Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 9:12 p.m.

The Houston Astros are among the MLB squads in action on Wednesday, versus the Athletics.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Athletics Game Info

• Houston Astros (84-73) vs. Athletics (74-83)
• Date: Wednesday, September 24, 2025
• Time: 10:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-132) | OAK: (+112)
• Spread: HOU: -1.5 (+122) | OAK: +1.5 (-146)
• Total: 9.5 -- Over: (-100) | Under: (-122)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 12-8, 2.30 ERA vs Luis Severino (Athletics) - 7-11, 4.72 ERA

The probable starters are Hunter Brown (12-8) for the Astros and Luis Severino (7-11) for the Athletics. When Brown starts, his team is 17-13-0 against the spread this season. Brown's team is 13-9 this season when he starts and they are the moneyline favorite. The Athletics have gone 12-15-0 ATS in Severino's 27 starts that had a set spread. The Athletics have a 9-13 record in Severino's 22 starts this season when they were the moneyline underdog.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (57.2%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -132 favorite, while the Athletics are a +112 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are +122 to cover, while the Athletics are -146 to cover.

Astros vs Athletics Over/Under

• An over/under of 9.5 has been set for Astros-Athletics on Sept. 24, with the over being -100 and the under -122.

Bet on Houston Astros vs. Athletics on FanDuel today!

Astros vs Athletics Betting Trends

• The Astros have been victorious in 50, or 53.2%, of the 94 contests they have been chosen as favorites in this season.
• This year, the Astros have won 32 of 57 games when listed as at least -132 or better on the moneyline.
• The Astros and their opponents have hit the over in 71 of their 156 games with a total this season.
• The Astros are 77-79-0 against the spread in their 156 games that had a posted line this season.
• The Athletics have a 53-62 record in games they were listed as the moneyline underdog (winning 46.1% of those games).
• When playing as a moneyline underdog with odds of +112 or longer, the Athletics have gone 32-46 (41%).
• The Athletics have played in 156 games with an over/under set, and have combined with their opponents to go over the total 75 times (75-74-7).
• The Athletics have gone 83-73-0 ATS this season.

Astros Player Leaders

• Jose Altuve leads Houston with a slugging percentage of .441, fueled by 50 extra-base hits. He has a .263 batting average and an on-base percentage of .325.
• He is 53rd in batting average, 79th in on-base percentage, and 64th in slugging among qualified hitters in MLB.
• Jeremy Pena leads Houston with 150 hits and an OBP of .363 this season. He's batting .304 and slugging .477.
• Among qualified batters, he ranks fifth in batting average, 16th in on-base percentage and 32nd in slugging percentage.
• Yainer Diaz is batting .256 with a .412 slugging percentage and 68 RBI this year.
• Carlos Correa has 13 home runs, 50 RBI and a batting average of .272 this season.

Athletics Player Leaders

• Brent Rooker has put up a slugging percentage of .485, a team-high for the Athletics. He's batting .264 with an on-base percentage of .335.
• Including all qualified hitters in MLB, his batting average puts him 51st, his on-base percentage ranks 60th, and he is 24th in slugging.
• Tyler Soderstrom is hitting .278 with 32 doubles, a triple, 24 home runs and 53 walks. He's slugging .473 with an on-base percentage of .348.
• Including all qualifying hitters, he is 26th in batting average, 43rd in on-base percentage and 39th in slugging percentage.
• Jacob Wilson has an on-base percentage of .362, a team-high for the Athletics.
• Nick Kurtz has 26 doubles, two triples, 33 home runs and 60 walks while hitting .291.

Astros vs Athletics Head to Head

• 9/23/2025: 5-1 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/27/2025: 7-1 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/26/2025: 5-1 OAK (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/25/2025: 15-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/24/2025: 5-2 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/19/2025: 6-4 OAK (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/18/2025: 11-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/17/2025: 13-3 HOU (Favorite: Astros, Spread: -1.5, Total: 11, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/16/2025: 3-1 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2025: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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