Guardians vs Tigers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 6:12 p.m.

The Cleveland Guardians will take on the Detroit Tigers in MLB action on Thursday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Guardians vs Tigers Game Info

• Cleveland Guardians (86-72) vs. Detroit Tigers (85-73)
• Date: Thursday, September 25, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and FDSDET

Guardians vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-158) | DET: (+134)
• Spread: CLE: -1.5 (+140) | DET: +1.5 (-170)
• Total: 7.5 -- Over: (-108) | Under: (-112)

Guardians vs Tigers Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 3-0, 2.08 ERA vs Troy Melton (Tigers) - 3-2, 2.79 ERA

This contest's pitching matchup is set, as the Guardians will send Parker Messick (3-0) to the mound, while Troy Melton (3-2) will get the nod for the Tigers. Messick's team is 4-2-0 against the spread this season in his starts. Messick and his team have won each of the three games he's started as the moneyline favorite. The Tigers are 1-2-0 ATS in Melton's three starts with a set spread. The Tigers have not been a moneyline underdog when Melton starts this season.

Guardians vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (53.8%)

Guardians vs Tigers Moneyline

• The Guardians vs Tigers moneyline has Cleveland as a -158 favorite, while Detroit is a +134 underdog on the road.

Guardians vs Tigers Spread

• The Tigers are at +1.5 on the runline against the Guardians. The Tigers are -170 to cover the spread, and the Guardians are +140.

Guardians vs Tigers Over/Under

• A total of 7.5 runs has been set for the Guardians-Tigers contest on Sept. 25, with the over available at -108 and the under at -112.

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Guardians vs Tigers Betting Trends

• The Guardians have won in 42, or 64.6%, of the 65 contests they have been named as odds-on favorites in this year.
• This season Cleveland has come away with a win 10 times in 12 chances when named as a favorite of at least -158 on the moneyline.
• The Guardians' games have gone over the total in 66 of their 154 opportunities.
• The Guardians are 85-69-0 against the spread in their 154 games that had a posted line this season.
• The Tigers are 20-21 in games they were the underdog on the moneyline (winning 48.8% of those games).
• Detroit has a 4-6 record (winning 40% of its games) when playing as a moneyline underdog of +134 or longer.
• The Tigers have combined with opponents to go over the total 78 times this season for a 78-67-6 record against the over/under.
• The Tigers have put together a 70-81-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez has 164 hits and an OBP of .360, both of which lead Cleveland hitters this season. He has a .284 batting average and a slugging percentage of .507.
• He is 20th in batting average, 21st in on-base percentage, and 14th in slugging among all qualifying batters in the majors.
• Ramirez hopes to build on a seven-game hitting streak in this matchup. During his last 10 outings he is batting .333 with four doubles, two home runs, seven walks and seven RBIs.
• Steven Kwan has hit 11 homers this season while driving in 56 runs. He's batting .277 this season and slugging .382 with an on-base percentage of .335.
• Among qualifying batters, he is 30th in batting average, 60th in on-base percentage and 121st in slugging percentage.
• Kwan brings a six-game streak with at least one hit into this contest. During his last 10 outings he is batting .310 with three doubles, a home run, three walks and eight RBIs.
• Kyle Manzardo has collected 107 base hits, an OBP of .315 and a slugging percentage of .453 this season.
• Angel Martinez has 11 home runs, 45 RBI and a batting average of .228 this season.

Tigers Player Leaders

• Gleyber Torres has an on-base percentage of .363, a team-high for the Tigers. He's batting .259 and slugging .394.
• He ranks 70th in batting average, 15th in on-base percentage and 110th in slugging percentage among all qualifying hitters in MLB.
• Riley Greene has collected 154 hits while slugging .496. Both pace his team. He has a batting average of .261 with an on-base percentage of .316.
• Including all qualified hitters, his batting average places him 63rd, his on-base percentage is 100th, and he is 18th in slugging.
• Spencer Torkelson has 27 doubles, a triple, 31 home runs and 70 walks while batting .241.
• Zach McKinstry has 23 doubles, 11 triples, 12 home runs and 46 walks while hitting .260.

Guardians vs Tigers Head to Head

• 9/23/2025: 5-2 CLE (Favorite: Tigers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/18/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/17/2025: 4-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/6/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/5/2025: 1-0 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/25/2025: 5-0 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/24/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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