Appalachian State vs Southern Miss Prediction, Odds, Picks, Best Bets for Week 3 2025

College football's Saturday slate includes the Appalachian State Mountaineers taking on the Southern Miss Golden Eagles.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding today's NCAA football betting odds.

Appalachian State vs Southern Miss Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Appalachian State: (-172) | Southern Miss: (+142)
• Spread: Appalachian State: -3.5 (-106) | Southern Miss: +3.5 (-114)
• Total: 56.5 -- Over: (-110) | Under: (-110)

Appalachian State vs Southern Miss Betting Trends

• Appalachian State hasn won once against the spread this season.
• As a 3.5-point or greater favorite, Appalachian State has one win ATS (1-1) this season.
• Southern Miss has one win against the spread this season.
• Southern Miss has no wins ATS (0-1) as a 3.5-point underdog or more this season.
• One of Southern Miss' two games has hit the over.

Appalachian State vs Southern Miss Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Mountaineers win (70.9%)

Appalachian State vs Southern Miss Point Spread

Appalachian State is a 3.5-point favorite against Southern Miss. Appalachian State is -106 to cover the spread, and Southern Miss is -114.

Appalachian State vs Southern Miss Over/Under

Appalachian State versus Southern Miss on Sept. 13 has an over/under of 56.5 points, with the over -110 and the under -110.

Appalachian State vs Southern Miss Moneyline

The moneyline numbers for Appalachian State vs. Southern Miss reveal Appalachian State as the favorite (-172) and Southern Miss as the underdog (+142).

Appalachian State vs. Southern Miss Points Insights

Appalachian State vs. Southern Miss Game Info

• Game day: Saturday, September 13, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN+
• Location: Hattiesburg, Mississippi
• Stadium: M.M. Roberts Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Appalachian State vs. Southern Miss analysis on FanDuel Research.