Blue Jays vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 2:12 p.m.

MLB action on Sunday includes the Toronto Blue Jays playing the Kansas City Royals.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Blue Jays vs Royals Game Info

• Toronto Blue Jays (89-66) vs. Kansas City Royals (78-77)
• Date: Sunday, September 21, 2025
• Time: 2:10 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: FDSKC and SNET

Blue Jays vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-124) | KC: (+106)
• Spread: TOR: -1.5 (+126) | KC: +1.5 (-152)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Blue Jays vs Royals Probable Starting Pitchers

Probable Pitchers: Trey Yesavage (Blue Jays) - 0-0, 1.80 ERA vs Michael Wacha (Royals) - 9-12, 3.79 ERA

The Blue Jays will give the nod to Trey Yesavage and the Royals will counter with Michael Wacha (9-12, 3.79 ERA). Yesavage and his team failed to cover the spread in his only opportunity this season as a starter. Yesavage's team won his only start as a favorite this season. When Wacha starts, the Royals have gone 12-17-0 against the spread. The Royals have been the moneyline underdog in 18 of Wacha's starts this season, and they went 8-10 in those games.

Blue Jays vs Royals Moneyline

• Toronto is a -124 favorite on the moneyline, while Kansas City is a +106 underdog at home.

Blue Jays vs Royals Spread

• The Blue Jays are favored by 1.5 runs on the road versus the Royals. The Blue Jays are +126 to cover the spread, while the Royals are -152.

Blue Jays vs Royals Over/Under

• Blue Jays versus Royals on Sept. 21 has an over/under of 8.5 runs, with the odds on the over -115 and the under set at -105.

Bet on Toronto Blue Jays vs. Kansas City Royals on FanDuel today!

Blue Jays vs Royals Betting Trends

• The Blue Jays have been chosen as favorites in 77 games this year and have walked away with the win 44 times (57.1%) in those games.
• This season Toronto has been victorious 41 times in 66 chances when named as a favorite of at least -124 on the moneyline.
• The Blue Jays' games have gone over the total in 83 of their 154 opportunities.
• The Blue Jays have posted a record of 87-67-0 against the spread this season.
• The Royals have won 41 of the 90 games they were the underdog on the moneyline this season (45.6%).
• Kansas City has a record of 25-36 when playing as a moneyline underdog with odds of +106 or longer (41%).
• In the 153 games oddsmakers have set an over/under for the Royals, they have combined with opponents to go over the total 66 times (66-85-2).
• The Royals have a 75-78-0 record ATS this season (covering 49% of the time).

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has 33 doubles, 23 home runs and 80 walks while batting .298. He has an on-base percentage of .389 and a slugging percentage of .480.
• Among qualifying hitters in baseball, his batting average ranks ninth, his on-base percentage ranks sixth, and he is 30th in slugging.
• George Springer leads Toronto with 143 hits and an OBP of .393 this season. He's batting .304 and slugging .550.
• Among qualified hitters, his batting average ranks him fifth, his on-base percentage fourth, and his slugging percentage fifth.
• Springer brings a two-game streak with at least one hit into this one. In his last five games he is hitting .350 with a double, a home run, a walk and three RBIs.
• Ernie Clement has collected 144 base hits, an OBP of .314 and a slugging percentage of .400 this season.
• Alejandro Kirk has been key for Toronto with 123 hits, an OBP of .352 plus a slugging percentage of .407.

Royals Player Leaders

• Bobby Witt Jr. has racked up 173 hits with a .352 on-base percentage and a .503 slugging percentage, all club-highs for the Royals. He's batting .293.
• Including all the qualifying hitters in MLB, he is 11th in batting average, 33rd in on-base percentage and 16th in slugging percentage.
• Vinnie Pasquantino has 30 doubles, a triple, 31 home runs and 47 walks while hitting .271. He's slugging .483 with an on-base percentage of .330.
• He ranks 38th in batting average, 69th in on-base percentage and 27th in slugging percentage in the big leagues.
• Maikel Garcia is hitting .283 with 36 doubles, five triples, 16 home runs and 59 walks.
• Salvador Perez is hitting .240 with 34 doubles, 30 home runs and 25 walks.

Blue Jays vs Royals Head to Head

• 9/20/2025: 2-1 KC (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/19/2025: 20-1 KC (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/3/2025: 7-4 KC (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/2/2025: 4-2 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/1/2025: 9-3 KC (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/1/2024: 6-1 KC (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/30/2024: 4-1 KC (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/29/2024: 6-5 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/25/2024: 2-1 KC (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/24/2024: 3-2 KC (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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