Brewers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 11:12 p.m.

On Wednesday in MLB, the Milwaukee Brewers are playing the San Diego Padres.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Brewers vs Padres Game Info

• Milwaukee Brewers (95-62) vs. San Diego Padres (86-71)
• Date: Wednesday, September 24, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: MLB Network, SDPA, and FDSWI

Brewers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-118) | SD: (-100)
• Spread: MIL: -1.5 (+136) | SD: +1.5 (-164)
• Total: 8 -- Over: (-110) | Under: (-110)

Brewers vs Padres Probable Starting Pitchers

Probable Pitchers: Quinn Priester (Brewers) - 13-2, 3.25 ERA vs Dylan Cease (Padres) - 8-12, 4.64 ERA

The Brewers will give the nod to Quinn Priester (13-2, 3.25 ERA), who is eyeing win No. 14 on the season, and the Padres will counter with Dylan Cease (8-12, 4.64 ERA). When Priester starts, his team is 15-8-0 against the spread this season. Priester's team has won 83.3% of his starts when they are favored on the moneyline (10-2). The Padres have gone 14-17-0 ATS in Cease's 31 starts that had a set spread. The Padres have been the underdog on the moneyline in eight of Cease's starts this season, and they went 3-5 in those games.

Brewers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (53.4%)

Brewers vs Padres Moneyline

• Milwaukee is the favorite, -118 on the moneyline, while San Diego is a -100 underdog despite being at home.

Brewers vs Padres Spread

• The Brewers are at the Padres and are favored by 1.5 runs (+136 to cover) on the runline. San Diego is -164 to cover.

Brewers vs Padres Over/Under

• An over/under of 8 has been set for Brewers-Padres on Sept. 24, with the over being -110 and the under -110.

Bet on Milwaukee Brewers vs. San Diego Padres on FanDuel today!

Brewers vs Padres Betting Trends

• The Brewers have been favorites in 92 games this season and have come away with the win 59 times (64.1%) in those contests.
• Milwaukee has a record of 54-27 when favored by -118 or more this year.
• The Brewers and their opponents have hit the over in 78 of their 154 games with a total set by oddsmakers this season.
• The Brewers are 85-69-0 against the spread in their 154 games that had a posted line this season.
• The Padres are 32-34 in games they were listed as the moneyline underdog (winning 48.5% of those games).
• San Diego has gone 27-30 when it has played as a moneyline underdog with odds of -100 or longer (47.4%).
• In the 155 games bookmakers have set an over/under for the Padres, they have combined with opponents to go over the total 68 times (68-84-3).
• The Padres have gone 83-72-0 against the spread this season.

Brewers Player Leaders

• William Contreras has 147 hits this season and a team-best OBP of .359. He has a .263 batting average and a slugging percentage of .404.
• Among all qualifying hitters in the majors, his batting average ranks 57th, his on-base percentage ranks 21st, and he is 93rd in slugging.
• Christian Yelich is hitting .266 with 20 doubles, 29 home runs and 63 walks, while slugging .460 with an on-base percentage of .346.
• Among qualifying batters, he is 46th in batting average, 44th in on-base percentage and 48th in slugging percentage.
• Brice Turang leads Milwaukee in slugging percentage (.434) powered by 46 extra-base hits.
• Sal Frelick is batting .292 with a .356 OBP and 63 RBI for Milwaukee this season.

Padres Player Leaders

• Fernando Tatis Jr. is batting .267 with 27 doubles, two triples, 23 home runs and 88 walks. He's slugging .438 with an on-base percentage of .367.
• Including all the qualified hitters in the majors, his batting average is 43rd, his on-base percentage ranks 13th, and he is 66th in slugging.
• Tatis hopes to build on a five-game hitting streak in this matchup. In his last five games he is batting .381 with a home run, two walks and an RBI.
• Manny Machado paces his team with 166 hits. He has a batting average of .274 while slugging .458 with an on-base percentage of .334.
• His batting average is 32nd among all qualified players, his on-base percentage ranks 63rd, and he is 49th in slugging.
• Luis Arraez has put up a slugging percentage of .382, a team-best for the Padres.
• Ramon Laureano is batting .282 with 26 doubles, two triples, 24 home runs and 35 walks.

Brewers vs Padres Head to Head

• 9/22/2025: 5-4 SD (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/8/2025: 1-0 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/7/2025: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/6/2025: 2-0 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/23/2024: 6-2 MIL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/22/2024: 6-4 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/21/2024: 9-5 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/20/2024: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/17/2024: 1-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/16/2024: 6-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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