Central Michigan vs Buffalo Prediction, Odds, Picks, Best Bets for Week 12 2025

The Central Michigan Chippewas will take on the Buffalo Bulls in college football action on Wednesday.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Central Michigan vs Buffalo Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Central Michigan: (-124) | Buffalo: (+106)
• Spread: Central Michigan: -1.5 (-115) | Buffalo: +1.5 (-105)
• Total: 44.5 -- Over: (-105) | Under: (-115)

Central Michigan vs Buffalo Betting Trends

• Central Michigan is 6-3-0 against the spread this year.
• Against the spread as 1.5-point or better favorites, Central Michigan is 3-1.
• This season, six of Central Michigan's nine games have hit the over.
• Buffalo has beaten the spread four times in nine games.
• Buffalo's ATS record as 1.5-point underdogs or more is 3-0.
• Buffalo has seen four of its nine games go over the point total.

Central Michigan vs Buffalo Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Chippewas win (71.3%)

Central Michigan vs Buffalo Point Spread

Central Michigan is a 1.5-point favorite against Buffalo. Central Michigan is -115 to cover the spread, and Buffalo is -105.

Central Michigan vs Buffalo Over/Under

The over/under for the Central Michigan versus Buffalo matchup on Nov. 12 has been set at 44.5, with -105 odds on the over and -115 odds on the under.

Central Michigan vs Buffalo Moneyline

Buffalo is the underdog, +106 on the moneyline, while Central Michigan is a -124 favorite.

Central Michigan vs. Buffalo Points Insights

Central Michigan vs. Buffalo Game Info

• Game day: Wednesday, November 12, 2025
• Game time: 7 p.m. ET
• TV channel: CBS Sports Network
• Location: Mount Pleasant, Michigan
• Stadium: Kelly/Shorts Stadium

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Check out even more in-depth Central Michigan vs. Buffalo analysis on FanDuel Research.