Bills vs Patriots Prediction, Odds, Picks, Best Bets for NFL Week 5 Sunday Night Football

The NFL's Sunday slate includes the Buffalo Bills taking on the New England Patriots.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

Bills vs Patriots Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (77.5%)

Bills vs Patriots Point Spread

The Bills are 8.5-point favorites against the Patriots. The Bills are -104 to cover the spread, while the Patriots are -118 to cover as an 8.5-point underdog.

Bills vs Patriots Over/Under

The Bills-Patriots game on Oct. 5 has been given an over/under of 50.5 points. The over is -105 and the under is -115.

Bills vs Patriots Moneyline

The Bills vs Patriots moneyline has the Bills as a -420 favorite, while the Patriots are a +330 underdog on the road.

Bills vs Patriots Betting Trends

• Buffalo has won twice against the spread this season.
• The Bills have no wins ATS (0-2) as an 8.5-point favorite or greater this season.
• Out of four Bills games so far this season, three have hit the over.
• The Patriots have two wins against the spread this season.
• Two Patriots games (out of four) have gone over the point total this season.

Check out even more in-depth Bills vs. Patriots analysis on FanDuel Research.

Bills vs Patriots Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-420) | NE: (+330)
• Spread: BUF: -8.5 (-104) | NE: +8.5 (-118)
• Total: 50.5 -- Over: (-105) | Under: (-115)

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