Iowa State vs Arizona Prediction, Odds, Picks, Best Bets for Week 5 2025

The Saturday schedule in college football includes a matchup between the Iowa State Cyclones and the Arizona Wildcats.

We've got you covered, in terms of the most important info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Iowa State vs Arizona Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-200) | Arizona: (+164)
• Spread: Iowa State: -5.5 (-110) | Arizona: +5.5 (-110)
• Total: 48.5 -- Over: (-105) | Under: (-115)

Iowa State vs Arizona Betting Trends

• Iowa State has posted two wins against the spread this season.
• Iowa State has won once ATS (1-1) as a 5.5-point or higher favorite this season.
• Iowa State has had one game (of four) go over the total this year.
• Arizona has won twice against the spread this year.
• None of Arizona's two games has hit the over in 2025.

Iowa State vs Arizona Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (78.6%)

Iowa State vs Arizona Point Spread

Iowa State is favored by 5.5 points versus Arizona. Iowa State is -110 to cover the spread, while Arizona is -110.

Iowa State vs Arizona Over/Under

The over/under for the Iowa State versus Arizona matchup on Sept. 27 has been set at 48.5, with -105 odds on the over and -115 odds on the under.

Iowa State vs Arizona Moneyline

Looking at the moneyline for Arizona-Iowa State, Arizona is the underdog at +164, and Iowa State is -200.

Iowa State vs. Arizona Points Insights

Iowa State vs. Arizona Game Info

• Game day: Saturday, September 27, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Ames, Iowa
• Stadium: Jack Trice Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Iowa State vs. Arizona analysis on FanDuel Research.