Iowa State vs Mississippi State College Basketball Prediction, Odds, Picks, Best Bets for Nov. 10

The Mississippi State Bulldogs (1-0) battle the Iowa State Cyclones (2-0) at Sanford Pentagon on November 10, 2025.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Mississippi State Game Info and Odds

• Game day: Monday, November 10, 2025
• Game time: 8 p.m. ET
• TV channel: ESPNU
• Location: Sioux Falls, South Dakota
• Arena: Sanford Pentagon

Iowa State vs. Mississippi State Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (68.1%)

Iowa State is a 5.5-point favorite against Mississippi State on Monday and the over/under has been set at 150.5 points. Keep reading for a few betting trends and insights before you decide to wager on the outing.

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Iowa State vs. Mississippi State: ATS Betting Stats and Trends

• Iowa State went 20-15-0 ATS last season.
• Mississippi State covered 15 times in 34 games with a spread last season.
• Iowa State covered the spread when it was a 5.5-point favorite or more 58.6% of the time last year. That's more often than Mississippi State covered as an underdog by 5.5 or more (never covered last season).
• The Cyclones did a better job covering the spread when playing on the road (7-4-0) than they did in home games (9-8-0) last year.
• Last season, the Bulldogs were 6-9-0 at home against the spread (.400 winning percentage). Away, they were 6-5-0 ATS (.545).

Iowa State vs. Mississippi State: Moneyline Betting Stats

• Iowa State won 19 of the 25 games it was listed as the moneyline favorite last season (76%).
• The Cyclones went 14-4 last year (winning 77.8% of their games) when playing as a moneyline favorite of -260 or shorter.
• Last season, Mississippi State was the underdog six times and won two of those games.
• Last season, the Bulldogs were at least a +210 underdog on the moneyline three times, losing each of those contests.
• Iowa State has a 72.2% chance to win this matchup based on the moneyline's implied probability.

Iowa State vs. Mississippi State Head-to-Head Comparison

• At 80.3 points scored per game and 68.3 points allowed last year, Iowa State was 34th in college basketball on offense and 61st defensively.
• Iowa State grabbed 32.7 rebounds per game and gave up 28.3 boards last year, ranking 142nd and 31st, respectively, in college basketball.
• Last season Iowa State was ranked 77th in college basketball in assists with 15.0 per game.
• Iowa State was 232nd in college basketball in turnovers per game (11.6) and 13th-best in turnovers forced (14.4) last season.
• On offense, Mississippi State put up 79.5 points per game (47th-ranked in college basketball) last year. It surrendered 74.2 points per contest at the other end (245th-ranked).
• Mississippi State was 28th in the nation with 35.2 boards per game. Meanwhile, it ranked 283rd with 32.8 rebounds allowed per game.
• Last year Mississippi State ranked 69th in college basketball in assists, dishing out 15.2 per game.
• Mississippi State committed 10.3 turnovers per game (98th-ranked in college basketball). It forced 12.6 turnovers per contest (67th-ranked).

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