Illinois vs Duke Prediction, Odds, Picks, Best Bets for Week 2 2025

The Saturday schedule in college football includes a matchup between the Illinois Fighting Illini and the Duke Blue Devils.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Illinois vs Duke Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Illinois: (-138) | Duke: (+115)
• Spread: Illinois: -2.5 (-115) | Duke: +2.5 (-105)
• Total: 49.5 -- Over: (-110) | Under: (-110)

Illinois vs Duke Betting Trends

• Illinois is unbeaten against the spread this season.
• Illinois has covered every time (1-0) as a 2.5-point favorite or greater this year.
• Duke is winless against the spread this year.
• Duke has had one game (of one) hit the over this year.

Illinois vs Duke Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Illini win (60.5%)

Illinois vs Duke Point Spread

Duke is a 2.5-point underdog against Illinois. Duke is -105 to cover the spread, and Illinois is -115.

Illinois vs Duke Over/Under

The Illinois-Duke matchup on Sept. 6 has been given an over/under of 49.5 points. The over is -110 and the under is -110.

Illinois vs Duke Moneyline

Looking at the moneyline for Illinois-Duke, Illinois is the favorite at -138, and Duke is +115.

Illinois vs. Duke Points Insights

• The Fighting Illini had an average implied point total of 29.8 last season, which is 3.8 points higher than their implied total in Saturday's game (26).
• The 29.3-point average implied total last season for the Blue Devils is 5.3 more points than the team's 24-point implied total in this matchup.

Illinois vs. Duke Game Info

• Game day: Saturday, September 6, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Wilmington, North Carolina
• Stadium: Brooks Field at Wallace Wade Stadium

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Check out even more in-depth Illinois vs. Duke analysis on FanDuel Research.