Central Michigan vs Buffalo Prediction, Odds, Picks, Best Bets for Week 12 2025

The Central Michigan Chippewas are among the college football squads busy on Wednesday, up against the Buffalo Bulls.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding today's NCAA football betting odds.

Central Michigan vs Buffalo Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Central Michigan: (-130) | Buffalo: (+110)
• Spread: Central Michigan: -2.5 (-105) | Buffalo: +2.5 (-115)
• Total: 44.5 -- Over: (-110) | Under: (-110)

Central Michigan vs Buffalo Betting Trends

• Against the spread, Central Michigan is 6-3-0 this season.
• For the year, Central Michigan is 3-1 as 2.5-point or better favorites.
• This season, six of Central Michigan's nine games have gone over the point total.
• Buffalo has beaten the spread four times in nine games.
• Buffalo is unbeaten ATS (2-0) as a 2.5-point underdog or greater this year.
• There have been four Buffalo games (out of nine) that hit the over this season.

Central Michigan vs Buffalo Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Chippewas win (74.2%)

Central Michigan vs Buffalo Point Spread

Central Michigan is favored by 2.5 points over Buffalo. Central Michigan is -105 to cover the spread, with Buffalo being -115.

Central Michigan vs Buffalo Over/Under

An over/under of 44.5 has been set for Central Michigan-Buffalo on Nov. 12, with the over being -110 and the under -110.

Central Michigan vs Buffalo Moneyline

Looking at the moneyline for Buffalo-Central Michigan, Buffalo is the underdog at +110, and Central Michigan is -130.

Central Michigan vs. Buffalo Points Insights

Central Michigan vs. Buffalo Game Info

• Game day: Wednesday, November 12, 2025
• Game time: 7 p.m. ET
• TV channel: CBS Sports Network
• Location: Mount Pleasant, Michigan
• Stadium: Kelly/Shorts Stadium

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