Guardians vs Rangers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 6:13 p.m.

The Friday slate in MLB includes a matchup between the Cleveland Guardians and the Texas Rangers.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Rangers Game Info

• Cleveland Guardians (86-73) vs. Texas Rangers (80-79)
• Date: Friday, September 26, 2025
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: MLB Network, CLEG, and Victory+

Guardians vs Rangers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-154) | TEX: (+130)
• Spread: CLE: -1.5 (+138) | TEX: +1.5 (-166)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Guardians vs Rangers Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 7-6, 4.15 ERA vs Jack Leiter (Rangers) - 9-10, 3.92 ERA

The Guardians will give the ball to Slade Cecconi (7-6, 4.15 ERA), who is eyeing win No. 8 on the season, and the Rangers will counter with Jack Leiter (9-10, 3.92 ERA). Cecconi's team is 13-8-0 against the spread in his starts this season. Cecconi's team has a record of 6-3 this season when he starts and they are the favorite on the moneyline. The Rangers have a 16-12-0 record against the spread in Leiter's starts. The Rangers have been the moneyline underdog in 19 of Leiter's starts this season, and they went 5-14 in those matchups.

Guardians vs Rangers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rangers win (50.3%)

Guardians vs Rangers Moneyline

• The moneyline numbers for Guardians vs. Rangers reveal Cleveland as the favorite (-154) and Texas as the underdog (+130) on the road.

Guardians vs Rangers Spread

• The Guardians are 1.5-run home favorites on the runline against the Rangers. The Guardians are +138 to cover, and the Rangers are -166.

Guardians vs Rangers Over/Under

• Guardians versus Rangers on Sept. 26 has an over/under of 7.5 runs, with the odds on the over -105 and the under set at -115.

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Guardians vs Rangers Betting Trends

• The Guardians have been chosen as favorites in 66 games this year and have walked away with the win 42 times (63.6%) in those games.
• This season Cleveland has come away with a win 11 times in 14 chances when named as a favorite of at least -154 on the moneyline.
• The Guardians' games have gone over the total in 66 of their 155 opportunities.
• The Guardians have an against the spread record of 85-70-0 in 155 games with a line this season.
• The Rangers have put together a 30-46 record in games they were listed as the moneyline underdog (winning 39.5% of those games).
• Texas has a 3-10 record (winning just 23.1% of its games) when it has played as a moneyline underdog of +130 or longer.
• The Rangers have combined with opponents to hit the over on the total 69 times this season for a 69-87-2 record against the over/under.
• The Rangers have put together an 83-75-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 165 hits and an OBP of .361 this season. He has a .284 batting average and a slugging percentage of .508.
• Among all qualified hitters in MLB, his batting average ranks 21st, his on-base percentage ranks 20th, and he is 14th in slugging.
• Ramirez will look for his ninth straight game with a hit in this contest. In his last 10 outings he is hitting .333 with five doubles, two home runs, seven walks and eight RBIs.
• Steven Kwan has hit 11 homers this season while driving in 56 runs. He's batting .275 this season and slugging .379 with an on-base percentage of .333.
• Among all qualified hitters, he ranks 32nd in batting average, 65th in on-base percentage and 125th in slugging percentage.
• Kyle Manzardo has collected 107 base hits, an OBP of .312 and a slugging percentage of .449 this season.
• Angel Martinez has been key for Cleveland with 99 hits, an OBP of .268 plus a slugging percentage of .362.

Rangers Player Leaders

• Josh Smith has accumulated a team-best .366 slugging percentage. He's batting .251 with an on-base percentage of .335.
• Including all qualifying players, he ranks 89th in batting average, while his on-base percentage is 60th and he is 136th in slugging.
• Adolis Garcia is batting .226 with 28 doubles, 18 home runs and 27 walks. He's slugging .391 with an on-base percentage of .270.
• Including all qualified hitters, his batting average places him 139th, his on-base percentage ranks 145th, and he is 116th in slugging.
• Josh Jung is hitting .249 with 21 doubles, a triple, 14 home runs and 26 walks.
• Jake Burger is hitting .236 with 15 doubles, a triple, 16 home runs and 12 walks.

Guardians vs Rangers Head to Head

• 8/24/2025: 5-0 TEX (Favorite: Rangers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/23/2025: 10-0 TEX (Favorite: Rangers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/22/2025: 4-3 TEX (Favorite: Rangers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 8/25/2024: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/24/2024: 13-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/23/2024: 5-3 TEX (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/15/2024: 4-0 TEX (Favorite: Rangers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/14/2024: 7-4 CLE (Favorite: Rangers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/13/2024: 7-0 CLE (Favorite: Rangers, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/17/2023: 9-2 CLE (Favorite: Rangers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

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