Brewers vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 7:11 p.m.

Tuesday's slate in the MLB includes a matchup between the Milwaukee Brewers and the Los Angeles Angels.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Brewers vs Angels Game Info

• Milwaukee Brewers (91-59) vs. Los Angeles Angels (69-81)
• Date: Tuesday, September 16, 2025
• Time: 7:40 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: FDSWI

Brewers vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-270) | LAA: (+220)
• Spread: MIL: -1.5 (-126) | LAA: +1.5 (+105)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Brewers vs Angels Probable Starting Pitchers

Probable Pitchers: Freddy Peralta (Brewers) - 16-6, 2.69 ERA vs Caden Dana (Angels) - 0-1, 6.32 ERA

This contest's pitching matchup is set, as the Brewers will send Freddy Peralta (16-6) to the mound, while Caden Dana (0-1) will get the nod for the Angels. When Peralta starts, his team is 17-13-0 against the spread this season. Peralta's team has been victorious in 63.2% of the games he's started as the moneyline favorite with a record of 12-7. Dana has started two games with set spreads, and the Angels went 1-1-0. The Angels were named the moneyline underdog for one Dana start this season -- they won.

Brewers vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (74.2%)

Brewers vs Angels Moneyline

• Los Angeles is the underdog, +220 on the moneyline, while Milwaukee is a -270 favorite at home.

Brewers vs Angels Spread

• The Brewers are hosting the Angels and are favored by 1.5 runs (-126 to cover) on the runline. Los Angeles is +105 to cover.

Brewers vs Angels Over/Under

• The over/under for the Brewers versus Angels contest on Sept. 16 has been set at 8.5, with -105 odds on the over and -115 odds on the under.

Bet on Milwaukee Brewers vs. Los Angeles Angels on FanDuel today!

Brewers vs Angels Betting Trends

• The Brewers have won in 55, or 64.7%, of the 85 contests they have been named as odds-on favorites in this year.
• Milwaukee has not lost in three games this year when favored by -270 or better on the moneyline.
• The Brewers and their opponents have gone over the total this season in 74 of their 147 opportunities.
• The Brewers are 82-65-0 against the spread in their 147 games with a line set by sportsbooks this season.
• The Angels have a 50-61 record in games they were the underdog on the moneyline (winning 45% of those games).
• Los Angeles has a 1-2 record (winning only 33.3% of its games) when it has played as a moneyline underdog of +220 or longer.
• The Angels have combined with opponents to go over the total 79 times this season for a 79-64-5 record against the over/under.
• The Angels have an 80-68-0 record ATS this season (covering 54.1% of the time).

Brewers Player Leaders

• Brice Turang has an OPS of .792, fueled by an OBP of .353 and a team-best slugging percentage of .439 this season. He has a .286 batting average.
• Among qualifying hitters in the majors, his batting average ranks 16th, his on-base percentage ranks 34th, and he is 66th in slugging.
• William Contreras has 26 doubles, 17 home runs and 79 walks. He's batting .263 and slugging .406 with an on-base percentage of .357.
• He is 54th in batting average, 23rd in on-base percentage and 91st in slugging among qualified hitters.
• Christian Yelich has collected 139 base hits, an OBP of .343 and a slugging percentage of .458 this season.
• Jackson Chourio has 139 hits, which is tops among Milwaukee hitters this season, while batting .280 with 57 extra-base hits.

Angels Player Leaders

• Taylor Ward is batting .223 with 31 doubles, two triples, 31 home runs and 72 walks. He's slugging .459 with an on-base percentage of .313.
• He is 140th in batting average, 106th in on-base percentage and 48th in slugging percentage among all qualified hitters in MLB.
• Jo Adell paces his team with 116 hits. He has a batting average of .241 while slugging .505 with an on-base percentage of .300.
• His batting average ranks 111th among all qualified players, his on-base percentage is 123rd, and he is 15th in slugging.
• Zach Neto has put up a team-best .474 slugging percentage.
• Mike Trout paces his team with a .361 on-base percentage.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!