Cubs vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 2:11 p.m.

Friday's slate in the MLB includes a matchup between the Chicago Cubs and the Tampa Bay Rays.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this matchup.

Cubs vs Rays Game Info

• Chicago Cubs (83-63) vs. Tampa Bay Rays (72-74)
• Date: Friday, September 12, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MLB Network, MARQ, and FDSSUN

Cubs vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-162) | TB: (+136)
• Spread: CHC: -1.5 (+130) | TB: +1.5 (-156)
• Total: 7 -- Over: (-120) | Under: (-102)

Cubs vs Rays Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 12-8, 2.92 ERA vs Shane Baz (Rays) - 9-11, 4.94 ERA

The Cubs will give the ball to Matthew Boyd (12-8, 2.92 ERA), who is eyeing win No. 13 on the season, and the Rays will counter with Shane Baz (9-11, 4.94 ERA). When Boyd starts, his team is 10-17-0 against the spread this season. Boyd's team is 11-10 this season when he starts and they are the moneyline favorite. The Rays are 12-15-0 ATS in Baz's 27 starts that had a set spread. The Rays have been the underdog on the moneyline in 11 of Baz's starts this season, and they went 5-6 in those games.

Cubs vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (56.6%)

Cubs vs Rays Moneyline

• The moneyline numbers for Cubs vs. Rays reveal Chicago as the favorite (-162) and Tampa Bay as the underdog (+136) on the road.

Cubs vs Rays Spread

• The Rays are +1.5 on the spread (-156 to cover), and Chicago is +130 to cover the runline.

Cubs vs Rays Over/Under

• A combined run total of 7 has been set for Cubs-Rays on Sept. 12, with the over at -120 and the under at -102.

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Cubs vs Rays Betting Trends

• The Cubs have come away with 62 wins in the 99 contests they have been listed as the favorites in this season.
• Chicago has a record of 27-16 when favored by -162 or more this year.
• The Cubs and their opponents have hit the over in 65 of their 142 games with a total set by oddsmakers this season.
• The Cubs have posted a record of 65-77-0 against the spread this season.
• The Rays have gone 28-39 in games they were the underdog on the moneyline (winning 41.8% of those games).
• Tampa Bay has gone 5-9 in games it has played as a moneyline underdog with odds of +136 or longer (35.7%).
• The Rays have had an over/under set by oddsmakers 141 times, and have combined with opponents to go over the total in 61 of those games (61-73-7).
• The Rays have collected a 61-80-0 record against the spread this season.

Cubs Player Leaders

• Pete Crow-Armstrong has 134 hits, which is best among Chicago hitters this season, while batting .251 with 67 extra-base hits. He has an on-base percentage of .294 and a slugging percentage of .490.
• Among all qualifying batters in the majors, he ranks 92nd in batting average, 134th in on-base percentage, and 24th in slugging.
• Nico Hoerner has hit six homers this season while driving in 56 runs. He's batting .294 this season and slugging .390 with an on-base percentage of .343.
• His batting average is eighth among qualified players, his on-base percentage 48th, and his slugging percentage 115th.
• Hoerner takes a six-game streak with at least one hit into this one. In his last 10 games he is batting .317 with four doubles, a home run, three walks and three RBIs.
• Seiya Suzuki has collected 131 base hits, an OBP of .324 and a slugging percentage of .461 this season.
• Suzuki has logged a hit or more in six games in a row. During his last 10 games he is batting .211 with a double, six walks and four RBIs.
• Ian Happ has 20 home runs, 66 RBI and a batting average of .237 this season.
• Happ enters this matchup on a two-game hitting streak. During his last five outings he is hitting .190 with a double and two walks.

Rays Player Leaders

• Junior Caminero has totaled 144 hits, a team-best for the Rays. He's batting .261 and slugging .538 with an on-base percentage of .300.
• Including all the qualifying hitters in the big leagues, his batting average is 71st, his on-base percentage ranks 124th, and he is ninth in slugging.
• Yandy Diaz's .350 on-base percentage and .474 slugging percentage are both team-highs. He has a batting average of .292.
• Including all qualified players, his batting average places him 11th, his on-base percentage ranks 37th, and he is 34th in slugging.
• Brandon Lowe is hitting .260 with 17 doubles, 28 home runs and 36 walks.
• Chandler Simpson is hitting .292 with 11 doubles, three triples and 18 walks.

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