Brewers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 4:15 p.m.

The Milwaukee Brewers are among the MLB squads busy on Wednesday, versus the San Diego Padres.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Brewers vs Padres Game Info

• Milwaukee Brewers (95-63) vs. San Diego Padres (87-71)
• Date: Wednesday, September 24, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: MLB Network, SDPA, and FDSWI

Brewers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-118) | SD: (-100)
• Spread: MIL: -1.5 (+136) | SD: +1.5 (-164)
• Total: 8 -- Over: (-110) | Under: (-110)

Brewers vs Padres Probable Starting Pitchers

Probable Pitchers: Chad Patrick (Brewers) - 3-8, 3.66 ERA vs Dylan Cease (Padres) - 8-12, 4.64 ERA

The Brewers will give the ball to Chad Patrick (3-8, 3.66 ERA), who is eyeing win No. 4 on the season, and the Padres will counter with Dylan Cease (8-12, 4.64 ERA). Patrick and his team have a record of 6-14-0 against the spread when he starts. Patrick's team has a record of 4-7 this season when he starts and they are the favorite on the moneyline. The Padres are 14-17-0 against the spread when Cease starts. The Padres are 3-5 in Cease's eight starts this season that they were the underdog on the moneyline.

Brewers vs Padres Moneyline

• San Diego is the underdog, -100 on the moneyline, while Milwaukee is a -118 favorite despite being on the road.

Brewers vs Padres Spread

• The Padres are +1.5 on the run line against the Brewers. The Padres are -164 to cover, and the Brewers are +136.

Brewers vs Padres Over/Under

• An over/under of 8 has been set for Brewers-Padres on Sept. 24, with the over being -110 and the under -110.

Bet on Milwaukee Brewers vs. San Diego Padres on FanDuel today!

Brewers vs Padres Betting Trends

• The Brewers have won in 59, or 63.4%, of the 93 contests they have been named as odds-on favorites in this year.
• This season Milwaukee has come away with a win 54 times in 82 chances when named as a favorite of at least -118 on the moneyline.
• The Brewers' games have gone over the total in 78 of their 155 opportunities.
• The Brewers are 85-70-0 against the spread in their 155 games with a line set by sportsbooks this season.
• The Padres have compiled a 33-34 record in games they were listed as the moneyline underdog (winning 49.3% of those games).
• When it has played as a moneyline underdog with odds of -100 or longer, San Diego has a 27-30 record (winning 47.4% of its games).
• The Padres have played in 156 games with an over/under set, and have combined with opponents to go over the total 68 times (68-85-3).
• The Padres have put together an 84-72-0 record ATS this season (covering 53.8% of the time).

Brewers Player Leaders

• William Contreras leads Milwaukee with an OBP of .357 this season while batting .262 with 84 walks and 89 runs scored. He has a slugging percentage of .402.
• Among qualified hitters in MLB, he ranks 57th in batting average, 25th in on-base percentage, and 97th in slugging.
• Christian Yelich is hitting .266 with 20 doubles, 29 home runs and 63 walks. He's slugging .459 with an on-base percentage of .346.
• Among qualified hitters, his batting average ranks him 46th, his on-base percentage 44th, and his slugging percentage 50th.
• Yelich brings a two-game streak with at least one hit into this one. In his last five games he is batting .222 with three walks and two RBIs.
• Brice Turang has hit 18 homers with a team-high .432 SLG this season.
• Sal Frelick has 12 home runs, 63 RBI and a batting average of .291 this season.

Padres Player Leaders

• Fernando Tatis Jr. has 27 doubles, two triples, 23 home runs and 88 walks while batting .267. He's slugging .438 with an on-base percentage of .367.
• He is 44th in batting average, 11th in on-base percentage and 67th in slugging percentage among all qualified hitters in the majors.
• Tatis heads into this game on a five-game hitting streak. In his last five games he is batting .381 with a home run, two walks and an RBI.
• Manny Machado's 166 hits lead his team. He has a batting average of .274 while slugging .458 with an on-base percentage of .334.
• He is currently 32nd in batting average, 63rd in on-base percentage and 52nd in slugging percentage among all qualifying hitters.
• Luis Arraez has put up a slugging percentage of .388, a team-high for the Padres.
• Ramon Laureano is batting .282 with 26 doubles, two triples, 24 home runs and 35 walks.

Brewers vs Padres Head to Head

• 9/23/2025: 7-0 SD (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/22/2025: 5-4 SD (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/8/2025: 1-0 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/7/2025: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/6/2025: 2-0 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/23/2024: 6-2 MIL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/22/2024: 6-4 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/21/2024: 9-5 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/20/2024: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/17/2024: 1-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)

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