Cavaliers vs. 76ers Prediction, Odds, Picks, Best Bets for Nov. 5

Cavaliers vs. 76ers Game Info

• Date: Wednesday, November 5, 2025
• Time: 7 p.m. ET
• Venue: Rocket Arena -- Cleveland, Ohio
• Coverage: FDSOH and NBCS-PH

The Cleveland Cavaliers (4-3) are heavy, 10.5-point favorites against the Philadelphia 76ers (5-2) on Wednesday, November 5, 2025 at 7 p.m. ET. The matchup airs on FDSOH and NBCS-PH. The matchup has an over/under of 235.5 points.

Cavaliers vs. 76ers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Cavaliers vs. 76ers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (87.2%)

Cavaliers vs. 76ers Betting Trends

• The Cavaliers have put together a record of 2-5-0 against the spread this season.
• The 76ers have played seven games, with four wins against the spread.
• This season, Cavaliers games have hit the over twice.
• 76ers games this season have gone over the point total five times in seven opportunities (71.4%).

Cavaliers Leaders

• Evan Mobley averages 19.3 points, 8.9 rebounds and 4.4 assists.
• Donovan Mitchell averages 29.5 points, 2.3 boards and 4.5 assists.
• De'Andre Hunter's numbers on the season are 18.4 points, 5.6 boards and 3 assists per contest, shooting 38.4% from the floor and 27.9% from beyond the arc, with an average of 2.4 made treys.
• Jarrett Allen is averaging 14 points, 7 boards and 1.8 assists. At the other end, he averages 1.4 steals and 0.4 blocked shots.
• Jaylon Tyson is averaging 10.9 points, 1.6 assists and 2.7 rebounds.

76ers Leaders

• Tyrese Maxey is averaging 34.4 points, 4.9 boards and 8.4 assists for the 76ers.
• VJ Edgecombe's numbers on the season are 19.1 points, 5.9 rebounds and 4.9 assists per game. He is sinking 47.6% of his shots from the field and 43.9% from beyond the arc, with an average of 2.6 treys.
• Per game, Kelly Oubre Jr. gets the 76ers 19.3 points, 5.9 boards and 1.3 assists, plus 1.3 steals and 1 block.
• The 76ers are getting 17 points, 4.4 boards and 5 assists per game from Quentin Grimes.
• Joel Embiid averages 17.8 points, 5.4 rebounds and 3.2 assists. He is sinking 42.3% of his shots from the field and 33.3% from 3-point range, with 1.6 treys per contest.

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