Colorado vs Wyoming Prediction, Odds, Picks, Best Bets for Week 4 2025

The Colorado Buffaloes versus the Wyoming Cowboys is on the college football schedule for Saturday.

We've got you covered, in terms of the vital information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Colorado vs Wyoming Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Colorado: (-500) | Wyoming: (+375)
• Spread: Colorado: -13.5 (-105) | Wyoming: +13.5 (-115)
• Total: 45.5 -- Over: (-110) | Under: (-110)

Colorado vs Wyoming Betting Trends

• Colorado has one win against the spread this season.
• Colorado has covered every time (1-0) as a 13.5-point favorite or greater this season.
• One of three Colorado games have hit the over this season.
• Wyoming owns two wins against the spread this season.
• Wyoming is winless ATS (0-1) when playing as at least 13.5-point underdogs this year.
• Not one of Wyoming's three games has gone over the point total in 2025.

Colorado vs Wyoming Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buffaloes win (87.6%)

Colorado vs Wyoming Point Spread

Colorado is a 13.5-point favorite against Wyoming. Colorado is -105 to cover the spread, and Wyoming is -115.

Colorado vs Wyoming Over/Under

A combined point total of 45.5 has been set for Colorado-Wyoming on Sept. 20, with the over at -110 and the under at -110.

Colorado vs Wyoming Moneyline

Wyoming is a +375 underdog on the moneyline, while Colorado is a -500 favorite.

Colorado vs. Wyoming Points Insights

Colorado vs. Wyoming Game Info

• Game day: Saturday, September 20, 2025
• Game time: 10:15 p.m. ET
• TV channel: ESPN
• Location: Boulder, Colorado
• Stadium: Folsom Field

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