Yankees vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 7:12 p.m.

The New York Yankees versus the Minnesota Twins is on the MLB schedule for Tuesday.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Twins Game Info

• New York Yankees (83-67) vs. Minnesota Twins (66-84)
• Date: Tuesday, September 16, 2025
• Time: 7:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and YES

Yankees vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-168) | MIN: (+142)
• Spread: NYY: -1.5 (-102) | MIN: +1.5 (-118)
• Total: 9 -- Over: (-110) | Under: (-110)

Yankees vs Twins Probable Starting Pitchers

Probable Pitchers: Cam Schlittler (Yankees) - 3-3, 3.05 ERA vs Zebby Matthews (Twins) - 4-5, 5.06 ERA

The Yankees will look to Cam Schlittler (3-3) versus the Twins and Zebby Matthews (4-5). Schlittler and his team have a record of 5-5-0 against the spread when he starts. Schlittler's team has won 57.1% of his starts when they are favored on the moneyline (4-3). The Twins have a 5-9-0 ATS record in Matthews' 14 starts with a set spread. The Twins have been the moneyline underdog in five of Matthews' starts this season, and they went 3-2 in those games.

Yankees vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (57.2%)

Yankees vs Twins Moneyline

• New York is a -168 favorite on the moneyline, while Minnesota is a +142 underdog at home.

Yankees vs Twins Spread

• The Yankees are 1.5-run road favorites on the runline against the Twins. The Yankees are -102 to cover, and the Twins are -118.

Yankees vs Twins Over/Under

• The over/under for Yankees-Twins on Sept. 16 is 9. The over is -110, and the under is -110.

Bet on New York Yankees vs. Minnesota Twins on FanDuel today!

Yankees vs Twins Betting Trends

• The Yankees have won in 74, or 58.7%, of the 126 contests they have been named as odds-on favorites in this year.
• This year New York has won 35 of 52 games when listed as at least -168 on the moneyline.
• The Yankees and their opponents have gone over in 72 of their 148 games with a total set by sportsbooks this season.
• The Yankees are 68-80-0 against the spread in their 148 games with a line set by sportsbooks this season.
• The Twins have won 39.3% of the games this season they were the underdog on the moneyline (22-34).
• Minnesota has gone 5-8 in games it has played as a moneyline underdog with odds of +142 or longer (38.5%).
• The Twins have had an over/under set by bookmakers 145 times, and have combined with opponents to go over the total in 69 of those games (69-69-7).
• The Twins have a 70-75-0 record against the spread this season.

Yankees Player Leaders

• Aaron Judge has 163 hits and an OBP of .449 to go with a slugging percentage of .677. All three of those stats are best among New York hitters this season. He has a .325 batting average, as well.
• Among all qualifying hitters in the majors, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Cody Bellinger is batting .274 with 25 doubles, five triples, 28 home runs and 48 walks. He's slugging .493 with an on-base percentage of .329.
• He is 33rd in batting average, 72nd in on-base percentage and 23rd in slugging in the major leagues.
• Trent Grisham has collected 107 base hits, an OBP of .347 and a slugging percentage of .459 this season.
• Jazz Chisholm is batting .242 with a .335 OBP and 75 RBI for New York this season.

Twins Player Leaders

• Byron Buxton has accumulated 120 hits with a .334 on-base percentage and a .553 slugging percentage, all club-highs for the Twins. He's batting .271.
• Including all qualified hitters, he ranks 36th in batting average, while his on-base percentage ranks 59th and he is fifth in slugging.
• Trevor Larnach's .404 slugging percentage leads his team. He has a batting average of .253 with an on-base percentage of .326.
• He is currently 87th in batting average, 80th in on-base percentage and 93rd in slugging percentage among all qualifying hitters.
• Brooks Lee is batting .238 with 15 doubles, a triple, 15 home runs and 30 walks.
• Kody Clemens is hitting .216 with 11 doubles, three triples, 19 home runs and 26 walks.

Yankees vs Twins Head to Head

• 9/15/2025: 7-0 MIN (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 8/12/2025: 9-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/11/2025: 6-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/6/2024: 8-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/5/2024: 9-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 6/4/2024: 5-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/16/2024: 5-0 NYY (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/15/2024: 4-0 NYY (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/14/2024: 5-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2023: 12-6 NYY (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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