Iowa State vs Arizona Prediction, Odds, Picks, Best Bets for Week 5 2025

Saturday's slate in college football includes a matchup between the Iowa State Cyclones and the Arizona Wildcats.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Iowa State vs Arizona Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-230) | Arizona: (+188)
• Spread: Iowa State: -6.5 (-105) | Arizona: +6.5 (-115)
• Total: 48.5 -- Over: (-110) | Under: (-110)

Iowa State vs Arizona Betting Trends

• Iowa State has two wins against the spread this year.
• Iowa State has won once ATS (1-1) as a 6.5-point or higher favorite this season.
• One of Iowa State's four games this season has hit the over.
• Arizona has posted two wins against the spread this year.
• None of Arizona's two games has hit the over in 2025.

Iowa State vs Arizona Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (79.9%)

Iowa State vs Arizona Point Spread

Arizona is the underdog by 6.5 points against Iowa State. Arizona is -105 to cover the spread, and Iowa State is -115.

Iowa State vs Arizona Over/Under

Iowa State versus Arizona on Sept. 27 has an over/under of 48.5 points, with the over -110 and the under -110.

Iowa State vs Arizona Moneyline

Arizona is the underdog, +188 on the moneyline, while Iowa State is a -230 favorite.

Iowa State vs. Arizona Points Insights

Iowa State vs. Arizona Game Info

• Game day: Saturday, September 27, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Ames, Iowa
• Stadium: Jack Trice Stadium

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Check out even more in-depth Iowa State vs. Arizona analysis on FanDuel Research.