Blue Jays vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 6:13 p.m.

The Tuesday schedule in MLB includes a matchup between the Toronto Blue Jays and the Boston Red Sox.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Blue Jays vs Red Sox Game Info

• Toronto Blue Jays (90-66) vs. Boston Red Sox (85-71)
• Date: Tuesday, September 23, 2025
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SNET and NESN

Blue Jays vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-166) | BOS: (+140)
• Spread: TOR: -1.5 (+130) | BOS: +1.5 (-156)
• Total: 8 -- Over: (-105) | Under: (-115)

Blue Jays vs Red Sox Probable Starting Pitchers

Probable Pitchers: Kevin Gausman (Blue Jays) - 10-10, 3.38 ERA vs Lucas Giolito (Red Sox) - 10-4, 3.46 ERA

The Blue Jays will look to Kevin Gausman (10-10) versus the Red Sox and Lucas Giolito (10-4). Gausman and his team have a record of 14-16-0 against the spread when he starts. Gausman's team has won 40% of his starts when they are favored on the moneyline (6-9). The Red Sox have a 16-9-0 record against the spread in Giolito's starts. The Red Sox have been the moneyline underdog in 12 of Giolito's starts this season, and they went 7-5 in those matchups.

Blue Jays vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (57%)

Blue Jays vs Red Sox Moneyline

• Toronto is the favorite, -166 on the moneyline, while Boston is a +140 underdog on the road.

Blue Jays vs Red Sox Spread

• The Red Sox are at +1.5 on the runline against the Blue Jays. The Red Sox are -156 to cover the spread, and the Blue Jays are +130.

Blue Jays vs Red Sox Over/Under

• The Blue Jays-Red Sox contest on Sept. 23 has been given an over/under of 8 runs. The over is set at -105 and the under at -115.

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Blue Jays vs Red Sox Betting Trends

• The Blue Jays have won in 45, or 57.7%, of the 78 contests they have been named as odds-on favorites in this year.
• Toronto has a record of 18-5 when favored by -166 or more this year.
• The Blue Jays and their opponents have hit the over in 84 of their 155 games with a total set by oddsmakers this season.
• The Blue Jays have posted a record of 88-67-0 against the spread this season.
• The Red Sox have been the underdog on the moneyline 50 total times this season. They've finished 23-27 in those games.
• When playing as a moneyline underdog with odds of +140 or longer, Boston has gone 6-5 (54.5%).
• The Red Sox have had an over/under set by oddsmakers 155 times, and have combined with opponents to go over the total in 73 of those games (73-75-7).
• The Red Sox have an 82-73-0 record against the spread this season (covering 52.9% of the time).

Blue Jays Player Leaders

• Vladimir Guerrero Jr. is batting .299 with 34 doubles, 23 home runs and 80 walks. He has an on-base percentage of .389 while slugging .481.
• Among qualifying hitters in baseball, his batting average ranks eighth, his on-base percentage ranks sixth, and he is 30th in slugging.
• Guerrero will look for his third straight game with a hit in this contest. During his last five outings he is batting .200 with a double and two RBIs.
• George Springer has 145 hits and an OBP of .395, both of which lead the Blue Jays this season. He's batting .305 and slugging .552.
• He ranks fourth in batting average, third in on-base percentage and fifth in slugging among qualified hitters.
• Springer has picked up at least one hit in three games in a row. During his last five outings he is hitting .316 with two doubles, a home run, two walks and two RBIs.
• Ernie Clement has 146 hits this season and has a slash line of .279/.315/.401.
• Alejandro Kirk has 12 home runs, 69 RBI and a batting average of .285 this season.

Red Sox Player Leaders

• Jarren Duran has racked up an on-base percentage of .336, a slugging percentage of .449, and has 156 hits, all club-bests for the Red Sox (while batting .260).
• Including all the qualifying hitters in the majors, his batting average ranks 62nd, his on-base percentage is 55th, and he is 56th in slugging.
• Duran takes a three-game hitting streak into this game. During his last five outings he is batting .318 with a home run, three walks and two RBIs.
• Trevor Story's .439 slugging percentage leads his team. He has a batting average of .264 with an on-base percentage of .311.
• He is currently 55th in batting average, 104th in on-base percentage and 63rd in slugging percentage among all qualifying hitters.
• Alex Bregman is batting .278 with 27 doubles, 18 home runs and 49 walks.
• Ceddanne Rafaela is hitting .244 with 31 doubles, three triples, 16 home runs and 26 walks.

Blue Jays vs Red Sox Head to Head

• 6/29/2025: 5-3 TOR (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/28/2025: 15-1 BOS (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/27/2025: 9-0 TOR (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/1/2025: 4-2 TOR (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2025: 7-6 TOR (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/29/2025: 10-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/10/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/9/2025: 2-1 TOR (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/8/2025: 6-1 TOR (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/7/2025: 6-2 TOR (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)

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