Astros vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 7:11 p.m.

The Houston Astros are among the MLB squads in action on Friday, versus the Seattle Mariners.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Mariners Game Info

• Houston Astros (84-69) vs. Seattle Mariners (84-69)
• Date: Friday, September 19, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and ROOT Sports NW

Astros vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-116) | SEA: (-102)
• Spread: HOU: +1.5 (-205) | SEA: -1.5 (+168)
• Total: 8 -- Over: (-100) | Under: (-122)

Astros vs Mariners Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 12-7, 2.27 ERA vs Bryan Woo (Mariners) - 14-7, 3.02 ERA

The Astros will give the nod to Hunter Brown (12-7, 2.27 ERA), who is eyeing win No. 13 on the season, and the Mariners will turn to Bryan Woo (14-7, 3.02 ERA). When Brown starts, his team is 17-12-0 against the spread this season. Brown's team has been victorious in 59.1% of the games he's started as the moneyline favorite with a record of 13-9. The Mariners have gone 12-17-0 against the spread when Woo starts. The Mariners have been the underdog on the moneyline in six of Woo's starts this season, and they went 3-3 in those matchups.

Astros vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (52.6%)

Astros vs Mariners Moneyline

• Looking at the moneyline for Mariners-Astros, Seattle is the underdog at -102, and Houston is -116 playing at home.

Astros vs Mariners Spread

• The Mariners are 1.5-run favorites against the spread for this matchup with the Astros. The Mariners are +168 to cover, while the Astros are -205 to cover as a 1.5-run underdog on the runline.

Astros vs Mariners Over/Under

• A total of 8 runs has been set for the Astros-Mariners contest on Sept. 19, with the over available at -100 and the under at -122.

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Astros vs Mariners Betting Trends

• The Astros have been chosen as favorites in 94 games this year and have walked away with the win 50 times (53.2%) in those games.
• This season Houston has come away with a win 47 times in 89 chances when named as a favorite of at least -116 on the moneyline.
• The Astros' games have gone over the total in 69 of their 152 opportunities.
• The Astros are 77-75-0 against the spread in their 152 games that had a posted line this season.
• The Mariners have compiled an 18-21 record in games they were listed as the moneyline underdog (winning 46.2% of those games).
• Seattle has a record of 17-17 in games it has played as a moneyline underdog with odds of -102 or longer (50%).
• In the 148 games oddsmakers have set an over/under for the Mariners, they have combined with opponents to go over the total 80 times (80-63-5).
• The Mariners are 65-83-0 ATS this season.

Astros Player Leaders

• Jose Altuve has an OPS of .768, fueled by an OBP of .324 and a team-best slugging percentage of .444 this season. He has a .263 batting average.
• He ranks 54th in batting average, 82nd in on-base percentage, and 64th in slugging among qualifying batters in MLB.
• Altuve hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .313 with two home runs and five RBIs.
• Jeremy Pena has 148 hits and an OBP of .364 to go with a slugging percentage of .474. All three of those stats rank first among Houston hitters this season. He's batting .305.
• His batting average is fourth among qualified players, his on-base percentage 15th, and his slugging percentage 36th.
• Pena heads into this matchup looking to extend his six-game hit streak. During his last 10 outings he is hitting .318 with four doubles, a home run, two walks and five RBIs.
• Yainer Diaz has collected 131 base hits, an OBP of .287 and a slugging percentage of .418 this season.
• Diaz heads into this game with two games in a row with at least one hit. In his last five games he is batting .333 with a double and five RBIs.
• Carlos Correa has 13 home runs, 50 RBI and a batting average of .276 this season.
• Correa takes a three-game hitting streak into this matchup. During his last five outings he is hitting .316 with two doubles and three walks.

Mariners Player Leaders

• Cal Raleigh has put up a team-best OBP (.359), and leads the Mariners in hits (139). He's batting .247 and slugging.
• Including all qualifying players, he is 97th in batting average, while his on-base percentage is 21st and he is third in slugging.
• Raleigh brings a six-game hitting streak into this game. In his last 10 games he is hitting .314 with three doubles, three home runs, 10 walks and five RBIs.
• Julio Rodriguez is slugging .475 to pace his team. He has a batting average of .269 with an on-base percentage of .321.
• Including all qualifying players, his batting average puts him 40th, his on-base percentage ranks 92nd, and he is 33rd in slugging.
• Josh Naylor has 26 doubles, a triple, 19 home runs and 47 walks while hitting .287.
• Eugenio Suarez has 26 doubles, 46 home runs and 44 walks while batting .228.

Astros vs Mariners Head to Head

• 7/20/2025: 11-3 HOU (Favorite: Mariners, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/19/2025: 7-6 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/18/2025: 6-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/25/2025: 5-3 HOU (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/24/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2025: 5-3 SEA (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/22/2025: 9-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/9/2025: 7-6 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/8/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/7/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)

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