Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 13

Odds updated as of 5:11 p.m.

MLB action on Saturday includes the Cleveland Guardians taking on the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Guardians vs White Sox Game Info

• Cleveland Guardians (76-71) vs. Chicago White Sox (57-91)
• Date: Saturday, September 13, 2025
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and CHSN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-168) | CHW: (+142)
• Spread: CLE: -1.5 (+126) | CHW: +1.5 (-152)
• Total: 7.5 -- Over: (-122) | Under: (-100)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 2-0, 1.93 ERA vs Davis Martin (White Sox) - 6-9, 4.03 ERA

The Guardians will call on Parker Messick (2-0) versus the White Sox and Davis Martin (6-9). Messick and his team have a record of 2-2-0 against the spread when he starts. Messick's team won his only start as a favorite this season. The White Sox have an 11-10-0 record against the spread in Martin's starts. The White Sox have been the underdog on the moneyline in 21 of Martin's starts this season, and they went 8-13 in those games.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (57.8%)

Guardians vs White Sox Moneyline

• Cleveland is a -168 favorite on the moneyline, while Chicago is a +142 underdog on the road.

Guardians vs White Sox Spread

• The White Sox are +1.5 on the spread (-152 to cover), and Cleveland is +126 to cover the runline.

Guardians vs White Sox Over/Under

• An over/under of 7.5 has been set for Guardians-White Sox on Sept. 13, with the over being -122 and the under -100.

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Guardians vs White Sox Betting Trends

• The Guardians have been chosen as favorites in 60 games this year and have walked away with the win 38 times (63.3%) in those games.
• This season Cleveland has been victorious seven times in eight chances when named as a favorite of at least -168 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 63 of their 144 opportunities.
• The Guardians are 77-67-0 against the spread in their 144 games that had a posted line this season.
• The White Sox have been the underdog on the moneyline 140 total times this season. They've finished 53-87 in those games.
• When it has played as a moneyline underdog with odds of +142 or longer, Chicago has a 24-50 record (winning only 32.4% of its games).
• The White Sox have combined with opponents to hit the over on the total 67 times this season for a 67-68-8 record against the over/under.
• The White Sox have an 82-61-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 152 hits and an OBP of .356 this season. He has a .283 batting average and a slugging percentage of .504.
• Among the qualifying batters in the majors, his batting average ranks 19th, his on-base percentage ranks 27th, and he is 17th in slugging.
• Steven Kwan leads Cleveland in slugging percentage (.378) thanks to 37 extra-base hits. He's batting .275 with an on-base percentage of .334.
• He is 30th in batting average, 62nd in on-base percentage and 128th in slugging among qualified hitters.
• Kyle Manzardo has collected 99 base hits, an OBP of .323 and a slugging percentage of .472 this season.
• Angel Martinez has 11 home runs, 42 RBI and a batting average of .226 this season.

White Sox Player Leaders

• Miguel Vargas has a team-best .314 on-base percentage. He's batting .231 and slugging .399.
• Including all the qualifying players in the big leagues, his batting average ranks 132nd, his on-base percentage is 106th, and he is 104th in slugging.
• Andrew Benintendi has 16 doubles, two triples, 19 home runs and 37 walks while hitting .246. He's slugging .435 with an on-base percentage of .309.
• Lenyn Sosa has put up a slugging percentage of .432 and has 124 hits, both team-best numbers for the White Sox.
• Chase Meidroth has 15 doubles, four home runs and 43 walks while hitting .269.

Guardians vs White Sox Head to Head

• 9/12/2025: 4-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/10/2025: 6-4 CHW (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/9/2025: 3-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/8/2025: 9-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/13/2025: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/12/2025: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/11/2025: 5-4 CHW (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/10/2025: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/9/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)

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