Cubs vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 1:13 a.m.

The Chicago Cubs will take on the Washington Nationals in MLB action on Saturday.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Nationals Game Info

• Chicago Cubs (81-60) vs. Washington Nationals (56-84)
• Date: Saturday, September 6, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and MASN2

Cubs vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-275) | WSH: (+225)
• Spread: CHC: -1.5 (-125) | WSH: +1.5 (+104)
• Total: 9 -- Over: (-110) | Under: (-110)

Cubs vs Nationals Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 12-7, 2.94 ERA vs Brad Lord (Nationals) - 4-8, 4.34 ERA

The probable starters are Matthew Boyd (12-7) for the Cubs and Brad Lord (4-8) for the Nationals. Boyd and his team have a record of 10-16-0 against the spread when he starts. Boyd's team has been victorious in 55% of the games he's started as the moneyline favorite with a record of 11-9. When Lord starts, the Nationals are 7-6-0 against the spread. The Nationals have been the moneyline underdog in 11 of Lord's starts this season, and they went 7-4 in those matchups.

Cubs vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (69.8%)

Cubs vs Nationals Moneyline

• Chicago is a -275 favorite on the moneyline, while Washington is a +225 underdog on the road.

Cubs vs Nationals Spread

• The Nationals are at +1.5 on the runline against the Cubs. The Nationals are +104 to cover the spread, and the Cubs are -125.

Cubs vs Nationals Over/Under

• A combined run total of 9 has been set for Cubs-Nationals on Sept. 6, with the over at -110 and the under at -110.

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Cubs vs Nationals Betting Trends

• The Cubs have won in 62, or 64.6%, of the 96 contests they have been named as odds-on favorites in this year.
• Chicago has not lost in four games this year when favored by -275 or better on the moneyline.
• The Cubs and their opponents have gone over in 64 of their 137 games with a total set by sportsbooks this season.
• The Cubs are 63-74-0 against the spread in their 137 games that had a posted line this season.
• The Nationals have put together a 48-65 record in games they were the underdog on the moneyline (winning 42.5% of those games).
• Washington has played as a moneyline underdog of +225 or longer in just two games this season, which it lost both.
• The Nationals have combined with opponents to go over the total 71 times this season for a 71-56-7 record against the over/under.
• The Nationals have a 66-68-0 record against the spread this season (covering 49.3% of the time).

Cubs Player Leaders

• Kyle Tucker has 132 hits this season and a team-best OBP of .381. He has a .270 batting average and a slugging percentage of .472.
• Among all qualifying batters, he ranks 43rd in batting average, his on-base percentage ranks seventh, and he is 38th in slugging.
• Pete Crow-Armstrong has 132 hits, which is best among Chicago batters this season. He's batting .253 with 66 extra-base hits. He's also slugging .494 with an on-base percentage of .291.
• He ranks 88th in batting average, 141st in on-base percentage and 26th in slugging in MLB.
• Crow-Armstrong has picked up a hit in two straight games. In his last five games he is batting .167 with two walks and three RBIs.
• Nico Hoerner has an OPS of .724, fueled by an OBP of .339 and a team-best slugging percentage of .386 this season.
• Seiya Suzuki is batting .244 with a .323 OBP and 89 RBI for Chicago this season.

Nationals Player Leaders

• C.J. Abrams has 29 doubles, five triples, 17 home runs and 34 walks while batting .265. He's slugging .446 with an on-base percentage of .327.
• He ranks 60th in batting average, 84th in on-base percentage and 67th in slugging percentage among all qualifying batters in MLB.
• James Wood's 134 hits, .353 OBP and .470 slugging percentage are all team-highs. He has a batting average of .256.
• He is 86th in batting average, 36th in on-base percentage and 42nd in slugging percentage in the big leagues.
• Luis Garcia is hitting .260 with 26 doubles, a triple, 12 home runs and 23 walks.
• Josh Bell is hitting .225 with 13 doubles, a triple, 16 home runs and 54 walks.

Cubs vs Nationals Head to Head

• 9/5/2025: 11-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/4/2025: 2-0 WSH (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/3/2025: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/21/2024: 5-1 WSH (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/20/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/19/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/1/2024: 14-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/31/2024: 5-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/30/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)

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