Guardians vs Rangers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 4:13 a.m.

The Friday schedule in MLB includes a matchup between the Cleveland Guardians and the Texas Rangers.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Rangers Game Info

• Cleveland Guardians (86-73) vs. Texas Rangers (80-79)
• Date: Friday, September 26, 2025
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: MLB Network, CLEG, and Victory+

Guardians vs Rangers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-148) | TEX: (+126)
• Spread: CLE: -1.5 (+138) | TEX: +1.5 (-166)
• Total: 7.5 -- Over: (-114) | Under: (-106)

Guardians vs Rangers Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 7-6, 4.15 ERA vs Jack Leiter (Rangers) - 9-10, 3.92 ERA

The probable starters are Slade Cecconi (7-6) for the Guardians and Jack Leiter (9-10) for the Rangers. Cecconi and his team are 13-8-0 ATS this season when he starts. Cecconi's team is 6-3 this season when he starts and they are the moneyline favorite. When Leiter starts, the Rangers are 16-12-0 against the spread. The Rangers have been the moneyline underdog in 19 of Leiter's starts this season, and they went 5-14 in those matchups.

Guardians vs Rangers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rangers win (51.2%)

Guardians vs Rangers Moneyline

• The moneyline numbers for Guardians vs. Rangers reveal Cleveland as the favorite (-148) and Texas as the underdog (+126) on the road.

Guardians vs Rangers Spread

• The Guardians are favored by 1.5 runs at home versus the Rangers. The Guardians are +138 to cover the spread, while the Rangers are -166.

Guardians vs Rangers Over/Under

• The over/under for the Guardians versus Rangers game on Sept. 26 has been set at 7.5, with -114 odds on the over and -106 odds on the under.

Bet on Cleveland Guardians vs. Texas Rangers on FanDuel today!

Guardians vs Rangers Betting Trends

• The Guardians have won in 42, or 63.6%, of the 66 contests they have been named as odds-on favorites in this year.
• Cleveland has a record of 11-4 when favored by -148 or more this year.
• The Guardians and their opponents have hit the over in 66 of their 155 games with a total set by oddsmakers this season.
• The Guardians have posted a record of 85-70-0 against the spread this season.
• The Rangers have won 39.5% of the games this season they were the moneyline underdog (30-46).
• In games it has played as a moneyline underdog with odds of +126 or longer, Texas has a 3-14 record (winning only 17.6% of its games).
• The Rangers have played in 158 games with a set over/under, and have combined with opponents to go over the total 69 times (69-87-2).
• The Rangers have gone 83-75-0 against the spread this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland in OBP (.361) and total hits (165) this season. He's batting .284 batting average while slugging .508.
• Among all qualifying hitters in the majors, his batting average ranks 21st, his on-base percentage ranks 20th, and he is 14th in slugging.
• Ramirez will look for his ninth straight game with a hit in this contest. During his last 10 outings he is batting .333 with five doubles, two home runs, seven walks and eight RBIs.
• Steven Kwan leads Cleveland in slugging percentage (.379) thanks to 41 extra-base hits. He's batting .275 with an on-base percentage of .333.
• His batting average ranks 32nd among qualified players, his on-base percentage 65th, and his slugging percentage 125th.
• Kyle Manzardo is batting .232 with a .449 slugging percentage and 68 RBI this year.
• Angel Martinez has 11 home runs, 45 RBI and a batting average of .226 this season.

Rangers Player Leaders

• Josh Smith has a team-best .366 slugging percentage. He's batting .251 with an on-base percentage of .335.
• Including all the qualifying hitters in MLB, he is 89th in batting average, 60th in on-base percentage and 136th in slugging percentage.
• Adolis Garcia is hitting .226 with 28 doubles, 18 home runs and 27 walks. He's slugging .391 with an on-base percentage of .270.
• Including all qualified players, he ranks 139th in batting average, 145th in on-base percentage and 116th in slugging percentage.
• Josh Jung has 21 doubles, a triple, 14 home runs and 26 walks while hitting .249.
• Jake Burger is batting .236 with 15 doubles, a triple, 16 home runs and 12 walks.

Guardians vs Rangers Head to Head

• 8/24/2025: 5-0 TEX (Favorite: Rangers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/23/2025: 10-0 TEX (Favorite: Rangers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/22/2025: 4-3 TEX (Favorite: Rangers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 8/25/2024: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/24/2024: 13-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/23/2024: 5-3 TEX (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/15/2024: 4-0 TEX (Favorite: Rangers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/14/2024: 7-4 CLE (Favorite: Rangers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/13/2024: 7-0 CLE (Favorite: Rangers, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/17/2023: 9-2 CLE (Favorite: Rangers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

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