Angels vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 9:12 p.m.

The Kansas City Royals will take on the Los Angeles Angels in MLB action on Thursday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Royals vs Angels Game Info

• Kansas City Royals (79-79) vs. Los Angeles Angels (71-87)
• Date: Thursday, September 25, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and FDSKC

Royals vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-132) | LAA: (+112)
• Spread: KC: -1.5 (+126) | LAA: +1.5 (-152)
• Total: 9.5 -- Over: (-100) | Under: (-122)

Royals vs Angels Probable Starting Pitchers

Probable Pitchers: Michael Lorenzen (Royals) - 6-11, 4.70 ERA vs Mitch Farris (Angels) - 1-2, 6.52 ERA

The Royals will call on Michael Lorenzen (6-11) versus the Angels and Mitch Farris (1-2). Lorenzen's team is 15-10-0 against the spread in his starts this season. Lorenzen's team has a record of 6-4 this season when he starts and they are the favorite on the moneyline. The Angels have a 2-2-0 ATS record in Farris' four starts that had a set spread. The Angels are 2-1 in Farris' three starts this season that they were the underdog on the moneyline.

Royals vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (54.9%)

Royals vs Angels Moneyline

• Los Angeles is the underdog, +112 on the moneyline, while Kansas City is a -132 favorite despite being on the road.

Royals vs Angels Spread

• The Royals are 1.5-run road favorites on the runline against the Angels. The Royals are +126 to cover, and the Angels are -152.

Royals vs Angels Over/Under

• Royals versus Angels on Sept. 25 has an over/under of 9.5 runs, with the odds on the over -100 and the under set at -122.

Bet on Kansas City Royals vs. Los Angeles Angels on FanDuel today!

Royals vs Angels Betting Trends

• The Royals have been favorites in 65 games this season and have come away with the win 37 times (56.9%) in those contests.
• This year Kansas City has won 22 of 39 games when listed as at least -132 on the moneyline.
• The Royals and their opponents have gone over the total this season in 68 of their 156 opportunities.
• The Royals are 76-80-0 against the spread in their 156 games that had a posted line this season.
• The Angels are 51-66 in games they were listed as the moneyline underdog (winning 43.6% of those games).
• In games it has played as a moneyline underdog with odds of +112 or longer, Los Angeles has a 39-53 record (winning 42.4% of its games).
• The Angels have combined with opponents to hit the over on the total 83 times this season for an 83-68-5 record against the over/under.
• The Angels are 82-74-0 against the spread this season.

Royals Player Leaders

• Bobby Witt Jr. leads Kansas City in slugging percentage (.498) and total hits (176) this season. He's batting .291 with an on-base percentage of .349.
• Among all qualifying hitters in the majors, he is 13th in batting average, 39th in on-base percentage, and 17th in slugging.
• Maikel Garcia leads Kansas City with an OBP of .352 this season while batting .286 with 60 walks and 77 runs scored. He's slugging .452.
• Among qualified hitters, his batting average ranks him 19th, his on-base percentage 34th, and his slugging percentage 58th.
• Vinnie Pasquantino is batting .267 with a .476 slugging percentage and 108 RBI this year.
• Salvador Perez has been key for Kansas City with 140 hits, an OBP of .285 plus a slugging percentage of .454.

Angels Player Leaders

• Taylor Ward has racked up a team-best .477 slugging percentage. He's batting .228 with an on-base percentage of .315.
• Including all qualified hitters in MLB, his batting average places him 137th, his on-base percentage ranks 104th, and he is 32nd in slugging.
• Ward enters this game on a seven-game hitting streak. In his last 10 outings he is hitting .282 with six home runs and six RBIs.
• Nolan Schanuel has a .356 OBP to lead his team. He has a batting average of .267 while slugging .388.
• He is currently 44th in batting average, 28th in on-base percentage and 117th in slugging percentage among all qualifying batters.
• Jo Adell has racked up 120 hits, a team-high for the Angels.
• Mike Trout paces his team with a .356 on-base percentage.

Royals vs Angels Head to Head

• 9/24/2025: 3-2 LAA (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/23/2025: 8-4 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/4/2025: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/3/2025: 4-3 LAA (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/2/2025: 5-1 LAA (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 8/21/2024: 3-0 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 8/20/2024: 9-5 LAA (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/19/2024: 5-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/12/2024: 4-2 KC (Favorite: Angels, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/11/2024: 9-3 LAA (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -164, Underdog Moneyline: +138)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!