Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 13

Odds updated as of 8:13 p.m.

The MLB's Saturday schedule includes the Milwaukee Brewers taking on the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (90-58) vs. St. Louis Cardinals (72-76)
• Date: Saturday, September 13, 2025
• Time: 8:15 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: FOX

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-174) | STL: (+146)
• Spread: MIL: -1.5 (+128) | STL: +1.5 (-154)
• Total: 9 -- Over: (-105) | Under: (-115)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 5-2, 4.09 ERA vs Sonny Gray (Cardinals) - 13-8, 4.45 ERA

This contest's pitching matchup is set, as the Brewers will send Jacob Misiorowski (5-2) to the mound, while Sonny Gray (13-8) will answer the bell for the Cardinals. Misiorowski's team is 8-4-0 against the spread in his starts this season. Misiorowski's team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 3-3. The Cardinals have a 13-14-0 ATS record in Gray's 27 starts that had a set spread. The Cardinals have been the underdog on the moneyline in eight of Gray's starts this season, and they went 5-3 in those matchups.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (56.8%)

Brewers vs Cardinals Moneyline

• Milwaukee is a -174 favorite on the moneyline, while St. Louis is a +146 underdog on the road.

Brewers vs Cardinals Spread

• The Brewers are 1.5-run home favorites on the runline against the Cardinals. The Brewers are +128 to cover, and the Cardinals are -154.

Brewers vs Cardinals Over/Under

• An over/under of 9 has been set for Brewers-Cardinals on Sept. 13, with the over being -105 and the under -115.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have won in 54, or 65.1%, of the 83 contests they have been named as odds-on favorites in this year.
• This year Milwaukee has won 14 of 17 games when listed as at least -174 on the moneyline.
• Contests with the Brewers have gone over the total set by bookmakers in 73 of 145 chances this season.
• The Brewers are 82-63-0 against the spread in their 145 games with a line set by sportsbooks this season.
• The Cardinals have been the moneyline underdog 78 total times this season. They've gone 37-41 in those games.
• When playing as a moneyline underdog with odds of +146 or longer, St. Louis has a record of 3-13 (18.8%).
• In the 142 games bookmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 73 times (73-64-5).
• The Cardinals have covered 49.3% of their games this season, going 70-72-0 ATS.

Brewers Player Leaders

• Brice Turang leads Milwaukee with a slugging percentage of .443, fueled by 45 extra-base hits. He has a .289 batting average and an on-base percentage of .355.
• Among the qualifying batters in MLB, his batting average ranks 14th, his on-base percentage ranks 30th, and he is 63rd in slugging.
• Turang has picked up at least one hit in two straight games. During his last five outings he is hitting .227 with a home run, two walks and four RBIs.
• William Contreras is batting .261 with 26 doubles, 17 home runs and 79 walks, while slugging .405 with an on-base percentage of .357.
• His batting average is 69th among qualified players, his on-base percentage 23rd, and his slugging percentage 96th.
• Christian Yelich is batting .267 with a .464 slugging percentage and 95 RBI this year.
• Jackson Chourio leads Milwaukee with 137 hits, batting .281 this season with 57 extra-base hits.
• Chourio heads into this game on a five-game hitting streak. In his last five games he is batting .400 with two doubles, two home runs, two walks and five RBIs.

Cardinals Player Leaders

• Alec Burleson has put up a team-best slugging percentage (.455) and paces the Cardinals in hits (127). He's batting .283 and with an on-base percentage of .334.
• Including all the qualified hitters in the majors, his batting average ranks 19th, his on-base percentage is 62nd, and he is 52nd in slugging.
• Willson Contreras has 30 doubles, a triple, 20 home runs and 43 walks while hitting .254. He's slugging .443 with an on-base percentage of .338.
• Including all qualifying players, he is 88th in batting average, 54th in on-base percentage and 63rd in slugging percentage.
• Brendan Donovan has put up a team-high .347 on-base percentage.
• Lars Nootbaar is batting .242 with 22 doubles, a triple, 13 home runs and 56 walks.

Brewers vs Cardinals Head to Head

• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2025: 6-0 MIL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/27/2025: 7-1 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/26/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/25/2025: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/4/2024: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/3/2024: 7-4 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!