Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 13

Odds updated as of 6:12 a.m.

The Milwaukee Brewers versus the St. Louis Cardinals is on the MLB schedule for Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (90-58) vs. St. Louis Cardinals (72-76)
• Date: Saturday, September 13, 2025
• Time: 8:15 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: FOX

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-166) | STL: (+140)
• Spread: MIL: -1.5 (+138) | STL: +1.5 (-166)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 5-2, 4.09 ERA vs Sonny Gray (Cardinals) - 13-8, 4.45 ERA

The Brewers will give the nod to Jacob Misiorowski (5-2, 4.09 ERA), who is eyeing win No. 6 on the season, and the Cardinals will counter with Sonny Gray (13-8, 4.45 ERA). Misiorowski and his team are 8-4-0 ATS this season when he starts. Misiorowski's team has won 50% of his starts when they are favored on the moneyline (3-3). The Cardinals are 13-14-0 against the spread when Gray starts. The Cardinals have a 5-3 record in Gray's eight starts this season when they were the underdog on the moneyline.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (58.1%)

Brewers vs Cardinals Moneyline

• Looking at the moneyline for Brewers-Cardinals, Milwaukee is the favorite at -166, and St. Louis is +140 playing on the road.

Brewers vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-166 to cover), and Milwaukee is +138 to cover the runline.

Brewers vs Cardinals Over/Under

• The over/under for the Brewers versus Cardinals contest on Sept. 13 has been set at 7.5, with -115 odds on the over and -105 odds on the under.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have been chosen as favorites in 83 games this year and have walked away with the win 54 times (65.1%) in those games.
• This season Milwaukee has been victorious 15 times in 19 chances when named as a favorite of at least -166 on the moneyline.
• The Brewers and their opponents have gone over the total this season in 73 of their 145 opportunities.
• The Brewers have an against the spread record of 82-63-0 in 145 games with a line this season.
• The Cardinals have been the moneyline underdog 78 total times this season. They've gone 37-41 in those games.
• In games it has played as a moneyline underdog with odds of +140 or longer, St. Louis has a 5-13 record (winning just 27.8% of its games).
• In the 142 games bookmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 73 times (73-64-5).
• The Cardinals have collected a 70-72-0 record ATS this season.

Brewers Player Leaders

• Brice Turang has an OPS of .798, fueled by an OBP of .355 and a team-best slugging percentage of .443 this season. He has a .289 batting average.
• Among qualified hitters in the majors, he is 14th in batting average, 30th in on-base percentage, and 64th in slugging.
• Turang hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .227 with a home run, two walks and three RBIs.
• William Contreras is hitting .261 with 26 doubles, 17 home runs and 79 walks, while slugging .405 with an on-base percentage of .357.
• Among qualifying batters, his batting average places him 69th, his on-base percentage 23rd, and his slugging percentage 97th.
• Christian Yelich is batting .267 with a .464 slugging percentage and 95 RBI this year.
• Jackson Chourio has 137 hits, which ranks first among Milwaukee hitters this season, while batting .281 with 57 extra-base hits.
• Chourio enters this game on a five-game hitting streak. In his last five games he is batting .400 with two doubles, two home runs, two walks and five RBIs.

Cardinals Player Leaders

• Alec Burleson has a team-high slugging percentage (.455) while leading the Cardinals in hits (127). He's batting .283 and with an on-base percentage of .334.
• Including all the qualified hitters in MLB, he is 19th in batting average, 62nd in on-base percentage and 52nd in slugging percentage.
• Willson Contreras is hitting .254 with 30 doubles, a triple, 20 home runs and 43 walks. He's slugging .443 with an on-base percentage of .338.
• Including all qualified players, he ranks 88th in batting average, 54th in on-base percentage and 64th in slugging percentage.
• Brendan Donovan has racked up a team-best .347 on-base percentage.
• Masyn Winn is hitting .253 with 27 doubles, nine home runs and 34 walks.

Brewers vs Cardinals Head to Head

• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2025: 6-0 MIL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/27/2025: 7-1 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/26/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/25/2025: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/4/2024: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/3/2024: 7-4 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)

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