Guardians vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for April 28

Odds updated as of 1:11 a.m.

The Tuesday slate in MLB includes a matchup between the Cleveland Guardians and the Tampa Bay Rays.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Guardians vs Rays Game Info

• Cleveland Guardians (15-15) vs. Tampa Bay Rays (17-11)
• Date: Tuesday, April 28, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Rays.TV

Guardians vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | TB: (+110)
• Spread: CLE: -1.5 (+158) | TB: +1.5 (-192)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Guardians vs Rays Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 0-3, 4.45 ERA vs Nick Martínez (Rays) - 1-1, 2.10 ERA

This contest's pitching matchup is set, as the Guardians will send Tanner Bibee (0-3) to the mound, while Nick Martinez (1-1) will answer the bell for the Rays. Bibee and his team are 1-5-0 ATS this season when he starts. Bibee has started three games with his team as the moneyline favorite, and has been upset each time. The Rays have a 4-1-0 ATS record in Martínez's five starts that had a set spread. The Rays are 3-1 in Martínez's four starts this season that they were the moneyline underdog.

Guardians vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (54.6%)

Guardians vs Rays Moneyline

• Cleveland is the favorite, -130 on the moneyline, while Tampa Bay is a +110 underdog on the road.

Guardians vs Rays Spread

• The Guardians are hosting the Rays and are favored by 1.5 runs (+158 to cover) on the runline. Tampa Bay is -192 to cover.

Guardians vs Rays Over/Under

• An over/under of 7.5 has been set for Guardians-Rays on April 28, with the over being -110 and the under -110.

Bet on Cleveland Guardians vs. Tampa Bay Rays on FanDuel today!

Guardians vs Rays Betting Trends

• The Guardians have been favorites in 13 games this season and have come away with the win seven times (53.8%) in those contests.
• This year Cleveland has won three of seven games when listed as at least -130 on the moneyline.
• The Guardians and their opponents have hit the over in 15 of their 30 games with a total set by oddsmakers this season.
• The Guardians are 16-14-0 against the spread in their 30 games that had a posted line this season.
• The Rays have won 53.8% of the games this season they were the moneyline underdog (7-6).
• Tampa Bay is 5-1 (winning 83.3% of its games) when it has played as a moneyline underdog of +110 or longer.
• In the 28 games bookmakers have set an over/under for the Rays, they have combined with opponents to go over the total 17 times (17-11-0).
• The Rays have covered 60.7% of their games this season, going 17-11-0 ATS.

Guardians Player Leaders

• Jose Ramirez has an OPS of .803, fueled by an OBP of .354 to go with a slugging percentage of .450. He has a .229 batting average, as well.
• Among all qualified hitters in baseball, he is 121st in batting average, 54th in on-base percentage, and 59th in slugging.
• Chase DeLauter is batting .245 with six doubles, a triple, five home runs and 13 walks. He's slugging .489 with an on-base percentage of .333.
• He is 85th in batting average, 83rd in on-base percentage and 34th in slugging among qualified hitters.
• DeLauter has picked up at least one hit in three games in a row. During his last five outings he is batting .353 with a double, a walk and an RBI.
• Brayan Rocchio has hit three homers with a team-high .398 SLG this season.
• Angel Martinez leads Cleveland with 24 hits, batting .276 this season with 10 extra-base hits.

Rays Player Leaders

• Yandy Diaz has accumulated an on-base percentage of .424 and a slugging percentage of .486. Both lead the Rays. He's batting .327.
• Including all the qualified hitters in the big leagues, he ranks sixth in batting average, fourth in on-base percentage and 36th in slugging percentage.
• Junior Caminero paces his team with 29 hits. He has a batting average of .259 while slugging .500 with an on-base percentage of .333.
• Including all qualified hitters, he ranks 68th in batting average, 83rd in on-base percentage and 29th in slugging percentage.
• Jonathan Aranda is hitting .228 with four doubles, seven home runs and 19 walks.
• Chandler Simpson is hitting .309 with two triples and six walks.

Guardians vs Rays Head to Head

• 4/27/2026: 3-2 TB (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/7/2025: 2-1 CLE (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/6/2025: 3-2 CLE (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/5/2025: 7-1 CLE (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/4/2025: 4-2 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/27/2025: 4-3 CLE (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/26/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)

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