Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 4:15 p.m.

The Cleveland Guardians versus the Minnesota Twins is on the MLB schedule for Saturday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Twins Game Info

• Cleveland Guardians (82-71) vs. Minnesota Twins (66-87)
• Date: Saturday, September 20, 2025
• Time: 7:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and CLEG

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-112) | MIN: (-104)
• Spread: CLE: -1.5 (+146) | MIN: +1.5 (-176)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Logan Allen (Guardians) - 7-11, 4.36 ERA vs Bailey Ober (Twins) - 5-8, 5.12 ERA

The Guardians will give the ball to Logan Allen (7-11, 4.36 ERA), who is eyeing win No. 8 on the season, and the Twins will turn to Bailey Ober (5-8, 5.12 ERA). Allen's team is 13-13-0 against the spread in his starts this season. Allen's team has a record of 6-4 this season when he starts and they are the favorite on the moneyline. The Twins have gone 11-12-0 against the spread when Ober starts. The Twins are 5-6 in Ober's 11 starts this season that they were the underdog on the moneyline.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (62.8%)

Guardians vs Twins Moneyline

• Cleveland is the favorite, -112 on the moneyline, while Minnesota is a -104 underdog despite being at home.

Guardians vs Twins Spread

• The Guardians are at the Twins and are favored by 1.5 runs on the spread. The Guardians are +146 to cover the runline, with the Twins being -176.

Guardians vs Twins Over/Under

• The Guardians-Twins contest on Sept. 20 has been given an over/under of 7.5 runs. The over is set at -120 and the under at -102.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have been chosen as favorites in 63 games this year and have walked away with the win 41 times (65.1%) in those games.
• This year Cleveland has won 39 of 60 games when listed as at least -112 on the moneyline.
• The Guardians and their opponents have hit the over in 65 of their 150 games with a total set by oddsmakers this season.
• In 150 games with a line this season, the Guardians have a mark of 82-68-0 against the spread.
• The Twins have won 22 of the 59 games they were the underdog on the moneyline this season (37.3%).
• Minnesota has gone 21-36 when playing as a moneyline underdog with odds of -104 or longer (36.8%).
• The Twins have played in 148 games with a set over/under, and have combined with opponents to go over the total 72 times (72-69-7).
• The Twins have covered 48% of their games this season, going 71-77-0 against the spread.

Guardians Player Leaders

• Jose Ramirez has 158 hits and an OBP of .359, both of which are best among Cleveland hitters this season. He has a .282 batting average and a slugging percentage of .504.
• He ranks 22nd in batting average, 23rd in on-base percentage, and 15th in slugging among all qualified batters in the majors.
• Ramirez has recorded a base hit in two games in a row. During his last five outings he is hitting .333 with two doubles, a home run, five walks and three RBIs.
• Steven Kwan has hit 10 homers this season while driving in 50 runs. He's batting .273 this season and slugging .375 with an on-base percentage of .333.
• Among all qualified hitters, he ranks 35th in batting average, 64th in on-base percentage and 129th in slugging percentage.
• Kyle Manzardo has 104 hits this season and has a slash line of .238/.321/.465.
• Angel Martinez has 11 home runs, 45 RBI and a batting average of .230 this season.
• Martinez has hit safely in five straight games. During his last five outings he is batting .357 with two doubles, a triple, two walks and three RBIs.

Twins Player Leaders

• Byron Buxton has accumulated an on-base percentage of .331, a slugging percentage of .546, and has 122 hits, all club-bests for the Twins (while batting .268).
• Including all the qualified players in MLB, his batting average is 42nd, his on-base percentage ranks 67th, and he is sixth in slugging.
• Trevor Larnach is slugging .408 to pace his team. He has a batting average of .253 with an on-base percentage of .328.
• His batting average ranks 87th among all qualified players, his on-base percentage is 74th, and he is 92nd in slugging.
• Brooks Lee is batting .240 with 15 doubles, a triple, 15 home runs and 30 walks.
• Royce Lewis is hitting .240 with 16 doubles, 12 home runs and 25 walks.

Guardians vs Twins Head to Head

• 9/19/2025: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/3/2025: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 8/2/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/1/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/21/2025: 5-1 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/1/2025: 4-3 CLE (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/30/2025: 4-2 CLE (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/28/2025: 11-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2024: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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