Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 5:19 a.m.

The MLB's Friday schedule includes the Milwaukee Brewers taking on the St. Louis Cardinals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (94-59) vs. St. Louis Cardinals (74-79)
• Date: Friday, September 19, 2025
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSWI

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-118) | STL: (-100)
• Spread: MIL: -1.5 (+158) | STL: +1.5 (-192)
• Total: 7.5 -- Over: (-114) | Under: (-106)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 5-2, 4.35 ERA vs Sonny Gray (Cardinals) - 13-8, 4.43 ERA

The Brewers will give the nod to Jacob Misiorowski (5-2) versus the Cardinals and Sonny Gray (13-8). When Misiorowski starts, his team is 8-5-0 against the spread this season. When Misiorowski starts a game and his team is the favorite on the moneyline, they have a record of 4-3. The Cardinals are 14-14-0 ATS in Gray's 28 starts that had a set spread. The Cardinals have a 5-4 record in Gray's nine starts this season when they were the underdog on the moneyline.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.6%)

Brewers vs Cardinals Moneyline

• Milwaukee is the favorite, -118 on the moneyline, while St. Louis is a -100 underdog despite being at home.

Brewers vs Cardinals Spread

• The Cardinals are at +1.5 on the runline against the Brewers. The Cardinals are -192 to cover the spread, and the Brewers are +158.

Brewers vs Cardinals Over/Under

• The Brewers-Cardinals game on Sept. 19 has been given an over/under of 7.5 runs. The over is set at -114 and the under at -106.

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Brewers vs Cardinals Betting Trends

• The Brewers have won in 58, or 65.9%, of the 88 contests they have been named as odds-on favorites in this year.
• This year Milwaukee has won 53 of 78 games when listed as at least -118 on the moneyline.
• The Brewers and their opponents have gone over the total this season in 76 of their 150 opportunities.
• The Brewers have posted a record of 85-65-0 against the spread this season.
• The Cardinals have gone 39-43 in games they were the underdog on the moneyline (winning 47.6% of those games).
• St. Louis has a record of 27-38 in games it has played as a moneyline underdog with odds of -100 or longer (41.5%).
• The Cardinals have played in 147 games with an over/under set, and have combined with their opponents to go over the total 75 times (75-67-5).
• The Cardinals have collected a 73-74-0 record against the spread this season (covering 49.7% of the time).

Brewers Player Leaders

• Brice Turang has an OPS of .799, fueled by an OBP of .359 and a team-best slugging percentage of .440 this season. He has a .289 batting average.
• He ranks 13th in batting average, 21st in on-base percentage, and 66th in slugging among qualifying hitters in baseball.
• Turang has recorded a base hit in four straight games. In his last five games he is hitting .294 with a double, five walks and an RBI.
• William Contreras has 27 doubles, 17 home runs and 82 walks. He's batting .264 and slugging .406 with an on-base percentage of .359.
• Among qualifying batters, he is 51st in batting average, 21st in on-base percentage and 92nd in slugging percentage.
• Christian Yelich has collected 144 base hits, an OBP of .346 and a slugging percentage of .467 this season.
• Jackson Chourio leads Milwaukee with 141 hits, batting .277 this season with 58 extra-base hits.

Cardinals Player Leaders

• Alec Burleson has put up a slugging percentage of .461 and has 133 hits, both team-best numbers for the Cardinals. He's batting .285 and with an on-base percentage of .338.
• He is 19th in batting average, 57th in on-base percentage and 48th in slugging percentage among all qualifying hitters in the big leagues.
• Burleson heads into this game on a three-game hitting streak. During his last five outings he is hitting .333 with two doubles, a home run, two walks and three RBIs.
• Brendan Donovan's .348 OBP paces his team. He has a batting average of .281 while slugging .407.
• He is currently 22nd in batting average, 39th in on-base percentage and 91st in slugging percentage among all qualifying hitters.
• Lars Nootbaar is batting .237 with 23 doubles, a triple, 13 home runs and 59 walks.
• Ivan Herrera has 13 doubles, 16 home runs and 37 walks while hitting .280.

Brewers vs Cardinals Head to Head

• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2025: 6-0 MIL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/27/2025: 7-1 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/26/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/25/2025: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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