Giants vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 3:13 p.m.

The San Francisco Giants are among the MLB teams busy on Wednesday, up against the Arizona Diamondbacks.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Giants vs Diamondbacks Game Info

• San Francisco Giants (74-71) vs. Arizona Diamondbacks (72-74)
• Date: Wednesday, September 10, 2025
• Time: 3:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and ARID

Giants vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-142) | ARI: (+120)
• Spread: SF: -1.5 (+152) | ARI: +1.5 (-184)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Giants vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Carson Seymour (Giants) - 1-2, 4.25 ERA vs Eduardo Rodríguez (Diamondbacks) - 7-8, 5.22 ERA

This contest's pitching matchup is set, as the Giants will send Carson Seymour (1-2) to the mound, while Eduardo Rodriguez (7-8) will get the nod for the Diamondbacks. Seymour has a record of 1-1-0 ATS in two starts with a spread this season. This will be Seymour's first game as the moneyline favorite this season. The Diamondbacks have gone 9-15-0 ATS in Rodríguez's 24 starts with a set spread. The Diamondbacks have been the moneyline underdog in 10 of Rodríguez's starts this season, and they went 5-5 in those matchups.

Giants vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (56.4%)

Giants vs Diamondbacks Moneyline

• The Giants vs Diamondbacks moneyline has San Francisco as a -142 favorite, while Arizona is a +120 underdog on the road.

Giants vs Diamondbacks Spread

• The Diamondbacks are +1.5 on the spread (-184 to cover), and San Francisco is +152 to cover the runline.

Giants vs Diamondbacks Over/Under

• A combined run total of 7.5 has been set for Giants-Diamondbacks on Sept. 10, with the over at -105 and the under at -115.

Bet on San Francisco Giants vs. Arizona Diamondbacks on FanDuel today!

Giants vs Diamondbacks Betting Trends

• The Giants have come away with 47 wins in the 87 contests they have been listed as the favorites in this season.
• San Francisco has a record of 31-22 when favored by -142 or more this year.
• The Giants' games have gone over the total in 69 of their 144 opportunities.
• The Giants have an against the spread mark of 68-76-0 in 144 games with a line this season.
• The Diamondbacks have won 47.5% of the games this season they were the moneyline underdog (28-31).
• Arizona is 14-8 (winning 63.6% of its games) when playing as a moneyline underdog of +120 or longer.
• The Diamondbacks have played in 142 games with a set over/under, and have combined with opponents to go over the total 71 times (71-65-6).
• The Diamondbacks have covered 48.6% of their games this season, going 69-73-0 ATS.

Giants Player Leaders

• Rafael Devers leads San Francisco with 141 hits and an OBP of .378 this season. He has a .259 batting average and a slugging percentage of .485.
• Among qualified hitters in baseball, his batting average ranks 77th, his on-base percentage ranks ninth, and he is 26th in slugging.
• Jung Hoo Lee is batting .271 with 30 doubles, 11 triples, eight home runs and 44 walks. He's slugging .419 with an on-base percentage of .332.
• He ranks 39th in batting average, 67th in on-base percentage and 81st in slugging among qualified hitters.
• Lee brings a two-game streak with at least one hit into this contest. During his last five outings he is batting .500 with a triple, a home run and three RBIs.
• Willy Adames has collected 122 base hits, an OBP of .318 and a slugging percentage of .432 this season.
• Adames has logged a hit or more in two straight games. In his last five games he is hitting .222 with a double, two home runs, two walks and five RBIs.
• Heliot Ramos leads San Francisco in slugging percentage (.403) thanks to 41 extra-base hits.

Diamondbacks Player Leaders

• Geraldo Perdomo has put up a slugging percentage of .443, a team-high for the Diamondbacks. He's batting .282 with an on-base percentage of .381.
• Including all the qualifying hitters in the big leagues, he ranks 21st in batting average, seventh in on-base percentage and 66th in slugging percentage.
• Corbin Carroll leads his team with 131 hits. He has a batting average of .255 while slugging .550 with an on-base percentage of .332.
• Including all qualified hitters, his batting average puts him 82nd, his on-base percentage is 67th, and he is sixth in slugging.
• Ketel Marte has racked up a team-best .384 on-base percentage.
• Gabriel Moreno is hitting .283 with 11 doubles, a triple, eight home runs and 18 walks.

Giants vs Diamondbacks Head to Head

• 9/9/2025: 5-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2025: 11-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/3/2025: 7-2 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/2/2025: 6-5 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/1/2025: 8-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/30/2025: 4-2 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/14/2025: 8-7 ARI (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/13/2025: 10-6 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/12/2025: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/25/2024: 8-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -250, Underdog Moneyline: +205)

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