

Knicks vs. 76ers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Knicks vs. 76ers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Knicks win (75.2%)

Knicks vs. 76ers Betting Trends

• The Knicks are 42-39-1 against the spread this season.
• In the 76ers' 82 games this season, they have 40 wins against the spread.
• Knicks games have finished with a final combined score above the over/under 37 times this season.
• 76ers games this year have eclipsed the over/under 41 times in 82 opportunities (50%).
• New York has done a better job covering the spread in home games (27-13-0) than it has in road tilts (15-26-1).
• At home, the Knicks exceed the over/under 47.5% of the time (19 of 40 games). They've hit the over in 42.9% of games on the road (18 of 42 contests).
• Against the spread, Philadelphia has had better results on the road (22-18-1) than at home (18-22-1).
• Looking at the over/under, 76ers games have finished over less frequently at home (20 of 41, 48.8%) than on the road (21 of 41, 51.2%).

Knicks Leaders

• Jalen Brunson is averaging 26 points, 3.3 boards and 6.8 assists. At the other end, he averages 0.8 steals and 0.1 blocked shots.
• Karl-Anthony Towns is averaging 20.1 points, 3 assists and 11.9 rebounds.
• Mikal Bridges' numbers on the season are 14.4 points, 3.8 boards and 3.7 assists per contest, shooting 49% from the floor and 37.1% from downtown, with an average of 1.9 made treys.
• OG Anunoby is averaging 16.7 points, 5.2 rebounds and 2.2 assists.
• Josh Hart averages 12 points, 7.4 rebounds and 4.8 assists, shooting 50.8% from the field and 41.3% from downtown, with 1.5 made 3-pointers per contest.

76ers Leaders

• Tyrese Maxey's numbers on the season are 28.3 points, 4.1 boards and 6.6 assists per game. He is also draining 46.2% of his shots from the field and 36.7% from 3-point range, with an average of 3.1 triples (ninth in NBA).
• The 76ers are getting 16 points, 5.6 rebounds and 4.2 assists per game from VJ Edgecombe.
• The 76ers receive 13.4 points per game from Quentin Grimes, plus 3.6 boards and 3.3 assists.
• The 76ers are getting 26.9 points, 7.7 boards and 3.9 assists per game from Joel Embiid.
• Andre Drummond averages 6.4 points, 8.4 rebounds and 1.3 assists. He is draining 47.2% of his shots from the floor.

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