Giants vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 27

Odds updated as of 4:13 a.m.

Friday's slate in the MLB includes a matchup between the San Francisco Giants and the Chicago White Sox.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Giants vs White Sox Game Info

• San Francisco Giants (44-37) vs. Chicago White Sox (26-55)
• Date: Friday, June 27, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and NBCS-BA

Giants vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-166) | CHW: (+140)
• Spread: SF: -1.5 (-100) | CHW: +1.5 (-118)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Giants vs White Sox Probable Starting Pitchers

Probable Pitchers: Landen Roupp (Giants) - 5-5, 3.79 ERA vs Aaron Civale (White Sox) - 1-4, 5.03 ERA

The Giants will look to Landen Roupp (5-5) versus the White Sox and Aaron Civale (1-4). Roupp's team is 5-10-0 against the spread in his starts this season. Roupp's team has a record of 4-2 this season when he starts and they are the favorite on the moneyline. The White Sox are 3-4-0 against the spread when Civale starts. The White Sox have a 1-4 record in Civale's five starts this season when they were the underdog on the moneyline.

Giants vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (60.3%)

Giants vs White Sox Moneyline

• Looking at the moneyline for White Sox-Giants, Chicago is the underdog at +140, and San Francisco is -166 playing on the road.

Giants vs White Sox Spread

• The White Sox are +1.5 on the spread (-118 to cover), and San Francisco is -100 to cover the runline.

Giants vs White Sox Over/Under

• Giants versus White Sox on June 27 has an over/under of 8.5 runs, with the odds on the over -110 and the under set at -110.

Bet on San Francisco Giants vs. Chicago White Sox on FanDuel today!

Giants vs White Sox Betting Trends

• The Giants have won in 30, or 55.6%, of the 54 contests they have been named as odds-on favorites in this year.
• San Francisco has a record of 7-7 in contests when sportsbooks favor them by -166 or more on the moneyline.
• Contests with the Giants have gone over the total set by oddsmakers in 37 of 81 chances this season.
• In 81 games with a line this season, the Giants have a mark of 35-46-0 against the spread.
• The White Sox have won 24 of the 77 games they were the underdog on the moneyline this season (31.2%).
• When playing as a moneyline underdog with odds of +140 or longer, Chicago has a 14-36 record (winning only 28% of its games).
• The White Sox have played in 78 games with a set over/under, and have combined with opponents to go over the total 36 times (36-38-4).
• The White Sox have covered 55.1% of their games this season, going 43-35-0 ATS.

Giants Player Leaders

• Rafael Devers leads San Francisco in OBP (.396) and total hits (83) this season. He's batting .270 batting average while slugging .502.
• Among qualified hitters, he ranks 56th in batting average, his on-base percentage ranks fourth, and he is 23rd in slugging.
• Jung Hoo Lee has 17 doubles, six triples, six home runs and 29 walks. He's batting .252 and slugging .412 with an on-base percentage of .322.
• Among qualified batters, his batting average ranks him 93rd, his on-base percentage 94th, and his slugging percentage 93rd.
• Heliot Ramos has an OPS of .825, fueled by an OBP of .358 and a team-best slugging percentage of .467 this season.
• Wilmer Flores is batting .243 with a .316 OBP and 54 RBI for San Francisco this season.

White Sox Player Leaders

• Miguel Vargas has racked up a team-best OBP (.314) and slugging percentage (.422), while leading the White Sox in hits (67, while batting .233).
• He is 128th in batting average, 109th in on-base percentage and 82nd in slugging percentage among all qualifying batters in MLB.
• Andrew Benintendi has nine doubles, two triples, nine home runs and 16 walks while batting .236. He's slugging .445 with an on-base percentage of .297.
• Chase Meidroth is hitting .264 with five doubles, two home runs and 27 walks.
• Luis Robert is hitting .185 with eight doubles, eight home runs and 29 walks.

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