Athletics vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 9:12 p.m.

The Athletics will face the Houston Astros in MLB action on Tuesday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Athletics vs Astros Game Info

• Athletics (73-83) vs. Houston Astros (84-72)
• Date: Tuesday, September 23, 2025
• Time: 10:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Athletics vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: OAK: (-112) | HOU: (-104)
• Spread: OAK: +1.5 (-178) | HOU: -1.5 (+146)
• Total: 10 -- Over: (-108) | Under: (-112)

Athletics vs Astros Probable Starting Pitchers

Probable Pitchers: Jeffrey Springs (Athletics) - 10-11, 4.17 ERA vs Cristian Javier (Astros) - 2-3, 4.45 ERA

The probable starters are Jeffrey Springs (10-11) for the Athletics and Cristian Javier (2-3) for the Astros. Springs and his team have a record of 15-14-0 against the spread when he starts. Springs' team has a record of 2-7 this season when he starts and they are the favorite on the moneyline. When Javier starts, the Astros are 3-4-0 against the spread. The Astros are 3-2 in Javier's five starts this season that they were the underdog on the moneyline.

Athletics vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (50.4%)

Athletics vs Astros Moneyline

• The Athletics vs Astros moneyline has the Athletics as a -112 favorite, while the Astros are a -104 underdog on the road.

Athletics vs Astros Spread

• The Athletics are hosting the Astros and are 1.5 on the runline and -178 to cover, while Houston is +146 to cover the spread.

Athletics vs Astros Over/Under

• A combined run total of 10 has been set for Athletics-Astros on Sept. 23, with the over at -108 and the under at -112.

Bet on Athletics vs. Houston Astros on FanDuel today!

Athletics vs Astros Betting Trends

• The Athletics have come away with 17 wins in the 35 contests they have been listed as the favorites in this season.
• This year, the Athletics have won 14 of 29 games when listed as at least -112 or better on the moneyline.
• The Athletics and their opponents have hit the over in 75 of their 155 games with a total this season.
• The Athletics have an against the spread record of 82-73-0 in 155 games with a line this season.
• The Astros have won 57.1% of the games this season they were the moneyline underdog (32-24).
• In games they have played as a moneyline underdog with odds of -104 or longer, the Astros have gone 29-22 (56.9%).
• The Astros have combined with their opponents to go over the total 71 times this season for a 71-80-4 record against the over/under.
• The Astros are 77-78-0 ATS this season.

Athletics Player Leaders

• Brent Rooker has an OPS of .824, fueled by an OBP of .336 and a team-best slugging percentage of .488 this season. He has a .265 batting average.
• Among qualified hitters in the majors, he is 51st in batting average, 55th in on-base percentage, and 21st in slugging.
• Tyler Soderstrom has 31 doubles, a triple, 24 home runs and 53 walks. He's batting .277 and slugging .470 with an on-base percentage of .347.
• Among all qualified, he ranks 29th in batting average, 43rd in on-base percentage and 39th in slugging percentage.
• Nick Kurtz is batting .291 with a .613 slugging percentage and 81 RBI this year.
• Jacob Wilson leads Sacramento with an OBP of .357 this season while batting .315 with 25 walks and 60 runs scored.

Astros Player Leaders

• Jose Altuve has accumulated a team-best .444 slugging percentage. He's batting .265 with an on-base percentage of .327.
• Including all qualified hitters, he is 51st in batting average, while his on-base percentage ranks 76th and he is 61st in slugging.
• Jeremy Pena's 150 hits and .363 OBP are both team-highs. He has a batting average of .304 while slugging .477.
• His batting average ranks sixth among all qualified players, his on-base percentage ranks 16th, and he is 33rd in slugging.
• Yainer Diaz is batting .256 with 23 doubles, a triple, 19 home runs and 20 walks.
• Carlos Correa is batting .273 with 27 doubles, 13 home runs and 41 walks.

Athletics vs Astros Head to Head

• 7/27/2025: 7-1 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/26/2025: 5-1 OAK (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/25/2025: 15-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/24/2025: 5-2 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/19/2025: 6-4 OAK (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/18/2025: 11-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/17/2025: 13-3 HOU (Favorite: Astros, Spread: -1.5, Total: 11, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/16/2025: 3-1 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2025: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2025: 11-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -240, Underdog Moneyline: +198)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!