Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 6:13 p.m.

The Cleveland Guardians are among the MLB teams in action on Friday, up against the Chicago White Sox.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs White Sox Game Info

• Cleveland Guardians (75-71) vs. Chicago White Sox (57-90)
• Date: Friday, September 12, 2025
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and CHSN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-142) | CHW: (+120)
• Spread: CLE: -1.5 (+146) | CHW: +1.5 (-176)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 9-11, 4.69 ERA vs Martín Pérez (White Sox) - 1-4, 3.15 ERA

The Guardians will give the ball to Tanner Bibee (9-11, 4.69 ERA), who is eyeing win No. 10 on the season, and the White Sox will counter with Martin Perez (1-4, 3.15 ERA). When Bibee starts, his team is 16-11-0 against the spread this season. Bibee's team has been victorious in 64.3% of the games he's started as the moneyline favorite with a record of 9-5. The White Sox have gone 6-2-0 against the spread when Perez starts. The White Sox are 3-5 in Pérez's eight starts this season that they were the underdog on the moneyline.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.7%)

Guardians vs White Sox Moneyline

• Cleveland is a -142 favorite on the moneyline, while Chicago is a +120 underdog on the road.

Guardians vs White Sox Spread

• The Guardians are hosting the White Sox and are favored by 1.5 runs (+146 to cover) on the runline. Chicago is -176 to cover.

Guardians vs White Sox Over/Under

• A total of 7.5 runs has been set for the Guardians-White Sox game on Sept. 12, with the over available at -110 and the under at -110.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have come away with 37 wins in the 59 contests they have been listed as the favorites in this season.
• This year Cleveland has won 10 of 14 games when listed as at least -142 on the moneyline.
• Contests with the Guardians have gone over the total set by bookmakers in 63 of 143 chances this season.
• The Guardians have an against the spread mark of 76-67-0 in 143 games with a line this season.
• The White Sox have a 53-86 record in games they were listed as the moneyline underdog (winning 38.1% of those games).
• Chicago has a 37-68 record (winning just 35.2% of its games) when playing as a moneyline underdog of +120 or longer.
• The White Sox have combined with opponents to go over the total 67 times this season for a 67-67-8 record against the over/under.
• The White Sox have covered 57.7% of their games this season, going 82-60-0 against the spread.

Guardians Player Leaders

• Jose Ramirez has 152 hits and an OBP of .358, both of which are tops among Cleveland hitters this season. He has a .285 batting average and a slugging percentage of .507.
• Among qualified hitters in baseball, he ranks 17th in batting average, 23rd in on-base percentage, and 16th in slugging.
• Steven Kwan has hit 10 homers this season while driving in 48 runs. He's batting .276 this season and slugging .380 with an on-base percentage of .335.
• Among all qualified, he is 30th in batting average, 61st in on-base percentage and 124th in slugging percentage.
• Kwan brings a two-game streak with at least one hit into this contest. In his last five games he is hitting .300 with a double, three walks and an RBI.
• Kyle Manzardo is batting .240 with a .476 slugging percentage and 67 RBI this year.
• Manzardo has recorded a hit in four games in a row. In his last five games he is batting .375 with a double, a home run, three walks and four RBIs.
• Angel Martinez has 10 home runs, 41 RBI and a batting average of .225 this season.

White Sox Player Leaders

• Miguel Vargas has racked up an on-base percentage of .316, a team-best for the White Sox. He's batting .233 and slugging .401.
• Including all qualified hitters in the majors, he ranks 130th in batting average, 103rd in on-base percentage and 104th in slugging percentage.
• Andrew Benintendi has 16 doubles, two triples, 19 home runs and 37 walks while hitting .248. He's slugging .438 with an on-base percentage of .311.
• Lenyn Sosa has racked up 124 hits with a .436 slugging percentage, both team-best marks for the White Sox.
• Chase Meidroth is batting .269 with 15 doubles, four home runs and 43 walks.

Guardians vs White Sox Head to Head

• 8/10/2025: 6-4 CHW (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/9/2025: 3-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/8/2025: 9-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/13/2025: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/12/2025: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/11/2025: 5-4 CHW (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/10/2025: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/9/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/8/2025: 1-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)

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