Appalachian State vs Southern Miss Prediction, Odds, Picks, Best Bets for Week 3 2025

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Saturday's slate in college football includes a matchup between the Appalachian State Mountaineers and the Southern Miss Golden Eagles.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Appalachian State vs Southern Miss Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Appalachian State: (-144) | Southern Miss: (+118)
Spread: Appalachian State: -2.5 (-120) | Southern Miss: +2.5 (-102)
Total: 56.5 -- Over: (-110) | Under: (-110)

Appalachian State has one win against the spread this season.
Appalachian State has won once ATS (1-1) as a 2.5-point or higher favorite this season.
Southern Miss has but one win versus the spread this year.
Southern Miss doesn't have a win ATS (0-1) as a 2.5-point underdog or more this season.
One of Southern Miss' two games has gone over the point total.

All college football win probability predictions and picks are according to numberFire.
Prediction: Mountaineers win (68.1%)

Appalachian State is favored by 2.5 points (-120 to cover) in this matchup. Southern Miss, the underdog, is -102.

An over/under of 56.5 has been set for Appalachian State-Southern Miss on Sept. 13, with the over being -110 and the under -110.

Looking at the moneyline for Appalachian State-Southern Miss, Appalachian State is the favorite at -144, and Southern Miss is +118.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Appalachian State	27.0	77	12.0	38	52.0	2
Southern Miss	27.5	73	27.0	95	56.5	2

Check out even more in-depth Appalachian State vs. Southern Miss analysis on FanDuel Research.

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