Florida vs South Florida Prediction, Odds, Picks, Best Bets for Week 2 2025

The Florida Gators will face the South Florida Bulls in college football action on Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information about today's NCAA football betting odds.

Florida vs South Florida Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Florida: (-1000) | South Florida: (+640)
• Spread: Florida: -17.5 (-118) | South Florida: +17.5 (-104)
• Total: 56.5 -- Over: (-110) | Under: (-110)

Florida vs South Florida Betting Trends

• Florida has covered the spread in every game this year.
• Florida has yet to lose ATS (1-0) as a 17.5-point favorite or greater this year.
• South Florida has posted one win against the spread this year.
• South Florida and its opponent have yet to hit the over this year.

Florida vs South Florida Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Gators win (93.4%)

Florida vs South Florida Point Spread

South Florida is an underdog by 17.5 points against Florida. South Florida is -104 to cover the spread, and Florida is -118.

Florida vs South Florida Over/Under

A combined point total of 56.5 has been set for Florida-South Florida on Sept. 6, with the over at -110 and the under at -110.

Florida vs South Florida Moneyline

Florida is a -1000 favorite on the moneyline, while South Florida is a +640 underdog.

Florida vs. South Florida Points Insights

• The average implied total for the Gators last season was 31.9 points, 5.1 fewer points than their implied total of 37 points in Saturday's game.
• The Bulls' average implied point total last season (34.3 points) is 14.3 points higher than their implied total in this matchup (20 points).

Florida vs. South Florida Game Info

• Game day: Saturday, September 6, 2025
• Game time: 4:15 p.m. ET
• TV channel: SEC Network
• Location: Gainesville, Florida
• Stadium: Ben Hill Griffin Stadium

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Check out even more in-depth Florida vs. South Florida analysis on FanDuel Research.