Giants vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 5:13 a.m.

The Wednesday schedule in MLB includes a matchup between the San Francisco Giants and the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Giants vs Cardinals Game Info

• San Francisco Giants (77-81) vs. St. Louis Cardinals (78-80)
• Date: Wednesday, September 24, 2025
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and FDSMW

Giants vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-130) | STL: (+110)
• Spread: SF: -1.5 (+164) | STL: +1.5 (-200)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Giants vs Cardinals Probable Starting Pitchers

Probable Pitchers: JT Brubaker (Giants) - 0-0, 3.65 ERA vs Sonny Gray (Cardinals) - 14-8, 4.33 ERA

The Giants will give the ball to JT Brubaker and the Cardinals will counter with Sonny Gray (14-8, 4.33 ERA). Brubaker did not pitch as the moneyline favorite in any games last season. The Cardinals have a 15-14-0 record against the spread in Gray's starts. The Cardinals have been the underdog on the moneyline in 10 of Gray's starts this season, and they went 6-4 in those games.

Giants vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.2%)

Giants vs Cardinals Moneyline

• St. Louis is the underdog, +110 on the moneyline, while San Francisco is a -130 favorite at home.

Giants vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-200 to cover), and San Francisco is +164 to cover the runline.

Giants vs Cardinals Over/Under

• The Giants-Cardinals contest on Sept. 24 has been given an over/under of 7.5 runs. The over is set at -110 and the under at -110.

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Giants vs Cardinals Betting Trends

• The Giants have won in 47, or 51.6%, of the 91 contests they have been named as odds-on favorites in this year.
• This season San Francisco has come away with a win 38 times in 68 chances when named as a favorite of at least -130 on the moneyline.
• The Giants and their opponents have gone over the total this season in 76 of their 157 opportunities.
• The Giants have posted a record of 73-84-0 against the spread this season.
• The Cardinals have a 43-44 record in games they were listed as the moneyline underdog (winning 49.4% of those games).
• St. Louis has a record of 22-33 in games it has played as a moneyline underdog with odds of +110 or longer (40%).
• The Cardinals have played in 152 games with a set over/under, and have combined with their opponents to go over the total 78 times (78-69-5).
• The Cardinals have a 78-74-0 record against the spread this season.

Giants Player Leaders

• Rafael Devers leads San Francisco with 149 hits and an OBP of .370 this season. He has a .251 batting average and a slugging percentage of .470.
• Among the qualifying batters in the majors, his batting average ranks 89th, his on-base percentage ranks ninth, and he is 40th in slugging.
• Devers will look for his fifth straight game with a hit in this contest. In his last five games he is hitting .200 with two home runs, three walks and two RBIs.
• Jung Hoo Lee is batting .261 with 30 doubles, 11 triples, eight home runs and 47 walks, while slugging .400 with an on-base percentage of .324.
• His batting average is 59th among qualified players, his on-base percentage 82nd, and his slugging percentage 100th.
• Willy Adames has collected 130 base hits, an OBP of .319 and a slugging percentage of .417 this season.
• Heliot Ramos has an OPS of .732, fueled by an OBP of .331 and a team-best slugging percentage of .401 this season.
• Ramos brings a two-game hitting streak into this game. During his last five outings he is hitting .292 with three home runs and five RBIs.

Cardinals Player Leaders

• Alec Burleson has racked up a team-best slugging percentage (.464) while leading the Cardinals in hits (143). He's batting .294 and with an on-base percentage of .346.
• Including all qualifying hitters in MLB, his batting average places him 10th, his on-base percentage ranks 44th, and he is 43rd in slugging.
• Burleson hopes to build on an eight-game hitting streak in this matchup. In his last 10 outings he is hitting .410 with three doubles, a home run, three walks and six RBIs.
• Brendan Donovan's .354 OBP leads his team. He has a batting average of .287 while slugging .421.
• Including all qualifying hitters, he is 18th in batting average, 32nd in on-base percentage and 79th in slugging percentage.
• Ivan Herrera has 13 doubles, 19 home runs and 42 walks while hitting .283.
• Lars Nootbaar is hitting .238 with 24 doubles, a triple, 13 home runs and 60 walks.

Giants vs Cardinals Head to Head

• 9/23/2025: 9-8 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/22/2025: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/7/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 3-2 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 6-1 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/28/2024: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2024: 6-3 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/23/2024: 5-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/22/2024: 9-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)

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