Bills vs Patriots Prediction, Odds, Picks, Best Bets for NFL Week 5 Sunday Night Football

The Buffalo Bills will take on the New England Patriots in NFL action on Sunday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info about today's NFL betting odds.

Bills vs Patriots Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (77.5%)

Bills vs Patriots Point Spread

The Bills are 8.5-point favorites against the Patriots. The Bills are -104 to cover the spread, while the Patriots are -118 to cover as an 8.5-point underdog.

Bills vs Patriots Over/Under

A total of 49.5 points has been set for the Bills-Patriots matchup on Oct. 5, with the over available at -112 and the under at -108.

Bills vs Patriots Moneyline

The Bills vs Patriots moneyline has the Bills as a -461 favorite, while the Patriots are a +360 underdog on the road.

Bills vs Patriots Betting Trends

• Buffalo has two wins against the spread this season.
• The Bills are winless ATS (0-2) when playing as at least 8.5-point favorites this year.
• There have been three Bills games (out of four) that went over the total this year.
• The Patriots have posted two wins against the spread this season.
• Two of the Patriots' four games in 2025 have gone over the point total.

Check out even more in-depth Bills vs. Patriots analysis on FanDuel Research.

Bills vs Patriots Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-461) | NE: (+360)
• Spread: BUF: -8.5 (-104) | NE: +8.5 (-118)
• Total: 49.5 -- Over: (-112) | Under: (-108)

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