Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 13

Odds updated as of 2:12 a.m.

The Cleveland Guardians versus the Chicago White Sox is on the MLB schedule for Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Guardians vs White Sox Game Info

• Cleveland Guardians (76-71) vs. Chicago White Sox (57-91)
• Date: Saturday, September 13, 2025
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and CHSN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-168) | CHW: (+142)
• Spread: CLE: -1.5 (+128) | CHW: +1.5 (-154)
• Total: 8 -- Over: (-104) | Under: (-118)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 2-0, 1.93 ERA vs Davis Martin (White Sox) - 6-9, 4.03 ERA

The Guardians will call on Parker Messick (2-0) versus the White Sox and Davis Martin (6-9). Messick's team is 2-2-0 against the spread this season in his starts. Messick's team won his only start as a favorite this season. The White Sox have an 11-10-0 record against the spread in Martin's starts. The White Sox have an 8-13 record in Martin's 21 starts this season when they were the underdog on the moneyline.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (56.7%)

Guardians vs White Sox Moneyline

• Chicago is a +142 underdog on the moneyline, while Cleveland is a -168 favorite at home.

Guardians vs White Sox Spread

• The White Sox are +1.5 on the spread (-154 to cover), and Cleveland is +128 to cover the runline.

Guardians vs White Sox Over/Under

• A combined run total of 8 has been set for Guardians-White Sox on Sept. 13, with the over at -104 and the under at -118.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have been victorious in 38, or 63.3%, of the 60 contests they have been chosen as favorites in this season.
• This season Cleveland has been victorious seven times in eight chances when named as a favorite of at least -168 on the moneyline.
• Contests with the Guardians have gone over the total set by bookmakers in 63 of 144 chances this season.
• The Guardians are 77-67-0 against the spread in their 144 games that had a posted line this season.
• The White Sox have been the moneyline underdog 140 total times this season. They've finished 53-87 in those games.
• Chicago has a 24-50 record (winning just 32.4% of its games) when it has played as a moneyline underdog of +142 or longer.
• The White Sox have played in 143 games with a set over/under, and have combined with their opponents to go over the total 67 times (67-68-8).
• The White Sox have an 82-61-0 record ATS this season (covering 57.3% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland in OBP (.356) and total hits (152) this season. He's batting .283 batting average while slugging .504.
• He ranks 19th in batting average, 27th in on-base percentage, and 17th in slugging among qualified hitters in MLB.
• Steven Kwan leads Cleveland in slugging percentage (.378) thanks to 37 extra-base hits. He's batting .275 with an on-base percentage of .334.
• He is 30th in batting average, 62nd in on-base percentage and 128th in slugging among qualifying hitters.
• Kyle Manzardo has collected 99 base hits, an OBP of .323 and a slugging percentage of .472 this season.
• Angel Martinez has been key for Cleveland with 93 hits, an OBP of .267 plus a slugging percentage of .363.

White Sox Player Leaders

• Miguel Vargas has put up an on-base percentage of .314, a team-best for the White Sox. He's batting .231 and slugging .399.
• He ranks 132nd in batting average, 106th in on-base percentage and 104th in slugging percentage among all qualified hitters in the majors.
• Andrew Benintendi is hitting .246 with 16 doubles, two triples, 19 home runs and 37 walks. He's slugging .435 with an on-base percentage of .309.
• Lenyn Sosa has a team-high slugging percentage (.432) and paces the White Sox in hits (124).
• Chase Meidroth has 15 doubles, four home runs and 43 walks while batting .269.

Guardians vs White Sox Head to Head

• 9/12/2025: 4-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/10/2025: 6-4 CHW (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/9/2025: 3-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/8/2025: 9-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/13/2025: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/12/2025: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/11/2025: 5-4 CHW (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/10/2025: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/9/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)

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