Creighton vs South Dakota College Basketball Prediction, Odds, Picks, Best Bets for Nov. 5

The Creighton Bluejays (0-0) take on the South Dakota Coyotes (0-1) on November 5, 2025.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Creighton vs. South Dakota Game Info and Odds

• Game day: Wednesday, November 5, 2025
• Game time: 8 p.m. ET
• TV channel: Peacock
• Location: Omaha, Nebraska
• Arena: CHI Health Center Omaha

Creighton vs. South Dakota Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Creighton win (95.5%)

Before making a bet on Wednesday's Creighton-South Dakota spread (Creighton -29.5) or over/under (170.5 points), take a look at the betting trends and insights below.

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Creighton vs. South Dakota: ATS Betting Stats and Trends

• Creighton put together a 22-14-0 record against the spread last season.
• South Dakota put together a 15-14-0 record against the spread last season.
• When playing at home last season, the Bluejays had a worse record against the spread (11-6-0) compared to their ATS record in road games (9-2-0).
• The Coyotes were better against the spread at home (8-4-0) than away (6-9-0) last year.

Creighton vs. South Dakota: Moneyline Betting Stats

• Creighton put together a 17-4 record in games it was listed as the moneyline favorite last season (winning 81% of those games).
• The Bluejays played as a moneyline favorite of -33333 or shorter in only one game last season, which they won.
• South Dakota was underdogs in 16 games last season and won four (25%) of those contests.
• The Coyotes were not a bigger underdog last season than the +4000 moneyline set for this game.
• Creighton has an implied moneyline win probability of 99.7% in this matchup.

Creighton vs. South Dakota Head-to-Head Comparison

• Creighton put up 75.5 points per game and gave up 70.0 last season, ranking them 131st in the nation on offense and 110th on defense.
• Last year, Creighton was 53rd in the nation in rebounds (34.4 per game) and 172nd in rebounds conceded (31.1).
• Creighton was 13th-best in the nation in assists (17.1 per game) last season.
• Last season, Creighton was 215th in the nation in turnovers committed (11.4 per game) and -4-worst in turnovers forced (7.4).
• South Dakota had to lean on its offense, which ranked third-best in college basketball (85.2 points per game), last season, as it ranked -3-worst in college basketball defensively with just 83.7 points allowed per contest.
• South Dakota, who ranked 152nd in college basketball with 32.5 boards per game, allowed 35.9 rebounds per contest, which was second-worst in the nation.
• Last year South Dakota ranked 330th in college basketball in assists, dishing out 11.3 per game.
• South Dakota ranked 19th-best in college basketball by averaging only 9.2 turnovers per game. In terms of forced turnovers, it ranked 62nd in college basketball (12.7 per contest).

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