Giants vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 9:12 p.m.

The San Francisco Giants will take on the St. Louis Cardinals in MLB action on Tuesday.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Giants vs Cardinals Game Info

• San Francisco Giants (77-80) vs. St. Louis Cardinals (77-80)
• Date: Tuesday, September 23, 2025
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and FDSMW

Giants vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-200) | STL: (+168)
• Spread: SF: -1.5 (+106) | STL: +1.5 (-128)
• Total: 7.5 -- Over: (-114) | Under: (-106)

Giants vs Cardinals Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 14-11, 3.27 ERA vs Andre Pallante (Cardinals) - 6-15, 5.29 ERA

The Giants will call on Logan Webb (14-11) against the Cardinals and Andre Pallante (6-15). Webb and his team have a record of 15-17-0 against the spread when he starts. Webb's team is 14-14 this season when he starts and they are the moneyline favorite. When Pallante starts, the Cardinals have gone 14-16-0 against the spread. The Cardinals are 7-13 in Pallante's 20 starts this season that they were the moneyline underdog.

Giants vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (61.3%)

Giants vs Cardinals Moneyline

• The Giants vs Cardinals moneyline has San Francisco as a -200 favorite, while St. Louis is a +168 underdog on the road.

Giants vs Cardinals Spread

• The Giants are 1.5-run home favorites on the runline against the Cardinals. The Giants are +106 to cover, and the Cardinals are -128.

Giants vs Cardinals Over/Under

• An over/under of 7.5 has been set for Giants-Cardinals on Sept. 23, with the over being -114 and the under -106.

Bet on San Francisco Giants vs. St. Louis Cardinals on FanDuel today!

Giants vs Cardinals Betting Trends

• The Giants have been favorites in 90 games this season and have come away with the win 47 times (52.2%) in those contests.
• This year San Francisco has won five of 10 games when listed as at least -200 on the moneyline.
• The Giants' games have gone over the total in 75 of their 156 opportunities.
• The Giants are 73-83-0 against the spread in their 156 games with a line set by sportsbooks this season.
• The Cardinals have won 48.8% of the games this season they were the moneyline underdog (42-44).
• When playing as a moneyline underdog with odds of +168 or longer, St. Louis has a record of 1-5 (16.7%).
• In the 151 games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 77 times (77-69-5).
• The Cardinals have a 77-74-0 record against the spread this season (covering 51% of the time).

Giants Player Leaders

• Rafael Devers has 148 hits and an OBP of .371, both of which are tops among San Francisco hitters this season. He has a .252 batting average and a slugging percentage of .473.
• Among all qualifying hitters in the majors, his batting average ranks 88th, his on-base percentage ranks ninth, and he is 37th in slugging.
• Devers hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .167 with two home runs, four walks and three RBIs.
• Jung Hoo Lee has 30 doubles, 11 triples, eight home runs and 47 walks. He's batting .261 and slugging .401 with an on-base percentage of .324.
• He is 60th in batting average, 82nd in on-base percentage and 98th in slugging in MLB.
• Willy Adames is batting .224 with a .415 slugging percentage and 83 RBI this year.
• Heliot Ramos leads San Francisco with a slugging percentage of .396, fueled by 44 extra-base hits.

Cardinals Player Leaders

• Alec Burleson has accumulated 141 hits with a .465 slugging percentage, both team-high numbers for the Cardinals. He's batting .293 and with an on-base percentage of .345.
• Including all the qualified players in MLB, he is 10th in batting average, 46th in on-base percentage and 43rd in slugging percentage.
• Burleson takes a seven-game hitting streak into this game. During his last 10 games he is hitting .421 with three doubles, a triple, a home run, four walks and five RBIs.
• Brendan Donovan has a .349 OBP to pace his team. He has a batting average of .282 while slugging .408.
• Including all qualifying players, he ranks 21st in batting average, 39th in on-base percentage and 90th in slugging percentage.
• Ivan Herrera has 13 doubles, 18 home runs and 41 walks while hitting .281.
• Lars Nootbaar is hitting .236 with 23 doubles, a triple, 13 home runs and 60 walks.

Giants vs Cardinals Head to Head

• 9/22/2025: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/7/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 3-2 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 6-1 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/28/2024: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2024: 6-3 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/23/2024: 5-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/22/2024: 9-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/20/2024: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!