Giants vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 11:12 p.m.

The MLB's Sunday slate includes the San Francisco Giants facing the Colorado Rockies.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Giants vs Rockies Game Info

• San Francisco Giants (80-81) vs. Colorado Rockies (43-118)
• Date: Sunday, September 28, 2025
• Time: 3:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and COLR

Giants vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-295) | COL: (+240)
• Spread: SF: -1.5 (-152) | COL: +1.5 (+126)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Giants vs Rockies Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 14-11, 3.30 ERA vs McCade Brown (Rockies) - 0-4, 7.54 ERA

This contest's pitching matchup is set, as the Giants will send Logan Webb (14-11) to the mound, while McCade Brown (0-4) will get the nod for the Rockies. Webb's team is 15-18-0 against the spread in his starts this season. When Webb starts a game and his team is the favorite on the moneyline, they have a record of 14-15. The Rockies are 2-3-0 against the spread when Brown starts. The Rockies were the moneyline underdog for five Brown starts this season -- they lost every game.

Giants vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (68.8%)

Giants vs Rockies Moneyline

• The Giants vs Rockies moneyline has San Francisco as a -295 favorite, while Colorado is a +240 underdog on the road.

Giants vs Rockies Spread

• The Giants are hosting the Rockies and are favored by 1.5 runs on the spread. The Giants are -152 to cover the runline, with the Rockies being +126.

Giants vs Rockies Over/Under

• The Giants-Rockies contest on Sept. 28 has been given an over/under of 7.5 runs. The over is set at -110 and the under at -110.

Bet on San Francisco Giants vs. Colorado Rockies on FanDuel today!

Giants vs Rockies Betting Trends

• The Giants have been victorious in 49, or 52.7%, of the 93 contests they have been chosen as favorites in this season.
• San Francisco has played as a favorite of -295 or more just one time this year and came away with a win in that game.
• The Giants and their opponents have gone over in 77 of their 160 games with a total set by sportsbooks this season.
• The Giants have posted a record of 75-85-0 against the spread this season.
• The Rockies have gone 38-113 in games they were listed as the moneyline underdog (winning 25.2% of those games).
• In games it has played as a moneyline underdog with odds of +240 or longer, Colorado has a 6-29 record (winning just 17.1% of its games).
• In the 156 games oddsmakers have set an over/under for the Rockies, they have combined with opponents to go over the total 69 times (69-82-5).
• The Rockies have put together a 63-93-0 record ATS this season (covering 40.4% of the time).

Giants Player Leaders

• Rafael Devers leads San Francisco with 152 hits and an OBP of .372 this season. He has a .252 batting average and a slugging percentage of .476.
• Among qualifying hitters, he ranks 89th in batting average, his on-base percentage ranks ninth, and he is 35th in slugging.
• Devers will look for his eighth straight game with a hit in this contest. In his last 10 games he is hitting .211 with two doubles, three home runs, eight walks and six RBIs.
• Willy Adames has 22 doubles, two triples, 29 home runs and 80 walks. He's batting .224 and slugging .417 with an on-base percentage of .318.
• Among all qualifying players, he ranks 142nd in batting average, 97th in on-base percentage and 85th in slugging percentage.
• Jung Hoo Lee has collected 146 base hits, an OBP of .325 and a slugging percentage of .405 this season.
• Heliot Ramos has an OPS of .730, fueled by an OBP of .329 and a team-best slugging percentage of .402 this season.
• Ramos takes a five-game hitting streak into this game. In his last five games he is hitting .292 with three home runs and seven RBIs.

Rockies Player Leaders

• Hunter Goodman has accumulated 149 hits with a .323 on-base percentage and a .521 slugging percentage, all club-bests for the Rockies. He's batting .278.
• Including all qualified hitters, he is 27th in batting average, while his on-base percentage is 91st and he is 14th in slugging.
• Mickey Moniak is hitting .270 with 20 doubles, eight triples, 24 home runs and 22 walks. He's slugging .518 with an on-base percentage of .306.
• Jordan Beck is batting .260 with 27 doubles, five triples, 16 home runs and 43 walks.
• Tyler Freeman is batting .281 with 20 doubles, two triples, two home runs and 34 walks.

Giants vs Rockies Head to Head

• 9/27/2025: 4-3 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 9/26/2025: 6-3 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 9/3/2025: 10-8 SF (Favorite: Giants, Spread: -1.5, Total: 11.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/2/2025: 7-4 SF (Favorite: Giants, Spread: -1.5, Total: 10.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 9/1/2025: 8-2 SF (Favorite: Giants, Spread: -1.5, Total: 11.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/12/2025: 8-7 COL (Favorite: Giants, Spread: -1.5, Total: 11, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/11/2025: 10-7 SF (Favorite: Giants, Spread: -1.5, Total: 10.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/10/2025: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 11, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 5/4/2025: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -390, Underdog Moneyline: +310)
• 5/3/2025: 6-3 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)

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