Dodgers vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 9:12 p.m.

The Los Angeles Dodgers are among the MLB squads busy on Tuesday, up against the Arizona Diamondbacks.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Diamondbacks Game Info

• Los Angeles Dodgers (88-68) vs. Arizona Diamondbacks (79-77)
• Date: Tuesday, September 23, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and SportsNet LA

Dodgers vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-162) | ARI: (+136)
• Spread: LAD: -1.5 (-102) | ARI: +1.5 (-118)
• Total: 9 -- Over: (-106) | Under: (-114)

Dodgers vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Shohei Ohtani (Dodgers) - 1-1, 3.29 ERA vs Brandon Pfaadt (Diamondbacks) - 13-8, 5.02 ERA

This contest's pitching matchup is set, as the Dodgers will send Shohei Ohtani (1-1) to the mound, while Brandon Pfaadt (13-8) will get the nod for the Diamondbacks. Ohtani's team is 4-9-0 against the spread in his starts this season. Ohtani's team has won 38.5% of his starts when they are favored on the moneyline (5-8). The Diamondbacks have gone 19-12-0 against the spread when Pfaadt starts. The Diamondbacks have a 7-8 record in Pfaadt's 15 starts this season when they were the underdog on the moneyline.

Dodgers vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (58.5%)

Dodgers vs Diamondbacks Moneyline

• Looking at the moneyline for Dodgers-Diamondbacks, Los Angeles is the favorite at -162, and Arizona is +136 playing at home.

Dodgers vs Diamondbacks Spread

• The Diamondbacks are at +1.5 on the runline against the Dodgers. The Diamondbacks are -118 to cover the spread, and the Dodgers are -102.

Dodgers vs Diamondbacks Over/Under

• The Dodgers-Diamondbacks game on Sept. 23 has been given an over/under of 9 runs. The over is set at -106 and the under at -114.

Bet on Los Angeles Dodgers vs. Arizona Diamondbacks on FanDuel today!

Dodgers vs Diamondbacks Betting Trends

• The Dodgers have been chosen as favorites in 137 games this year and have walked away with the win 78 times (56.9%) in those games.
• This season Los Angeles has been victorious 52 times in 88 chances when named as a favorite of at least -162 on the moneyline.
• The Dodgers and their opponents have gone over in 74 of their 154 games with a total set by sportsbooks this season.
• The Dodgers are 66-88-0 against the spread in their 154 games that had a posted line this season.
• The Diamondbacks have won 32 of the 64 games they were listed as the moneyline underdog this season (50%).
• Arizona has a 5-6 record (winning 45.5% of its games) when it has played as a moneyline underdog of +136 or longer.
• The Diamondbacks have had an over/under set by oddsmakers 152 times, and have combined with opponents to go over the total in 76 of those games (76-69-7).
• The Diamondbacks have gone 76-76-0 ATS this season.

Dodgers Player Leaders

• Ohtani leads Los Angeles with 167 hits and an OBP of .395, plus a team-best slugging percentage of .620. He's batting .283.
• He is 20th in batting average, third in on-base percentage, and second in slugging among all qualifying batters in MLB.
• Ohtani has hit safely in nine games in a row. During his last 10 outings he is hitting .325 with three doubles, five home runs, eight walks and seven RBIs.
• Mookie Betts is batting .258 with 23 doubles, two triples, 20 home runs and 60 walks, while slugging .411 with an on-base percentage of .328.
• Among all qualified, he is 72nd in batting average, 75th in on-base percentage and 87th in slugging percentage.
• Freddie Freeman has 158 hits this season and has a slash line of .292/.362/.488.
• Freeman brings a two-game hitting streak into this game. In his last five games he is batting .250 with a home run and three RBIs.
• Andy Pages has 25 home runs, 82 RBI and a batting average of .278 this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has a .391 on-base percentage and a .462 slugging percentage, both team-best numbers for the Diamondbacks. He's batting .290.
• Including all the qualified hitters in MLB, he ranks 15th in batting average, fifth in on-base percentage and 46th in slugging percentage.
• Perdomo enters this game on an 11-game hitting streak. In his last 10 outings he is batting .405 with four doubles, a triple, two home runs, seven walks and six RBIs.
• Corbin Carroll leads his team with 143 hits. He has a batting average of .260 while slugging .546 with an on-base percentage of .340.
• Including all qualified hitters, his batting average places him 62nd, his on-base percentage ranks 53rd, and he is sixth in slugging.
• Ketel Marte is batting .280 with 26 doubles, 26 home runs and 63 walks.
• Gabriel Moreno has 12 doubles, a triple, nine home runs and 25 walks while hitting .291.

Dodgers vs Diamondbacks Head to Head

• 8/31/2025: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 8/30/2025: 6-1 ARI (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 8/29/2025: 3-0 ARI (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 5/21/2025: 3-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/20/2025: 4-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 5/19/2025: 9-5 ARI (Favorite: Dodgers, Spread: -1.5, Total: 10.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/11/2025: 8-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/10/2025: 3-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/9/2025: 14-11 LAD (Favorite: Diamondbacks, Spread: -1.5, Total: 10.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/8/2025: 5-3 ARI (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!