Diamondbacks vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 9:12 p.m.

MLB action on Tuesday includes the Arizona Diamondbacks facing the San Francisco Giants.

We've got you covered, in terms of the most important information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs Giants Game Info

• Arizona Diamondbacks (76-75) vs. San Francisco Giants (75-75)
• Date: Tuesday, September 16, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and NBCS-BA

Diamondbacks vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-130) | SF: (+110)
• Spread: ARI: -1.5 (+158) | SF: +1.5 (-192)
• Total: 9 -- Over: (-115) | Under: (-105)

Diamondbacks vs Giants Probable Starting Pitchers

Probable Pitchers: Eduardo Rodríguez (Diamondbacks) - 8-8, 4.98 ERA vs Tristan Beck (Giants) - 1-0, 4.88 ERA

The Diamondbacks will look to Eduardo Rodriguez (8-8) against the Giants and Tristan Beck (1-0). Rodríguez's team is 10-15-0 against the spread in his starts this season. Rodriguez's team has a record of 7-7 this season when he starts and they are the favorite on the moneyline. Last season Beck pitched in one game with a spread, which his team did not cover. Beck never pitched as a moneyline underdog a season ago.

Diamondbacks vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (60.7%)

Diamondbacks vs Giants Moneyline

• San Francisco is the underdog, +110 on the moneyline, while Arizona is a -130 favorite at home.

Diamondbacks vs Giants Spread

• The Diamondbacks are 1.5-run home favorites on the runline against the Giants. The Diamondbacks are +158 to cover, and the Giants are -192.

Diamondbacks vs Giants Over/Under

• The over/under for Diamondbacks-Giants on Sept. 16 is 9. The over is -115, and the under is -105.

Bet on Arizona Diamondbacks vs. San Francisco Giants on FanDuel today!

Diamondbacks vs Giants Betting Trends

• The Diamondbacks have been chosen as favorites in 82 games this year and have walked away with the win 43 times (52.4%) in those games.
• Arizona has a record of 27-25 in contests when bookmakers favor them by -130 or more on the moneyline.
• Contests with the Diamondbacks have gone over the total set by sportsbooks in 73 of 147 chances this season.
• The Diamondbacks are 74-73-0 against the spread in their 147 games that had a posted line this season.
• The Giants are 27-32 in games they were listed as the moneyline underdog (winning 45.8% of those games).
• San Francisco is 16-22 (winning 42.1% of its games) when it has played as a moneyline underdog of +110 or longer.
• In the 149 games oddsmakers have set an over/under for the Giants, they have combined with opponents to go over the total 71 times (71-70-8).
• The Giants are 69-80-0 against the spread this season.

Diamondbacks Player Leaders

• Geraldo Perdomo leads Arizona OPS (.853) this season. He has a .290 batting average, an on-base percentage of .391, and a slugging percentage of .462.
• Among qualifying batters in baseball, he ranks 15th in batting average, sixth in on-base percentage, and 44th in slugging.
• Perdomo has recorded at least one hit in six straight games. In his last 10 games he is hitting .400 with a double, a triple, three home runs, eight walks and nine RBIs.
• Corbin Carroll leads Arizona in total hits (135) this season while batting .255 with 76 extra-base hits. He's slugging .542 with an on-base percentage of .337.
• His batting average ranks 81st among qualified players, his on-base percentage 55th, and his slugging percentage seventh.
• Carroll has picked up at least one hit in two straight games. In his last five games he is hitting .235 with a double, seven walks and two RBIs.
• Ketel Marte is batting .277 with a .501 slugging percentage and 65 RBI this year.
• Gabriel Moreno has nine home runs, 37 RBI and a batting average of .289 this season.

Giants Player Leaders

• Rafael Devers has racked up 143 hits with a .375 on-base percentage, leading the Giants in both categories. He's batting .255 and slugging .476.
• Including all qualifying hitters, he is 81st in batting average, while his on-base percentage is ninth and he is 33rd in slugging.
• Jung Hoo Lee is hitting .264 with 30 doubles, 11 triples, eight home runs and 46 walks. He's slugging .409 with an on-base percentage of .328.
• He is currently 49th in batting average, 76th in on-base percentage and 88th in slugging percentage among all qualified hitters.
• Willy Adames is hitting .230 with 20 doubles, two triples, 28 home runs and 71 walks.
• Matt Chapman is hitting .239 with 20 doubles, two triples, 21 home runs and 66 walks.

Diamondbacks vs Giants Head to Head

• 9/15/2025: 8-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 5-3 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/9/2025: 5-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2025: 11-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/3/2025: 7-2 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/2/2025: 6-5 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/1/2025: 8-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/30/2025: 4-2 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/14/2025: 8-7 ARI (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/13/2025: 10-6 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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