Cubs vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 2:11 a.m.

The Friday slate in MLB includes a matchup between the Chicago Cubs and the Tampa Bay Rays.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Cubs vs Rays Game Info

• Chicago Cubs (83-63) vs. Tampa Bay Rays (72-74)
• Date: Friday, September 12, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MLB Network, MARQ, and FDSSUN

Cubs vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-172) | TB: (+144)
• Spread: CHC: -1.5 (+126) | TB: +1.5 (-152)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Cubs vs Rays Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 12-8, 2.92 ERA vs Shane Baz (Rays) - 9-11, 4.94 ERA

The probable pitchers are Matthew Boyd (12-8) for the Cubs and Shane Baz (9-11) for the Rays. Boyd's team is 10-17-0 against the spread in his starts this season. Boyd's team is 11-10 this season when he starts and they are the moneyline favorite. When Baz starts, the Rays have gone 12-15-0 against the spread. The Rays have been the moneyline underdog in 11 of Baz's starts this season, and they went 5-6 in those games.

Cubs vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (56.3%)

Cubs vs Rays Moneyline

• Tampa Bay is the underdog, +144 on the moneyline, while Chicago is a -172 favorite at home.

Cubs vs Rays Spread

• The Rays are +1.5 on the run line against the Cubs. The Rays are -152 to cover, and the Cubs are +126.

Cubs vs Rays Over/Under

• Cubs versus Rays, on Sept. 12, has an over/under of 7.5, with the over being -100 and the under -122.

Bet on Chicago Cubs vs. Tampa Bay Rays on FanDuel today!

Cubs vs Rays Betting Trends

• The Cubs have come away with 62 wins in the 99 contests they have been listed as the favorites in this season.
• Chicago has a record of 23-12 in contests when oddsmakers favor them by -172 or more on the moneyline.
• The Cubs and their opponents have gone over in 65 of their 142 games with a total set by sportsbooks this season.
• The Cubs are 65-77-0 against the spread in their 142 games that had a posted line this season.
• The Rays have been the underdog on the moneyline 67 total times this season. They've finished 28-39 in those games.
• In games it has played as a moneyline underdog with odds of +144 or longer, Tampa Bay has gone 3-6 (33.3%).
• In the 141 games bookmakers have set an over/under for the Rays, they have combined with opponents to go over the total 61 times (61-73-7).
• The Rays have put together a 61-80-0 record ATS this season.

Cubs Player Leaders

• Pete Crow-Armstrong has 134 hits, which leads Chicago hitters this season, while batting .251 with 67 extra-base hits. He has an on-base percentage of .294 and a slugging percentage of .490.
• He ranks 92nd in batting average, 134th in on-base percentage, and 24th in slugging among qualified hitters in MLB.
• Nico Hoerner has hit six homers this season while driving in 56 runs. He's batting .294 this season and slugging .390 with an on-base percentage of .343.
• Among qualified batters, his batting average ranks him eighth, his on-base percentage 47th, and his slugging percentage 115th.
• Hoerner heads into this game looking to extend his six-game hit streak. In his last 10 outings he is hitting .317 with four doubles, a home run, three walks and three RBIs.
• Seiya Suzuki has 131 hits this season and has a slash line of .244/.324/.461.
• Suzuki has recorded at least one base hit in six straight games. In his last 10 games he is hitting .211 with a double, six walks and four RBIs.
• Ian Happ has been key for Chicago with 121 hits, an OBP of .338 plus a slugging percentage of .408.
• Happ has safely hit in two games in a row. During his last five outings he is hitting .190 with a double and two walks.

Rays Player Leaders

• Junior Caminero has collected 144 hits, a team-best for the Rays. He's batting .261 and slugging .538 with an on-base percentage of .300.
• Including all qualifying hitters, he is 70th in batting average, while his on-base percentage ranks 124th and he is 10th in slugging.
• Yandy Diaz leads his team with a .350 on-base percentage, and has a club-best .474 slugging percentage. He has a batting average of .292.
• He is currently 11th in batting average, 37th in on-base percentage and 35th in slugging percentage among all qualified hitters.
• Brandon Lowe is batting .260 with 17 doubles, 28 home runs and 36 walks.
• Chandler Simpson is hitting .292 with 11 doubles, three triples and 18 walks.

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