Houston vs Colorado Prediction, Odds, Picks, Best Bets for Week 3 2025

NCAA football action on Friday includes the Houston Cougars facing the Colorado Buffaloes.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Houston vs Colorado Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Houston: (-215) | Colorado: (+176)
• Spread: Houston: -4.5 (-115) | Colorado: +4.5 (-105)
• Total: 44.5 -- Over: (-115) | Under: (-105)

Houston vs Colorado Betting Trends

• Houston hasn't lost a game against the spread this season.
• Houston is unbeaten ATS (2-0) as a 4.5-point favorite or greater this season.
• Houston has had one game (of two) go over the total this season.
• Colorado has posted one win against the spread this season.
• Not one of Colorado's two games has gone over the point total in 2025.

Houston vs Colorado Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cougars win (50.7%)

Houston vs Colorado Point Spread

Colorado is the underdog by 4.5 points against Houston. Colorado is -115 to cover the spread, and Houston is -105.

Houston vs Colorado Over/Under

The Houston-Colorado game on Sept. 12 has been given an over/under of 44.5 points. The over is -115 and the under is -105.

Houston vs Colorado Moneyline

Colorado is the underdog, +176 on the moneyline, while Houston is a -215 favorite.

Houston vs. Colorado Points Insights

Houston vs. Colorado Game Info

• Game day: Friday, September 12, 2025
• Game time: 7:30 p.m. ET
• TV channel: ESPN
• Location: Houston, Texas
• Stadium: TDECU Stadium

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Check out even more in-depth Houston vs. Colorado analysis on FanDuel Research.