Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for July 12

Odds updated as of 3:11 p.m.

MLB action on Saturday includes the Cleveland Guardians taking on the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Guardians vs White Sox Game Info

• Cleveland Guardians (44-49) vs. Chicago White Sox (32-63)
• Date: Saturday, July 12, 2025
• Time: 4:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and CLEG

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | CHW: (+110)
• Spread: CLE: -1.5 (+130) | CHW: +1.5 (-156)
• Total: 8 -- Over: (-115) | Under: (-105)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 4-9, 4.27 ERA vs Sean Burke (White Sox) - 4-8, 4.40 ERA

The probable pitchers are Tanner Bibee (4-9) for the Guardians and Sean Burke (4-8) for the White Sox. When Bibee starts, his team is 9-8-0 against the spread this season. Bibee's team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 4-4. The White Sox have a 10-5-0 record against the spread in Burke's starts. The White Sox have a 7-8 record in Burke's 15 starts this season when they were the moneyline underdog.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.7%)

Guardians vs White Sox Moneyline

• Cleveland is the favorite, -130 on the moneyline, while Chicago is a +110 underdog despite being at home.

Guardians vs White Sox Spread

• The Guardians are at the White Sox and are favored by 1.5 runs on the spread. The Guardians are +130 to cover the runline, with the White Sox being -156.

Guardians vs White Sox Over/Under

• The over/under for Guardians-White Sox on July 12 is 8. The over is -115, and the under is -105.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have come away with 18 wins in the 31 contests they have been listed as the favorites in this season.
• This season Cleveland has come away with a win 10 times in 15 chances when named as a favorite of at least -130 on the moneyline.
• The Guardians and their opponents have hit the over in 39 of their 91 games with a total set by oddsmakers this season.
• The Guardians have an against the spread record of 46-45-0 in 91 games with a line this season.
• The White Sox have compiled a 29-60 record in games they were the underdog on the moneyline (winning 32.6% of those games).
• When it has played as a moneyline underdog with odds of +110 or longer, Chicago has a record of 28-55 (33.7%).
• The White Sox have played in 92 games with an over/under set, and have combined with opponents to go over the total 39 times (39-48-5).
• The White Sox have a 49-43-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez has 101 hits and an OBP of .364, both of which lead Cleveland hitters this season. He has a .297 batting average and a slugging percentage of .512.
• Among all qualified hitters in the majors, he ranks 10th in batting average, 27th in on-base percentage, and 16th in slugging.
• Steven Kwan has hit six homers this season while driving in 29 runs. He's batting .287 this season and slugging .400 with an on-base percentage of .346.
• Among qualifying batters, he ranks 21st in batting average, 56th in on-base percentage and 106th in slugging percentage.
• Carlos Santana has collected 70 base hits, an OBP of .327 and a slugging percentage of .362 this season.
• Angel Martinez is batting .242 with a .267 OBP and 33 RBI for Cleveland this season.
• Martinez brings an eight-game hitting streak into this game. In his last 10 outings he is hitting .278 with five doubles, three home runs, two walks and seven RBIs.

White Sox Player Leaders

• Miguel Vargas has put up an on-base percentage of .299 and has 73 hits, both team-best numbers for the White Sox. He's batting .219 and slugging .383.
• Including all the qualifying players in MLB, his batting average is 144th, his on-base percentage ranks 131st, and he is 123rd in slugging.
• Andrew Benintendi is batting .218 with 10 doubles, two triples, 10 home runs and 20 walks. He's slugging .406 with an on-base percentage of .280.
• Lenyn Sosa has a .427 slugging percentage, which leads the White Sox.
• Chase Meidroth is batting .248 with six doubles, two home runs and 32 walks.

Guardians vs White Sox Head to Head

• 7/11/2025: 5-4 CHW (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/10/2025: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/9/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/8/2025: 1-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/11/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/10/2024: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/9/2024: 5-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/4/2024: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 7/3/2024: 8-2 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -215, Underdog Moneyline: +180)

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