Guardians vs Tigers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 7:15 a.m.

Thursday's slate in the MLB includes a matchup between the Cleveland Guardians and the Detroit Tigers.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Tigers Game Info

• Cleveland Guardians (86-72) vs. Detroit Tigers (85-73)
• Date: Thursday, September 25, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and FDSDET

Guardians vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-164) | DET: (+138)
• Spread: CLE: -1.5 (+128) | DET: +1.5 (-154)
• Total: 7.5 -- Over: (-122) | Under: (-100)

Guardians vs Tigers Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 3-0, 2.08 ERA vs TBA (Tigers)

Parker Messick (3-0) will start for the Guardians in this matchup. The Tigers, however, have yet to list a starter. Messick and his team have a record of 4-2-0 against the spread when he starts. Messick's team has won each of the three games he's started as the moneyline favorite.

Guardians vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (56.6%)

Guardians vs Tigers Moneyline

• Detroit is a +138 underdog on the moneyline, while Cleveland is a -164 favorite at home.

Guardians vs Tigers Spread

• The Tigers are at +1.5 on the runline against the Guardians. The Tigers are -154 to cover the spread, and the Guardians are +128.

Guardians vs Tigers Over/Under

• Guardians versus Tigers on Sept. 25 has an over/under of 7.5 runs, with the odds on the over -122 and the under set at -100.

Bet on Cleveland Guardians vs. Detroit Tigers on FanDuel today!

Guardians vs Tigers Betting Trends

• The Guardians have come away with 42 wins in the 65 contests they have been listed as the favorites in this season.
• Cleveland has a record of 8-1 when favored by -164 or more this year.
• Contests with the Guardians have gone over the total set by oddsmakers in 66 of 154 chances this season.
• The Guardians have posted a record of 85-69-0 against the spread this season.
• The Tigers have a 20-21 record in games they were the underdog on the moneyline (winning 48.8% of those games).
• Detroit is 3-5 (winning only 37.5% of its games) when it has played as a moneyline underdog of +138 or longer.
• The Tigers have combined with opponents to hit the over on the total 78 times this season for a 78-67-6 record against the over/under.
• The Tigers have gone 70-81-0 ATS this season.

Guardians Player Leaders

• Jose Ramirez has 164 hits and an OBP of .360, both of which are tops among Cleveland hitters this season. He has a .284 batting average and a slugging percentage of .507.
• Among all qualified batters, he ranks 20th in batting average, his on-base percentage ranks 20th, and he is 14th in slugging.
• Ramirez hopes to build on a seven-game hitting streak in this matchup. During his last 10 outings he is hitting .333 with four doubles, two home runs, seven walks and seven RBIs.
• Steven Kwan leads Cleveland in slugging percentage (.382) thanks to 41 extra-base hits. He's batting .277 with an on-base percentage of .335.
• Among all qualified, he ranks 30th in batting average, 60th in on-base percentage and 121st in slugging percentage.
• Kwan takes a six-game streak with at least one hit into this contest. During his last 10 outings he is batting .310 with three doubles, a home run, three walks and eight RBIs.
• Kyle Manzardo is batting .234 with a .453 slugging percentage and 68 RBI this year.
• Angel Martinez is batting .228 with a .270 OBP and 45 RBI for Cleveland this season.

Tigers Player Leaders

• Gleyber Torres has racked up a team-high .363 on-base percentage. He's batting .259 and slugging .394.
• He ranks 69th in batting average, 15th in on-base percentage and 110th in slugging percentage among all qualified batters in the majors.
• Riley Greene's 154 hits and .496 slugging percentage both pace his team. He has a batting average of .261 with an on-base percentage of .316.
• Including all qualified hitters, his batting average puts him 63rd, his on-base percentage is 100th, and he is 18th in slugging.
• Spencer Torkelson is batting .241 with 27 doubles, a triple, 31 home runs and 70 walks.
• Zach McKinstry is batting .260 with 23 doubles, 11 triples, 12 home runs and 46 walks.

Guardians vs Tigers Head to Head

• 9/23/2025: 5-2 CLE (Favorite: Tigers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/18/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/17/2025: 4-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/6/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/5/2025: 1-0 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/25/2025: 5-0 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/24/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!