Iowa State vs Arkansas State Prediction, Odds, Picks, Best Bets for Week 3 2025

On Saturday in college football, the Iowa State Cyclones are playing the Arkansas State Red Wolves.

We've got you covered, in terms of the most important info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Iowa State vs Arkansas State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-2326) | Arkansas State: (+1060)
• Spread: Iowa State: -21.5 (-110) | Arkansas State: +21.5 (-110)
• Total: 56.5 -- Over: (-105) | Under: (-115)

Iowa State vs Arkansas State Betting Trends

• Iowa State has two wins against the spread this year.
• One of Iowa State's three games this season has gone over the point total.
• Arkansas State has but one win versus the spread this season.
• Arkansas State is winless ATS (0-1) when playing as at least 21.5-point underdogs this season.
• A pair of Arkansas State two games in 2025 have hit the over.

Iowa State vs Arkansas State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (92%)

Iowa State vs Arkansas State Point Spread

Iowa State is favored by 21.5 points against Arkansas State. Iowa State is -110 to cover the spread, while Arkansas State is -110.

Iowa State vs Arkansas State Over/Under

The over/under for the Iowa State versus Arkansas State matchup on Sept. 13 has been set at 56.5, with -105 odds on the over and -115 odds on the under.

Iowa State vs Arkansas State Moneyline

Arkansas State is the underdog, +1060 on the moneyline, while Iowa State is a -2326 favorite.

Iowa State vs. Arkansas State Points Insights

Iowa State vs. Arkansas State Game Info

• Game day: Saturday, September 13, 2025
• Game time: 4 p.m. ET
• TV channel: ESPN2
• Location: Jonesboro, Arkansas
• Stadium: Centennial Bank Stadium

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Check out even more in-depth Iowa State vs. Arkansas State analysis on FanDuel Research.