Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 6:14 p.m.

The Chicago Cubs are among the MLB squads in action on Friday, versus the Cincinnati Reds.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Cubs vs Reds Game Info

• Chicago Cubs (88-65) vs. Cincinnati Reds (77-76)
• Date: Friday, September 19, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: MLB Network, FDSOH, and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-112) | CIN: (-104)
• Spread: CHC: -1.5 (+146) | CIN: +1.5 (-176)
• Total: 8 -- Over: (-118) | Under: (-104)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 9-7, 3.29 ERA vs Nick Lodolo (Reds) - 8-8, 3.30 ERA

The Cubs will give the nod to Shota Imanaga (9-7) versus the Reds and Nick Lodolo (8-8). Imanaga's team is 9-13-0 against the spread in his starts this season. Imanaga's team has a record of 9-6 this season when he starts and they are the favorite on the moneyline. The Reds have gone 13-11-0 against the spread when Lodolo starts. The Reds have been the moneyline underdog in 13 of Lodolo's starts this season, and they went 5-8 in those games.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (54.3%)

Cubs vs Reds Moneyline

• Chicago is the favorite, -112 on the moneyline, while Cincinnati is a -104 underdog despite being at home.

Cubs vs Reds Spread

• The Cubs are favored by 1.5 runs on the road versus the Reds. The Cubs are +146 to cover the spread, while the Reds are -176.

Cubs vs Reds Over/Under

• The over/under for the Cubs versus Reds game on Sept. 19 has been set at 8, with -118 odds on the over and -104 odds on the under.

Bet on Chicago Cubs vs. Cincinnati Reds on FanDuel today!

Cubs vs Reds Betting Trends

• The Cubs have been victorious in 66, or 64.1%, of the 103 contests they have been chosen as favorites in this season.
• This season Chicago has been victorious 66 times in 103 chances when named as a favorite of at least -112 on the moneyline.
• The Cubs' games have gone over the total in 68 of their 149 opportunities.
• The Cubs are 71-78-0 against the spread in their 149 games with a line set by sportsbooks this season.
• The Reds have been the underdog on the moneyline 81 total times this season. They've finished 39-42 in those games.
• In games it has played as a moneyline underdog with odds of -104 or longer, Cincinnati has a 34-40 record (winning 45.9% of its games).
• In the 146 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 57 times (57-81-8).
• The Reds have gone 75-71-0 against the spread this season.

Cubs Player Leaders

• Nico Hoerner leads Chicago with a slugging percentage of .399, fueled by 39 extra-base hits. He has a .301 batting average and an on-base percentage of .350.
• Among all qualifying hitters in baseball, his batting average ranks seventh, his on-base percentage ranks 37th, and he is 103rd in slugging.
• Pete Crow-Armstrong has 37 doubles, four triples, 29 home runs and 29 walks. He's batting .246 and slugging .481 with an on-base percentage of .287.
• Among all qualifying players, he is 98th in batting average, 136th in on-base percentage and 28th in slugging percentage.
• Ian Happ is batting .241 with a .422 slugging percentage and 73 RBI this year.
• Seiya Suzuki has been key for Chicago with 132 hits, an OBP of .324 plus a slugging percentage of .459.

Reds Player Leaders

• Elly De La Cruz has a slugging percentage of .430 and has 156 hits, both team-best numbers for the Reds. He's batting .261 and with an on-base percentage of .332.
• Including all the qualifying hitters in the big leagues, his batting average puts him 60th, his on-base percentage ranks 65th, and he is 73rd in slugging.
• TJ Friedl's .362 OBP leads his team. He has a batting average of .257 while slugging .368.
• Including all qualified hitters, his batting average places him 75th, his on-base percentage is 17th, and he is 132nd in slugging.
• Spencer Steer is batting .240 with 20 doubles, two triples, 18 home runs and 45 walks.
• Austin Hays is batting .269 with 16 doubles, five triples, 15 home runs and 29 walks.

Cubs vs Reds Head to Head

• 9/18/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/6/2025: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 5-1 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/4/2025: 3-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/1/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/31/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/30/2025: 6-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/25/2025: 11-8 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/24/2025: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/23/2025: 13-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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