Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 6:12 a.m.

On Sunday in MLB, the Chicago Cubs are playing the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Cubs vs Cardinals Game Info

• Chicago Cubs (91-70) vs. St. Louis Cardinals (78-83)
• Date: Sunday, September 28, 2025
• Time: 3:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and FDSMW

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-164) | STL: (+138)
• Spread: CHC: -1.5 (+132) | STL: +1.5 (-160)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Javier Assad (Cubs) - 3-1, 4.26 ERA vs Kyle Leahy (Cardinals) - 4-2, 3.18 ERA

The probable starters are Javier Assad (3-1) for the Cubs and Kyle Leahy (4-2) for the Cardinals. Assad's team is 1-5-0 against the spread in his starts this season. Assad's team has won each of the four games he's started as the moneyline favorite. Leahy and his team were moneyline underdogs in every game he pitched a season ago.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (61.3%)

Cubs vs Cardinals Moneyline

• Chicago is the favorite, -164 on the moneyline, while St. Louis is a +138 underdog on the road.

Cubs vs Cardinals Spread

• The Cubs are favored by 1.5 runs at home versus the Cardinals. The Cubs are +132 to cover the spread, while the Cardinals are -160.

Cubs vs Cardinals Over/Under

• An over/under of 8.5 has been set for Cubs-Cardinals on Sept. 28, with the over being -100 and the under -122.

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Cubs vs Cardinals Betting Trends

• The Cubs have come away with 69 wins in the 107 contests they have been listed as the favorites in this season.
• This year Chicago has won 28 of 43 games when listed as at least -164 on the moneyline.
• The Cubs and their opponents have gone over the total this season in 74 of their 156 opportunities.
• The Cubs have an against the spread record of 74-82-0 in 156 games with a line this season.
• The Cardinals have been the moneyline underdog 89 total times this season. They've finished 43-46 in those games.
• St. Louis has a record of 8-16 in games it has played as a moneyline underdog with odds of +138 or longer (33.3%).
• The Cardinals have combined with opponents to hit the over on the total 80 times this season for an 80-70-5 record against the over/under.
• The Cardinals have covered 50.3% of their games this season, going 78-77-0 against the spread.

Cubs Player Leaders

• Kyle Tucker leads Chicago with an OBP of .379 this season while batting .268 with 87 walks and 91 runs scored. He has a slugging percentage of .467.
• Among all qualifying hitters in baseball, he ranks 42nd in batting average, seventh in on-base percentage, and 42nd in slugging.
• Nico Hoerner has hit seven homers this season while driving in 61 runs. He's batting .297 this season and slugging .395 with an on-base percentage of .346.
• Among all qualified batters, he is eighth in batting average, 44th in on-base percentage and 110th in slugging percentage.
• Pete Crow-Armstrong has collected 145 base hits, an OBP of .287 and a slugging percentage of .481 this season.
• Crow-Armstrong has logged a hit or more in three straight games. In his last five games he is hitting .294 with two home runs and five RBIs.
• Michael Busch leads Chicago in total hits (137) this season while batting .263 with 64 extra-base hits.
• Busch takes a two-game hitting streak into this game. In his last five games he is batting .471 with three doubles, a triple, four home runs, four walks and eight RBIs.

Cardinals Player Leaders

• Alec Burleson has racked up a team-high slugging percentage (.459) and paces the Cardinals in hits (144). He's batting .290 and with an on-base percentage of .343.
• Including all the qualifying hitters in the big leagues, he is 15th in batting average, 50th in on-base percentage and 49th in slugging percentage.
• Brendan Donovan's .353 OBP paces his team. He has a batting average of .287 while slugging .422.
• He is 17th in batting average, 30th in on-base percentage and 80th in slugging percentage in the big leagues.
• Ivan Herrera is hitting .286 with 13 doubles, 19 home runs and 43 walks.
• Lars Nootbaar is batting .234 with 24 doubles, a triple, 13 home runs and 64 walks.

Cubs vs Cardinals Head to Head

• 9/27/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 9/26/2025: 12-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 8/9/2025: 9-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/8/2025: 5-0 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/5/2025: 8-6 STL (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/4/2025: 11-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/26/2025: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/25/2025: 8-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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