Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 5:12 a.m.

The MLB schedule on Wednesday includes the Houston Astros taking on the Athletics.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Athletics Game Info

• Houston Astros (84-73) vs. Athletics (74-83)
• Date: Wednesday, September 24, 2025
• Time: 10:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-146) | OAK: (+124)
• Spread: HOU: -1.5 (+112) | OAK: +1.5 (-134)
• Total: 9 -- Over: (-110) | Under: (-110)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 12-8, 2.30 ERA vs Luis Severino (Athletics) - 7-11, 4.72 ERA

This contest's pitching matchup is set, as the Astros will send Hunter Brown (12-8) to the mound, while Luis Severino (7-11) will answer the bell for the Athletics. Brown and his team have a record of 17-13-0 against the spread when he starts. Brown's team has won 59.1% of his starts when they are favored on the moneyline (13-9). The Athletics have a 12-15-0 record against the spread in Severino's starts. The Athletics have a 9-13 record in Severino's 22 starts this season when they were the underdog on the moneyline.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.9%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -146 favorite, while the Athletics are a +124 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are +112 to cover, while the Athletics are -134 to cover.

Astros vs Athletics Over/Under

• A combined run total of 9 has been set for Astros-Athletics on Sept. 24, with the over at -110 and the under at -110.

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Astros vs Athletics Betting Trends

• The Astros have been chosen as favorites in 94 games this year and have walked away with the win 50 times (53.2%) in those games.
• This year, the Astros have won 20 of 36 games when listed as at least -146 or better on the moneyline.
• The Astros and their opponents have hit the over in 71 of their 156 games with a total this season.
• The Astros are 77-79-0 against the spread in their 156 games that had a posted line this season.
• The Athletics have won 46.1% of the games this season they were the moneyline underdog (53-62).
• The Athletics have a record of 23-36 in games they have played as a moneyline underdog with odds of +124 or longer (39%).
• The Athletics have combined with their opponents to hit the over on the total 75 times this season for a 75-74-7 record against the over/under.
• The Athletics have an 83-73-0 record against the spread this season (covering 53.2% of the time).

Astros Player Leaders

• Jose Altuve has an OPS of .766, fueled by an OBP of .325 and a team-best slugging percentage of .441 this season. He has a .263 batting average.
• Among qualifying hitters in the majors, he ranks 53rd in batting average, 79th in on-base percentage, and 64th in slugging.
• Jeremy Pena leads the Astros in OBP (.363) and total hits (150) this season. He's batting .304 while slugging .477.
• Among qualifying batters, he ranks fifth in batting average, 16th in on-base percentage and 32nd in slugging percentage.
• Yainer Diaz has collected 134 base hits, an OBP of .284 and a slugging percentage of .412 this season.
• Carlos Correa is batting .272 with a .328 OBP and 50 RBI for Houston this season.

Athletics Player Leaders

• Brent Rooker has accumulated a slugging percentage of .485, a team-high for the Athletics. He's batting .264 with an on-base percentage of .335.
• Including all qualifying hitters, he ranks 51st in batting average, while his on-base percentage is 61st and he is 24th in slugging.
• Tyler Soderstrom is batting .278 with 32 doubles, a triple, 24 home runs and 53 walks. He's slugging .473 with an on-base percentage of .348.
• Including all qualifying hitters, he is 26th in batting average, 43rd in on-base percentage and 38th in slugging percentage.
• Jacob Wilson has a team-high .362 on-base percentage.
• Nick Kurtz has 26 doubles, two triples, 33 home runs and 60 walks while batting .291.

Astros vs Athletics Head to Head

• 9/23/2025: 5-1 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/27/2025: 7-1 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/26/2025: 5-1 OAK (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/25/2025: 15-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/24/2025: 5-2 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/19/2025: 6-4 OAK (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/18/2025: 11-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/17/2025: 13-3 HOU (Favorite: Astros, Spread: -1.5, Total: 11, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/16/2025: 3-1 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2025: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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