Indiana vs Illinois Prediction, Odds, Picks, Best Bets for Week 4 2025

On Saturday in college football, the Indiana Hoosiers are playing the Illinois Fighting Illini.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding today's NCAA football betting odds.

Indiana vs Illinois Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Indiana: (-245) | Illinois: (+198)
• Spread: Indiana: -6.5 (-115) | Illinois: +6.5 (-105)
• Total: 52.5 -- Over: (-110) | Under: (-110)

Indiana vs Illinois Betting Trends

• Indiana has two wins against the spread this season.
• Indiana has won twice ATS (2-1) as a 6.5-point or bigger favorite this season.
• Two of Indiana's three games have gone over the point total.
• Illinois' record against the spread in 2025 is 3-0-0.
• One of Illinois' three games has hit the over.

Indiana vs Illinois Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hoosiers win (81.6%)

Indiana vs Illinois Point Spread

Illinois is a 6.5-point underdog against Indiana. Illinois is -105 to cover the spread, and Indiana is -115.

Indiana vs Illinois Over/Under

The Indiana-Illinois matchup on Sept. 20 has been given an over/under of 52.5 points. The over is -110 and the under is -110.

Indiana vs Illinois Moneyline

The Indiana vs Illinois moneyline has Indiana as a -245 favorite, while Illinois is a +198 underdog.

Indiana vs. Illinois Points Insights

Indiana vs. Illinois Game Info

• Game day: Saturday, September 20, 2025
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: Bloomington, Indiana
• Stadium: Memorial Stadium (Bloomington, IN)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Indiana vs. Illinois analysis on FanDuel Research.