Cavaliers vs. 76ers Prediction, Odds, Picks, Best Bets for Nov. 5

Cavaliers vs. 76ers Game Info

• Date: Wednesday, November 5, 2025
• Time: 7 p.m. ET
• Venue: Rocket Arena -- Cleveland, Ohio
• Coverage: FDSOH and NBCS-PH

The Cleveland Cavaliers (4-3) face the Philadelphia 76ers (5-2) as heavy, 10.5-point favorites on Wednesday, November 5, 2025 at 7 p.m. ET on FDSOH and NBCS-PH. The matchup's over/under is set at 233.5.

Cavaliers vs. 76ers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Cavaliers vs. 76ers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (87.2%)

Cavaliers vs. 76ers Betting Trends

• The Cavaliers have covered the spread in a game two times this season (2-5-0).
• The 76ers have four wins against the spread in seven games this season.
• Cavaliers games have gone over the total twice this season.
• 76ers games this season have eclipsed the over/under 71.4% of the time (five out of seven games with a set point total).

Cavaliers Leaders

• Evan Mobley averages 19.3 points, 8.9 rebounds and 4.4 assists.
• Donovan Mitchell averages 29.5 points, 2.3 boards and 4.5 assists, shooting 55% from the field and 43.6% from downtown, with 4 made treys per game (third in league).
• De'Andre Hunter is averaging 18.4 points, 3 assists and 5.6 rebounds.
• Jarrett Allen averages 14 points, 7 rebounds and 1.8 assists, shooting 57.5% from the floor.
• Jaylon Tyson is averaging 10.9 points, 2.7 boards and 1.6 assists. At the other end, he averages 0.9 steals and 0.7 blocked shots.

76ers Leaders

• Tyrese Maxey averages 34.4 points, 4.9 rebounds and 8.4 assists. He is also sinking 47.5% of his shots from the field and 48.5% from beyond the arc, with 4.6 triples per game (first in league).
• VJ Edgecombe's numbers on the season are 19.1 points, 5.9 boards and 4.9 assists per contest. He is draining 47.6% of his shots from the field and 43.9% from 3-point range, with an average of 2.6 triples.
• Kelly Oubre Jr.'s numbers on the season are 19.3 points, 5.9 rebounds and 1.3 assists per contest. He is sinking 53.9% of his shots from the floor and 42.5% from 3-point range, with an average of 2.4 triples.
• The 76ers are receiving 17 points, 4.4 boards and 5 assists per game from Quentin Grimes.
• The 76ers are receiving 17.8 points, 5.4 boards and 3.2 assists per game from Joel Embiid.

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