Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 8:15 p.m.

The MLB schedule on Friday includes the Milwaukee Brewers taking on the St. Louis Cardinals.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (94-59) vs. St. Louis Cardinals (74-79)
• Date: Friday, September 19, 2025
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSWI

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-118) | STL: (-100)
• Spread: MIL: -1.5 (+136) | STL: +1.5 (-164)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 5-2, 4.35 ERA vs Sonny Gray (Cardinals) - 13-8, 4.43 ERA

This contest's pitching matchup is set, as the Brewers will send Jacob Misiorowski (5-2) to the mound, while Sonny Gray (13-8) will take the ball for the Cardinals. When Misiorowski starts, his team is 8-5-0 against the spread this season. Misiorowski's team has won 57.1% of his starts when they are favored on the moneyline (4-3). The Cardinals are 14-14-0 ATS in Gray's 28 starts that had a set spread. The Cardinals have been the underdog on the moneyline in nine of Gray's starts this season, and they went 5-4 in those games.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (58.6%)

Brewers vs Cardinals Moneyline

• Milwaukee is the favorite, -118 on the moneyline, while St. Louis is a -100 underdog despite being at home.

Brewers vs Cardinals Spread

• The Brewers are at the Cardinals and are favored by 1.5 runs on the spread. The Brewers are +136 to cover the runline, with the Cardinals being -164.

Brewers vs Cardinals Over/Under

• A combined run total of 7.5 has been set for Brewers-Cardinals on Sept. 19, with the over at -112 and the under at -108.

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Brewers vs Cardinals Betting Trends

• The Brewers have been chosen as favorites in 88 games this year and have walked away with the win 58 times (65.9%) in those games.
• This season Milwaukee has come away with a win 53 times in 78 chances when named as a favorite of at least -118 on the moneyline.
• Contests with the Brewers have gone over the total set by sportsbooks in 76 of 150 chances this season.
• The Brewers are 85-65-0 against the spread in their 150 games with a line set by sportsbooks this season.
• The Cardinals have won 39 of the 82 games they were the moneyline underdog this season (47.6%).
• When it has played as a moneyline underdog with odds of -100 or longer, St. Louis has a record of 27-38 (41.5%).
• The Cardinals have combined with opponents to go over the total 75 times this season for a 75-67-5 record against the over/under.
• The Cardinals have a 73-74-0 record against the spread this season (covering 49.7% of the time).

Brewers Player Leaders

• Brice Turang has an OPS of .799, fueled by an OBP of .359 and a team-best slugging percentage of .440 this season. He has a .289 batting average.
• Among all qualified hitters in baseball, he ranks 13th in batting average, 21st in on-base percentage, and 66th in slugging.
• Turang hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .294 with a double, five walks and an RBI.
• William Contreras is hitting .264 with 27 doubles, 17 home runs and 82 walks, while slugging .406 with an on-base percentage of .359.
• He is 52nd in batting average, 21st in on-base percentage and 92nd in slugging among qualifying hitters.
• Christian Yelich is batting .268 with a .467 slugging percentage and 100 RBI this year.
• Jackson Chourio leads Milwaukee with 141 hits, batting .277 this season with 58 extra-base hits.

Cardinals Player Leaders

• Alec Burleson has a team-best slugging percentage (.461) and leads the Cardinals in hits (133). He's batting .285 and with an on-base percentage of .338.
• Including all qualifying hitters, he is 19th in batting average, while his on-base percentage is 57th and he is 48th in slugging.
• Burleson hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .333 with two doubles, a home run, two walks and three RBIs.
• Brendan Donovan has a .348 on-base percentage to lead his team. He has a batting average of .281 while slugging .407.
• He is currently 22nd in batting average, 39th in on-base percentage and 91st in slugging percentage among all qualifying hitters.
• Lars Nootbaar has 23 doubles, a triple, 13 home runs and 59 walks while hitting .237.
• Ivan Herrera is hitting .280 with 13 doubles, 16 home runs and 37 walks.

Brewers vs Cardinals Head to Head

• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2025: 6-0 MIL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/27/2025: 7-1 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/26/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/25/2025: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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