Diamondbacks vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 3:12 p.m.

In MLB action on Wednesday, the Arizona Diamondbacks take on the San Francisco Giants.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs Giants Game Info

• Arizona Diamondbacks (77-75) vs. San Francisco Giants (75-76)
• Date: Wednesday, September 17, 2025
• Time: 3:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: MLB Network, ARID, and NBCS-BA

Diamondbacks vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-130) | SF: (+110)
• Spread: ARI: -1.5 (+158) | SF: +1.5 (-192)
• Total: 9 -- Over: (-115) | Under: (-105)

Diamondbacks vs Giants Probable Starting Pitchers

Probable Pitchers: Brandon Pfaadt (Diamondbacks) - 13-8, 5.31 ERA vs Justin Verlander (Giants) - 3-10, 3.94 ERA

This contest's pitching matchup is set, as the Diamondbacks will send Brandon Pfaadt (13-8) to the mound, while Justin Verlander (3-10) will answer the bell for the Giants. Pfaadt's team is 19-11-0 against the spread this season in his starts. Pfaadt's team has a record of 8-7 this season when he starts and they are the favorite on the moneyline. The Giants have an 8-18-0 record against the spread in Verlander's starts. The Giants are 4-8 in Verlander's 12 starts this season that they were the moneyline underdog.

Diamondbacks vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (54.5%)

Diamondbacks vs Giants Moneyline

• The Diamondbacks vs Giants moneyline has Arizona as a -130 favorite, while San Francisco is a +110 underdog on the road.

Diamondbacks vs Giants Spread

• The Diamondbacks are favored by 1.5 runs at home versus the Giants. The Diamondbacks are +158 to cover the spread, while the Giants are -192.

Diamondbacks vs Giants Over/Under

• A total of 9 runs has been set for the Diamondbacks-Giants contest on Sept. 17, with the over available at -115 and the under at -105.

Bet on Arizona Diamondbacks vs. San Francisco Giants on FanDuel today!

Diamondbacks vs Giants Betting Trends

• The Diamondbacks have been chosen as favorites in 83 games this year and have walked away with the win 44 times (53%) in those games.
• Arizona has a record of 28-25 in contests when bookmakers favor them by -130 or more on the moneyline.
• The Diamondbacks' games have gone over the total in 74 of their 148 opportunities.
• The Diamondbacks have an against the spread record of 74-74-0 in 148 games with a line this season.
• The Giants have won 45% of the games this season they were the moneyline underdog (27-33).
• San Francisco has gone 16-22 when it has played as a moneyline underdog with odds of +110 or longer (42.1%).
• In the 150 games bookmakers have set an over/under for the Giants, they have combined with opponents to go over the total 72 times (72-70-8).
• The Giants have a 70-80-0 record ATS this season.

Diamondbacks Player Leaders

• Geraldo Perdomo leads Arizona with an OBP of .393, plus a team-best slugging percentage of .463. He's batting .290 on the season.
• Among all qualifying hitters in the majors, his batting average ranks 14th, his on-base percentage ranks sixth, and he is 46th in slugging.
• Perdomo will look for his eighth straight game with a hit in this contest. In his last 10 games he is hitting .333 with two doubles, a triple, two home runs, nine walks and seven RBIs.
• Corbin Carroll leads Arizona with 138 hits. He is batting .258 this season and has 76 extra-base hits. He's also slugging .542 with an on-base percentage of .339.
• His batting average ranks 74th among qualified players, his on-base percentage 53rd, and his slugging percentage seventh.
• Carroll enters this game looking to extend his three-game hit streak. In his last five games he is batting .368 with a double, five walks and three RBIs.
• Ketel Marte has 123 hits this season and has a slash line of .278/.376/.502.
• Gabriel Moreno has been key for Arizona with 70 hits, an OBP of .348 plus a slugging percentage of .457.

Giants Player Leaders

• Rafael Devers has racked up 144 hits with a .374 on-base percentage, leading the Giants in both categories. He's batting .255 and slugging .474.
• Including all the qualified hitters in the big leagues, his batting average places him 82nd, his on-base percentage is ninth, and he is 36th in slugging.
• Jung Hoo Lee has 30 doubles, 11 triples, eight home runs and 46 walks while hitting .262. He's slugging .406 with an on-base percentage of .326.
• He is currently 60th in batting average, 79th in on-base percentage and 94th in slugging percentage among all qualified hitters.
• Willy Adames is hitting .229 with 20 doubles, two triples, 28 home runs and 72 walks.
• Matt Chapman is batting .237 with 20 doubles, two triples, 21 home runs and 66 walks.

Diamondbacks vs Giants Head to Head

• 9/16/2025: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/15/2025: 8-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 5-3 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/9/2025: 5-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2025: 11-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/3/2025: 7-2 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/2/2025: 6-5 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/1/2025: 8-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/30/2025: 4-2 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/14/2025: 8-7 ARI (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)

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